Chapter 8 Cell Adhesion Molecules (CAM)

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Chapter 8 Cell Adhesion Molecules(CAM)
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Contents
Chapter 8 Cell Adhesion Molecules

• Part? Membrane molecules of immune cell
• Part? Definition of leukocyte differentiation
• antigen and CD
• Part? Definition, classification and functions
• of adhesion molecules
• Part? Clinical application of CD and
• adhesion molecules

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Part? Membrane molecules of immune cell

• Receptors TCR, BCR, CR, CKR, FcR
• Class?and class? MHC molecules
• CD molecules CD1339
• Cell Adhesion Molecules

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Part? Definition of leukocyte differentiation
antigen and CD

• Leukocyte differentiation antigen Cell surface
  molecules expressed (or disappeared) during
  different developmental and differential phases,
  activation or inactivation process of blood cells.

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Part? Definition of leukocyte differentiation
antigen and CD

• Leukocyte differentiation antigen
• CD cluster of differentiation.
• The same differentiation antigen recognized by
  different monoclonal antibody from different lab
  are called CD.

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CDs which take part in T cell recognition,
adhesion and activation
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CDs which take part in B cell recognition,
adhesion and activation
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Part? Definition, classification and
functions of adhesion molecules
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?. Definition

• Cell adhesion molecules (CAMs) are cell surface
  proteins involved in the interaction of cell-cell
  or cell-extracellular matrix.
• CAMs take effect by the binding of receptor and
  ligand.

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?. Classification

• Integrin family
• Selectin family
• Immunoglobulin (Ig) superfamily
• Cadherin family
• Mucin-like family
• Other adhesion molecules

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1. Integrin family

• Integrins consist of a and ß chains.
• According to ß subunits, Integrins are divided
  into eight groups ß1- ß8
• VLA-4(Very Late Antigen-4)------VCAM-1
• LFA-1(Lymphocyte Function-associated
  Antigen-1)------ICAM-1,2,3
• MAdCAM-1 (Mucosal Addressin Cell Adhesion
  Molecule-1)
• TSP-1 ((Thrombospondin?1)????????1

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Integrin and platelet aggregation
(Karp, 2001)
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Integrins promote immune response
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2. Selectin family

• Selectins consist of one peptide chain.
• The three family members include E-selectin,
  L-selectin, and P-selectin.

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3. Ig superfamily(IgSF)

• The structure of these adhesion molecules
  resemble that of Ig.
• CD4, CD8, CD2(LFA-2), CD58(LFA-3), VCAM-1,
  ICAM-1,2,3

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4. Cadherin family

• E-cadherin------ Epithelia cell
• N-cadherin------ Nerve cell
• P-cadherin-------Placenta

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5. Mucin-like family CD34, GlyCAM-1(glycosylat
ion dependent cell adhesion molecule-1)
PSGL-1(P-selectin glycoprotein ligand-1) 6.
Other adhesion molecules CD44
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?. Functions

• Participate in development and differentiation of
  immune cells
• CD2----LFA-3
• LFA-1----ICAM-1
• -------Participate in development and maturation
  of thymocytes.

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2.Participate in immune response and regulation
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3. Participate in the adhesion of leukocyte and
vascular endothelial cell during inflammation.
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• 4. Participate in lymphocyte homing
• Lymphoid stem cell migrate to central lymphoid
  organs.
• Mature lymphocyte migrate to peripheral lymphoid
  organs
• Recirculation of lymphocytes
• Lymphocyte migrate to the sites of inflammation

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5. Participate in regulation of apoptosis

• Integrins inhibit cell apoptosis