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Inflammation p.2

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Inflammation p.2 SYLLABUS: RBP(Robbins Basic Pathology) Chapter: Acute and Chronic Inflammation PBD (Pathologic Basis of Disease) Infectious Diseases – PowerPoint PPT presentation

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Title: Inflammation p.2


1
Inflammation p.2
SYLLABUS RBP(Robbins Basic Pathology)
Chapter Acute and Chronic Inflammation PBD
(Pathologic Basis of Disease) Infectious
Diseases
2
Inflammation p.2
  • 109 Miliary tuberculosis
  • 111 Tuberculous cavity of the lung
  • 120 Actinomycosis
  • 151 Sarcoidosis
  • Enterobiasis (appendix)
  • Trichinosis (muscle)
  • Nch8025/S Cerebral toxoplasmosis
  • 122 Cysticercosis (CNS)

3
Miliary tuberculosis (lung)
  • millet seed- size (up to 2mm) TB granulomas
  • giant Langhans cells
  • epithelioid cells
  • lymphocytes
  • - caseous necrosis

4
Miliary tuberculosis
5
Miliary tuberculosis
6
Miliary tuberculosis
7
Tuberculous cavity of the lung
the wall of a cavity internal layer - caseous
necrosis middle layer - components of TB
granulomas outer layer -granulation
tissue -fibrous tissue
8
Tuberculous cavity of the lung
please note the micro-slide contains a fragment
of a wall of a big TB cavity, dont search for
small cavities inside that specimen
9
Tuberculous cavity of the lung
10
Tuberculous cavity of the lung
11
Actinomycosis
Actinomyces colonies surrounded by the purulent
inflammtory infiltration
12
Actinomycosis
13
Actinomycosis
14
Sarcoidosis
noncaseating granulomas composed of -
epithelioid cells, - Langhans cells - lymphocytes
15
Sarcoidosis
16
Sarcoidosis
17
Enterobiasis (appendix)
  • Tissue
  • normal mucosa
  • or eosinophilic reaction
  • or acute appendicitis
  • Worms
  • - distinctive lateral alae (thorns in cross
    section) - sections may show eggs within worms
    (eggs may also be seen alone)

18
Enterobiasis (appendix)
19
Enterobiasis (appendix)
20
Trichinosis (muscle)
  • Worms
  • - encysted coiled roundworms
  • Tissue
  • muscle cells with inflammation including
    eosinophils and macrophages
  • fiber necrosis
  • - larval death triggers eosinophilic
    granulomatous inflammation leading to
    calcification
  • or
  • - a chronic, inactive stage where encysted
    organisms are found in the absence of any
    cellular response.

21
Trichinosis (muscle)
22
Trichinosis (muscle)
23
Cerebral toxoplasmosis
  • central foci of necrosis and petechial
    hemorrhages surrounded by inflammatory cells,
    mainly macrophages
  • organisms (Toxoplasma gondii) at the periphery of
    the necrotic foci
  • marked proliferation of intima in blood vessels
    in the vicinity of the necrosis

24
Cerebral toxoplasmosis
25
Cerebral toxoplasmosis
26
Cerebral toxoplasmosis
27
Cysticercosis (CNS)
  • Worm
  • fluid-filled cyst with eosinophilic laminated
    wall lined by monolayer of rare nuclei
  • older lesions fibrotic and calcified
  • Tissue
  • little inflammation unless ruptured
  • (.ppt demonstration only, no slides during the
    microscopy lab)

28
Cysticercosis (CNS)
29
Cysticercosis (CNS)
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