# INTRAVENOUS INFUSION - PowerPoint PPT Presentation

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## INTRAVENOUS INFUSION

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### ONE COMPARTMENT MODEL WITH IV INFUSION This can be obtained by high degree of precision by infusing drugs i.v. via a drip or pump in hospitals PK of Drug Given by ... – PowerPoint PPT presentation

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Title: INTRAVENOUS INFUSION

1
CHAPTER 4
• INTRAVENOUS INFUSION

2
ONE COMPARTMENT MODEL WITH IV INFUSION
• This can be obtained by high degree of precision
by infusing drugs i.v. via a drip or pump in
hospitals

3
PK of Drug Given by IV Infusion
• Zero-order Input (infusion rate, R)
• First-order Output (elimination)

4
Integrated equation
• Zero-order Input (infusion rate, R)
• First-order Output (elimination)
• By integration,

5
Stopping the Infusion
• Stopping the infusion before reaching steady
state

Infusion stops
6
Stopping the Infusion
• Equations

7
• IV Infusion until reaching Css

8
• Theoretical SS is only reached after an infinite
infusion time
• Rate of elimination kel Cp

9
• Rate of Infusion Rate of Elimination
• ? The infusion rate (R) is fixed while the
• rate of elimination steadily increases
• ? The time to reach SS is directly
• proportional to the half-life
• ? After one half-life, the Cp is 50 of the
CSS, after 2 half-lives, Cp is 75 of the Css
.

10
• In clinical practice, the SS is considered to be
reached after five half-lives

11
Increasing the Infusion Rate
• If a drug is given at a more rapid infusion rate,
a higher SS drug concentration is obtained but
the time to reach SS is the same.

12
• DL with IV infusion at the same time

IV infusion
DL IV infusion
13
• DL is used to reach SS rapidly

14
Reaching SS Immediately
• Let , DL CssVd But, CssVd R / kel
• Therefore, if a DL R / kel is given SS will be
reached immediately

but
15
Reaching SS Immediately
• IV DL equal to R /kel is given, followed by IV
infusion at a rate R

16
DL IV Infusion