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Glycolysis, glycogenesis, and glycogenolysis

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Glycolysis, glycogenesis, and glycogenolysis Embden-Meyerhoff pathway (glycolysis) Blood glucose uptake Lactate metabolism Glycogenesis (glycogen formation) – PowerPoint PPT presentation

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Title: Glycolysis, glycogenesis, and glycogenolysis


1
Glycolysis, glycogenesis, and glycogenolysis
  • Embden-Meyerhoff pathway (glycolysis)
  • Blood glucose uptake
  • Lactate metabolism
  • Glycogenesis (glycogen formation)
  • Glycogenolysis (glycogen breakdown)
  • Regulation of glycogenolysis
  • Glycogen use during exercise

2
Glycolysis
Brooks et al.
3
Glycolysis
Glucose uptake role of insulin
Thong et al., Physiology 20 271, 2005
4
Glycolysis
Glucose uptake role of insulin
Brooks et al.
5
Glycolysis
Glucose uptake role of exercise
Rose and Richter, Physiology 20 260, 2005
6
Glycolysis
Brooks et al.
7
Glycolysis
Functions of glycolysis 1. Produce
pyruvate/lactate (oxidative substrates) 2.
Produce small amount of ATP (2-3 net) 3.
Produce small amount of H (2 pairs)
Murray et al., Harpers Biochemistry, Lange, 1996
8
Glycolysis
Brooks et al.
9
Glycolysis
  • Shuttles for moving reducing equivalents from the
    sarcoplasm into the mitochondria
  • Malate-aspartate shuttle
  • Glycerol phosphate shuttle
  • (Intracellular) Lactate shuttle
  • mMCT mitochondrial monocarboxylate transporter

Juel and Halestrap, J Physiol 517 633, 2000
10
Glycolysis
(Extracellular) lactate shuttle
Brooks et al.
11
Glycolysis
Cori cycle
Brooks et al.
12
Glycolysis
Blood lactate during exercise
Seeherman et al., Resp Physiol 44 11, 1981
13
Glycolysis
Blood lactate during exercise
Brooks et al.
14
Glycogenesis
Brooks et al.
15
Glycogenesis
Glycogen synthase b (inactive)
(epinephrine, Ca2) ? Glycogen synthase
a (active) (insulin,? G-6-P)
Brooks et al.
16
Glycogenesis
Hultman et al., Muscle Metabolism during
Exercise, Plenum, 1971
17
Glycogenesis
Åstrand, Textbook of Work Physiology,
McGraw-Hill, 1970
18
Glycogenesis
Åstrand, Textbook of Work Physiology,
McGraw-Hill, 1970
19
Glycogenolysis
Phosphorylase a regulation 1. Pi 2.
Ca2 3. Catecholamine Phosphorylase b
regulation 1. 5'-AMP
Brooks et al.
20
Glycogenolysis
Phosphorylase regulation 1. Pi 2. Ca2
3. Catecholamine Phosphorylase b regulation
1. 5'-AMP
Brooks et al.
21
Glycogenolysis
Glycogen use during exercise
Brooks et al. 2nd ed., 1996
22
Glycogenolysis
Glycogen use during exercise
Saltin and Gollnick, Exercise, Nutrition, and
Energy Metabolism, Macmillan, 1988
23
Glycogenolysis
Glycogen use during exercise histochemical
myosin ATPase and periodic acid-Schiffs stains
Wilmore and Costill, Physiology of Sport and
Exercise, Human Kinetics, 2004
24
Glycogenolysis
Glycogen use during exercise
Saltin and Gollnick, Exercise, Nutrition, and
Energy Metabolism, Macmillan, 1988
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