Stem cells, cancer, and cancer stem cells - PowerPoint PPT Presentation


PPT – Stem cells, cancer, and cancer stem cells PowerPoint presentation | free to download - id: 44104f-MjE4Z


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation

Stem cells, cancer, and cancer stem cells


Stem cells, cancer, and cancer stem cells 113 lab seminar 1 Stem cells? Stem cells are defined as cells that have the ability to ... – PowerPoint PPT presentation

Number of Views:532
Avg rating:3.0/5.0
Slides: 16
Provided by: primateO1
Learn more at:
Tags: cancer | cells | stem


Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: Stem cells, cancer, and cancer stem cells

Stem cells, cancer, andcancer stem cells
  • 113? lab seminar
  • ?? 1? ???

Stem cells?
  • Stem cells are defined as cells that have the
  • ability to perpetuate themselves through
  • self-renewal and to generate mature cells of
  • a particular tissue through differentiation. In
  • most tissues, stem cells are rare. As a result,
  • stem cells must be identified prospectively
  • and purified carefully

Focus on three aspects of the relationship
between stem cells and tumour cells
  • 1.The similarities in the mechanisms that
    regulate self-renewal of normal stem cells and
    cancer cells
  • 2.The possibility that tumour cells might arise
    from normal stem cells
  • 3.The notion tumours might contain cancer stem

Self-renewal of haematopoietic stem cell
  • ?Three different populations
  • 1.Long-term self-renewing HSCs,
  • 2.Short-term self-renewing HSCs,
  • 3.Multipotent progenitors without detectable
    self-renewal potential

(No Transcript)
Stem self-renewal Versus Oncogenesis
  • ? Many pathways are associated with cancer may
    also regulated normal stem cell development
  • 1.Bcl-2
  • 2.Bmi1
  • 3.Notch
  • 4.Sonic hedgehog(Shh)
  • 5.Wnt signalling

(No Transcript)
Self-renewal and Leukaemogenesis
  • If stem cell self-renewal lead to
  • tumorgenesis then are stem cells themselves
  • the target of transformation in certain types
  • of cancer?
  • 1.Stem cells have the machinery for self-renewal
    already activated
  • 2.By self-renewing, stem cells often persist for
    long period of time

Stem cells targets of Mutation
  • Proposed Cell-Surface Markers of the
  • Undifferentiated HSCs  

Mouse Human
CD34low- CD 34
SCA-1 CD59
Thy1low Thy1
CD38 CD38low-
C-kit C-kit -low
lin  lin
Progenitor cells as targets of transformation
Cancer stem cells and aberrant organogenesis
  • Both normal stem cells and tumorgenic cells
  • give rise to phenotypically heterogenous
  • cells that exhibit various degrees of
  • differentiation
  • Thus, tumorgenic cells can be thought of
  • analogous to what normal stem cells do

Evidence for cancer stem cell
The implications of solid cancer stem cells
Summary Perspective
  • 1.Self renewal is the hallmark property of stem
    cells in normal and neoplastic tissue
  • 2. In the haematipoietic system, long-term self
    renewal is limited to rare long-term HSCs and
    some lymphocyte
  • 3.Cells that continue to devide over long periods
    of time are much more likely to accumulate
  • 4.Normal tissues contain self-renewing stem cells

  • 5.Distinct signalling pathways control stem cell
    renewal in different tissues
  • 6.Understanding the signalling pathways..
  • 7.Most tumors there may exist cancer stem cells
    that can self-renew indefinitely, in contrast
  • 8.Necessary to identify and kill the cancer cell