PURINE & PYRIMIDINE METABOLISM - PowerPoint PPT Presentation

Loading...

PPT – PURINE & PYRIMIDINE METABOLISM PowerPoint presentation | free to download - id: 3d0bb1-M2I3N



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

PURINE & PYRIMIDINE METABOLISM

Description:

PURINE & PYRIMIDINE METABOLISM dr Agus Budiman * * * * * * * * * * * * * Nucleotide consists purine / pyrimidine base, ribose/deoxyribose and phosphates. – PowerPoint PPT presentation

Number of Views:564
Avg rating:3.0/5.0
Slides: 23
Provided by: ikma10fkm
Learn more at: http://ikma10fkmua.files.wordpress.com
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: PURINE & PYRIMIDINE METABOLISM


1
PURINE PYRIMIDINE METABOLISM
  • dr Agus Budiman

2
  • Nucleotide consists purine / pyrimidine base,
    ribose/deoxyribose and phosphates.
  • Nucleoside consists purine/pyrimidine base and
    ribose/deoxyribose.
  • Purine base contains adenine, guanine and
    hypoxanthine.
  • Pyrimidine base contains cytosine, uracil and
    thymine.

3
(No Transcript)
4
(No Transcript)
5
(No Transcript)
6
(No Transcript)
7
Biosynthesis of purine
  • It begins with PRPP(phosphoribosyl phosphate)
    synthesis and PRPP synthase. Afterwards PRPP
    glutamyl amidotransferase . Those 2 enzymes are
    the key regulatory enzymes for the purine
    synthesis. IMP is synthesized and could make AMP
    or GMP.
  • It happens in almost most cells cytosol except
    human brain,polymorphonuclear leukocytes and
    erythrocytes.

8
Purine salvage pathway
  • Liver is the major site of synthesis.
  • It contains phosphoribosylation by PRPP of free
    purine to form purine mononucleotide such as
    adenine to AMP( with APRT) and hypoxanthine /
    guanine to IMP/ GMP( with HGPRT).
  • It contains too phosphoryl transfer from ATP to
    purine ribonucleoside such as adenosine kinase
    catalyzes adenosine to AMP.

9
Reduction of ribonucleoside diphosphate to
deoxyribonucleoside diphosphate.
  • The enzyme is ribonucleotide reductase complex
    and active only when cells are activelyly
    synthesizing DNA. It requires thioredoxin,
    thioredoxin reductase and NADPH.

10
(No Transcript)
11
Pyrimidine synthesis
  • It starts with carbamoyl phosphate with carbamoyl
    phosphate synthase II ( in cytosol).
  • PRPP will involve later in synthesis.
  • Salvage pathway is not that important such as
    OPRT.

12
(No Transcript)
13
  • Purine and pyrimidine biosynthesis are
    coordinately regulated through PRPP.
  • In purine synthesis is regulated through the
    first and second enzymes.
  • In pyrimidine synthesis, carbamoyl phosphate
    synthase II is inhibited by UTP and purine
    nucleotides, but activated by PRPP. Aspartate
    transcarbamoylase inhibited by CTP but activated
    by ATP.

14
Purine Catabolism
  • Purines are catabolized to xanthine and uric acid
    in human.Uric acid then is secreted in urine.
  • Gout is an arthritis that has hyperuricemia.
  • Lesch-Nyhan syndrome and Von Gierke disease are
    disorder of this purine catabolism.

15
(No Transcript)
16
Pyrimidine catabolism
  • Pyrimidines are catabolized to ß-alanine and
    ß-aminoisobutyrate then secreted in urine.

17
(No Transcript)
18
(No Transcript)
19
(No Transcript)
20
(No Transcript)
21
(No Transcript)
22
(No Transcript)
About PowerShow.com