Grand Challenges for Nanomedicine - PowerPoint PPT Presentation

Loading...

PPT – Grand Challenges for Nanomedicine PowerPoint presentation | free to download - id: 3e8028-YWVjY



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

Grand Challenges for Nanomedicine

Description:

Grand Challenges for Nanomedicine and Nanobiology Workshop Houston, Texas August 27th, 2007 Personal Thoughts Targeted Delivery (Timing) EPR Tumor vasculature ... – PowerPoint PPT presentation

Number of Views:47
Avg rating:3.0/5.0
Slides: 10
Provided by: ncmiBcmE
Learn more at: http://ncmi.bcm.edu
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: Grand Challenges for Nanomedicine


1
  • Grand Challenges for Nanomedicine
  • and Nanobiology Workshop
  • Houston, Texas
  • August 27th, 2007

2
Personal Thoughts
  • Targeted Delivery (Timing)
  • EPR
  • Tumor vasculature
  • Potential for clinical impact versus clinical
    translation
  • Diagnostics and Nanotechnology?
  • Training and Team Science
  • Multi-PI R01s
  • NIH Pathway to Independence Award (K99/R00)
  • Mentored Research Scientist Development Award
    (K01)
  • Mentored Clinical Scientist Development Award
    (K08)
  • Clinical Oncology Training Grants (K12)

3
Upcoming Sessions
  • Nano Tutorial Sessions Oct 16th, 2007
  • Tutorial Session 1 Cells, Tissues, and Organs
    Basic Principles of Functional Histology and
    Pathology
  • Tutorial Session 2 Basic Cancer Biology
  • Tutorial Session 3 Animal Models
  • Tutorial Session 4 Biodistribution of
    Nanoparticles
  • Tutorial Session 5 Materials Science/Nanotechnolo
    gy
  • Clinical Pathway
  • Clinical trial grants and contracts
  • FDA
  • Nanotechnology Characterization Lab
  • ASCB Special Session Dec 1st, 2007

4
Upcoming NIH Funding Opportunities
  • Nanoscience and Nanotechnology in Biology and
    Medicine (R01R21), Oct. 22nd, 2007
  • Biology of Breast Pre-Malignancies (R01), Nov.
    17th, 2007
  • RFA-CA-07-047
  • insufficient understanding of normal and
    pre-cancer biology

5
Upcoming NCI Funding Opportunities
  • SBIR Solicitation (PHS-2008-1), Nov. 5th, 2007
  • Topic 241 Multifunctional Therapeutics Based on
    Nanotechnology
  • Topic 252 Nanotechnology Imaging and Sensing
    Platforms for Improved Diagnosis of Cancer
  • Multidisciplinary Development and Training in
    Cancer Nanotechnology Award (F32/F33), TBA
  • Innovative Molecular Analysis Technologies IMAT
    (R21/R33), Sept. 27th, 2007
  • Innovative Technologies for the Molecular
    Analysis of Cancer RFA-CA-07-033
  • Application of Emerging Technologies for Cancer
    Research RFA-CA-07-035

nano.cancer.gov
6
Nanotechnology Characterization Lab (NCL)Role
and Updates
  • The NCL developed and standardized analytical
    cascade that tests the pre-clinical toxicology,
    pharmacology, and efficacy of nanoparticles and
    devices.
  • Next submission date (9/1/2007 and 12/1/2007)

7
NCL in vivo Characterization Assays
Plasma Profile
  • Initial disposition study
  • Tissue Distribution
  • Clearance
  • Half-life
  • Systemic exposure (plasma AUC)  
  • Immunotoxicity
  • 28 day screen
  • Immunogenicity (repeat-dose tox study)   
  • Dose -Range Finding Toxicity
  • Blood Chemistry
  • Hematology
  • Histopathology
  • Gross Pathology
  • GLP Studies
  • PK/ADME
  • Expanded Single Dose Acute Tox

Organ Weights Main Study
Hematology Interim Study
8
Current NCL Collaborators
9
Onsite Program Contacts
  • Larry Nagahara, Ph.D.Nanotechnology Projects
    Manager
  • Email  nagaharl_at_mail.nih.gov
  • Jerry Lee, Ph.D.
  • Tech. Dev. Program Officer
  • Email leejerry_at_mail.nih.gov
About PowerShow.com