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Escherichia coli O157:H7

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Escherichia coli O157:H7 Javier Chavez Cathy Miller Meridith Phillips Patty Roth Introduction What is E. coli? Vocabulary How is it spread? What are the symptoms? – PowerPoint PPT presentation

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Title: Escherichia coli O157:H7


1
Escherichia coli O157H7
  • Javier Chavez
  • Cathy Miller
  • Meridith Phillips
  • Patty Roth

2
Introduction
  • What is E. coli?
  • Vocabulary
  • How is it spread?
  • What are the symptoms?
  • Who does it affect?
  • What is the treatment?

3
What is E. coli?
  • Esherichia coli O157H7 is one of hundreds of
    strains of the bacterium Eshcherichia coli.
  • Most strains live in the intestines of healthy
    humans and animals, this strain produces a
    powerful toxin, veritoxin, which can cause severe
    illness and death.
  • O represents the surface somatic polysaccharide
    antigen used for typing
  • H refers to the flagella atogen
  • 157H7 is singled out as the most likely to cause
    HUS and death

4
Vocabulary
  • Infectious dose- how many bacteria are necessary
    to infect and organism
  • Attack rate- the number of individuals exposed to
    and infectious dose who contract the disease
  • Sequelae- the outcome of the infection
  • Transmissible- food born diseases are
    transmissible by the fecal-oral route.
  • Variability- there is variability in the organism
    and the host.
  • Food matrix- the human intestinal system lives in
    permanent association with many types of
    microorganisms. The diet of the host,
    physiological state and genetics of the host
    affects the microorganisms

5
Background
  • First identified in 1982
  • 1992-1993 Jack in the Box food chain outbreak had
    500 laboratory-confirmed infections or deaths
  • 1996 Odwalla juice outbreak illness affected 45
    people
  • 1996, 3000 cases linked to radish sprouts in
    school lunch program
  • 2000, 2300 became ill, 7 deaths from water
    contaminated with E. coli from flooding

6
5 Year Trends in Colorado
  • www.cdphe.state.co.us/dc/EIP/eco.asp
  • Escherichia coli O157H7 is a Shiga toxin
    producing bacterium that can cause illness
    ranging from mild intestinal illness to severe
    kidney complications. Other Shiga toxin
    producing serotypes (e.g. O111 and O26) are also
    in the family of enterohemorrhagic E. coli and
    can cause similar disease.

7
How is it spread?
  • The organism can be found in the intestines of
    healthy cattle. The meat can be contaminated
    during slaughter.
  • Can be mixed into beef when it its ground into
    hamburger.
  • Bacteria on cows udders or on equipment can get
    into raw milk
  • It can contaminate fruits and vegetables from
    contact with manure used as fertilizer
  • Drinking water contaminated with sewage can carry
    the bacteria
  • The infectious dose is usually under 100
    organisms
  • Can be spread by person to person contact

8
Who does it affect?
  • E. coli O157H7 generally affects the young
    (including teens) and the elderly

9
What are the symptoms?
  • Diarrhea and malaise
  • Hemorrhagic colitis(HC) or bloody diarrhea and
    abdominal cramps
  • Lasts for 5-10 days usually
  • Infection may proceed to Hemolytic Uremic
    Syndrome (HUS), a severe cytopathic attack on the
    kidneys requiring intensive care and dialysis.
    Red blood cells are destroyed requiring blood
    tranfusion

10
Treatment
  • Most persons recover without antibiotics or
    specific treatment in 5-10 days.
  • Some antibiotic treatments cause kidney
    complications
  • Antidiarrheal agents should be avoided

11
Prevention
  • Cook all beef thoroughly (with no pink in center)
  • Avoid eating undercooked meat at restaurants
    (send it back)
  • Keep cooking area clean, wash your hands with hot
    soapy water
  • Keep raw meat away from read-to eat foods
  • Drink pasteurized milk and juices
  • Wash fruits and vegetables
  • Avoid swallowing lake or swimming pools water

12
References
  • Center for Disease Control, June 2001
  • http//www.cdc.gov/ncidod/dbmd/diseaseinfo/escheri
    chiacoli_g.htm (Search under What is Escherichia
    coli O157H7)
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