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SICKLE CELL DISEASE

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SICKLE CELL DISEASE-Monica Sickle Cell is inherited, and it affects the shape of red blood cells. Genetic: Caused by a Hemoglobin S (sickle) molecule. – PowerPoint PPT presentation

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Title: SICKLE CELL DISEASE


1
SICKLE CELL DISEASE
  • -Monica

2
Sickle Cell is inherited, and it affects the
shape of red blood cells.
  • Genetic Caused by a Hemoglobin S (sickle)
    molecule.
  • Hemoglobin F (fetal) What we start with.
  • Hemoglobin A (adult) What we end up with.
  • (Some people never replace all of the HGB F)

3
HGB S is only 1 odd protein out of 300, but it
causes severe defects.
  • Affected RBCs undergo polymerization and lose
    most of the water in the cell.
  • -They become crescent shaped, sticky, and
    inflexible.
  • -Hard to pass through capillaries.

4
Sickled cells
5
Lifespan 10-20 days
  • -Compared to our 90-120 days
  • -Destroyed by the spleen.
  • -Sometimes the body cant make new RBCs fast
    enough.
  • -Resulting in anemia.

6
Inheritance
  • -Most common in African Americans.
  • -2 recessive traits the disease.
  • -One parents with the disease and one parent with
    the recessive trait have a 1 in 2 chance of
    having an affected child.

7
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8
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9
Signs and Symptoms
  • -Anemia, infections, and pain.
  • -Acute Chest Syndrome
  • -Hand-Foot Syndrome
  • -Splenic Crises
  • -Generalized body pain
  • -Possible stroke, or MI

10
Treatment
  • -Daily Penicillin
  • -Bone marrow transplants
  • -meds to prevent water from leaving the cells
  • (Clotrimazole)

11
New Experimental Treatment
  • Gene Replacement

12
Prehospital Treatment
  • Mainly treatment of symptoms.
  • -Pain management
  • -Fluid replacement

13
Sources
  • -Nelson D.L. (2005). Lehninger Principles of
    Biochemistry4th ed. New York,NY WH Freeman and
    Co.
  • -Sickle Cell Disease Association of America, Inc.
    2005. SCDAA Homepage. http//sicklecelldisease.org
  • -Sickle cell Society lthttp//sicklecellsociety.org
    gt
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