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INTRAVENOUS INFUSION

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ONE COMPARTMENT MODEL WITH IV INFUSION This can be obtained by high degree of precision by infusing drugs i.v. via a drip or pump in hospitals PK of Drug Given by ... – PowerPoint PPT presentation

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Title: INTRAVENOUS INFUSION


1
CHAPTER 4
  • INTRAVENOUS INFUSION

2
ONE COMPARTMENT MODEL WITH IV INFUSION
  • This can be obtained by high degree of precision
    by infusing drugs i.v. via a drip or pump in
    hospitals

3
PK of Drug Given by IV Infusion
  • Zero-order Input (infusion rate, R)
  • First-order Output (elimination)

4
Integrated equation
  • Zero-order Input (infusion rate, R)
  • First-order Output (elimination)
  • By integration,

5
Stopping the Infusion
  • Stopping the infusion before reaching steady
    state

Infusion stops
6
Stopping the Infusion
  • Equations

7
Steady State Concentration
  • IV Infusion until reaching Css

8
Steady State Concentration (Css)
  • Theoretical SS is only reached after an infinite
    infusion time
  • Rate of elimination kel Cp

9
Steady State Concentration (Css)
  • Rate of Infusion Rate of Elimination
  • ? The infusion rate (R) is fixed while the
  • rate of elimination steadily increases
  • ? The time to reach SS is directly
  • proportional to the half-life
  • ? After one half-life, the Cp is 50 of the
    CSS, after 2 half-lives, Cp is 75 of the Css
    .

10
Steady State Concentration (Css)
  • In clinical practice, the SS is considered to be
    reached after five half-lives

11
Increasing the Infusion Rate
  • If a drug is given at a more rapid infusion rate,
    a higher SS drug concentration is obtained but
    the time to reach SS is the same.

12
Loading Dose plus IV Infusion
  • DL with IV infusion at the same time

Loading dose
IV infusion
DL IV infusion
13
Loading Dose plus IV Infusion
  • DL is used to reach SS rapidly

14
Reaching SS Immediately
  • Let , DL CssVd But, CssVd R / kel
  • Therefore, if a DL R / kel is given SS will be
    reached immediately

but
15
Reaching SS Immediately
  • IV DL equal to R /kel is given, followed by IV
    infusion at a rate R

16
DL IV Infusion
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