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General Pathology: Introduction to the Course

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General Pathology: Introduction to the Course Lorne Holland, M.D. Lorne.Holland_at_ucdenver.edu General Information COURSE DIRECTOR: Lorne Holland, M.D. Leprino Office ... – PowerPoint PPT presentation

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Title: General Pathology: Introduction to the Course


1
General PathologyIntroduction to the Course
  • Lorne Holland, M.D.
  • Lorne.Holland_at_ucdenver.edu

2
General Information
  • COURSE DIRECTOR
  • Lorne Holland, M.D.
  • Leprino Office Building, Main Laboratory- Rm
    280
  • Email Lorne.Holland_at_ucdenver.edu
  • Office (720) 848-7050
  • ADMINISTRATIVE COORDINATOR
  • Jaime Kean
  • Building A01 Room L15-2203
  • Email Jamie.Kean_at_ucdenver.edu
  • Phone (303) 724-3905

3
Map
Leprino Office Building
Parking Garage
4
Exams
  • Sample questions will periodically be posted on
    Blackboard with answers following shortly
  • Before each exam there will be a QA session
  • This is an opportunity for you to ask questions
    about the material
  • This is not meant to be a formal review of all
    lecture material
  • For best responses, please send me your
    question(s) a day or two in advance so I know
    what to expect

5
Exams
  • Multiple-choice, single best answer
  • 2-3 questions per lecture
  • Mid-October and December 17th
  • 2nd exam is cumulative with approximately 80 new
    and 20 old
  • Exams will be timed with 1.5 minutes allotted for
    each question

6
Exams
  • How much does a normal human head weigh?
  • More than twice the average orange
  • Between 4.4 and 5.3 kilograms
  • Hair is typically 0.2 to 1.1 of head weight
  • It would weigh only 1/6th as much on the moon

7
Exams
  • Review session immediately after
  • Answers will be projected
  • Your chance to ask questions
  • Only opportunity to review test answers

8
Exams
  • Grading
  • Tests are sent to the computer center for grading
    where they calculate statistics for each question
  • A few questions will have bad numbers and will
    be thrown out
  • Too hard or too easy
  • Random answer pattern

9
Other Tests
  • Independent study questions
  • Posted on Blackboard and due Sept 28th
  • May collaborate, but each student must submit
    their own answers
  • Remember, this material is fair game for both
    exams
  • Periodic, unannounced quizzes
  • Multiple-choice, single best answer and/or short
    answer
  • You can use class notes and textbook
  • Students not present when the quizzes are handed
    out will receive a zero
  • Lowest quiz score will be dropped

10
Objectives
  • Each lecture will have a set of objectives
  • This is the bare minimum you should be getting
    out of each lecture
  • If you can not perform the objectives then it is
    unlikely you will pass
  • If you only know material specifically addressed
    by the objectives, you will probably pass, but
    only barely (70-80)

11
Odds and Ends
  • Lecture handouts should be available on
    Blackboard 48 hrs before lecture
  • Exam dates will be firm, but lectures may
    occasionally move around a bit. You should have
    at least 24 hrs warning.
  • Please address questions directly to the
    lecturer. If you do not receive a response
    within 48 hrs then let me know
  • Evaluations after each test. Please complete
    them so I know what is working and what is not

12
Scope of Pathology
Pathology
Clinical
Experimental
Anatomic
laboratory medicine
13
Scope of Pathology
Pathology
Clinical
Experimental
Anatomic
Pathogenesis
Etiology
Epidemiology
14
Scope of Pathology
Pathology
Clinical
Experimental
Anatomic
Surgical
Gross / Micro
Gross / Micro
Autopsy
Microscopic
Cytology
Hematopath
Microscopic
15
Scope of Pathology
Pathology
Clinical
Anatomic
Experimental
Chemistry
Urinalysis
Hematology
Serology
Microbiology
Virology
Molecular
T.D.M.
Toxicology
Coagulation
Transf. Med
Point of Care
Flow Cytometry
16
Quick Guide to Microscopy
  • Unless otherwise stated, pictures in books and
    lecture and hemotoxylin and eosin (HE)
  • Proteins and starch stain pink
  • Nucleic acids (DNA, RNA) stain blue
  • Air, water, sugar and lipids do not stain at all
  • Naturally colored materials, black, brown, green

17
Quick Guide to Microscopy
18
Quick Guide to Microscopy
19
Other Colors
  • Golden (yellow/brown/green)
  • Bile
  • Brown
  • Hemosiderin, lipofuschin (iron)
  • Black
  • Carbon
  • Melanin

20
Special Stains
  • PAS ? starch/sugar
  • Prussian Blue ? iron
  • Oil Red O ? lipids

21
Immunohistochemistry
  • Produce antibodies to specific molecules, usually
    proteins
  • Attach a marker of some kind to the antibody
  • Wash a tissue section with the labeled antibody

22
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23
Questions?
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