Bivalirudin is Cleaved by Thrombin so that there is a Rapid Return to Hemostasis and a Safety Advantage

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Bivalirudin is Cleaved by Thrombin so that there
is a Rapid Return to Hemostasis and a Safety
Advantage
Angiomax (bivalirudin) is cleaved by thrombin,
allowing thrombin to quickly recover hemostatic
activity upon discontinuation of Angiomax. The
natural reversibility and the short, 25-minute
half-life may explain the significantly lower
bleeding rates seen in clinical trials.
Heparins effects on platelets and its
reappearance as it dissociates from cells and
proteins may explain the prolonged bleeding risk
following discontinuation of heparin, when a
return to normal hemostasis is essential.
Angiomax Prescribing Information, June 14 2005.
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