What is a Stem Cells ??? - PowerPoint PPT Presentation

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What is a Stem Cells ???

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Stem cells – PowerPoint PPT presentation

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Title: What is a Stem Cells ???


1
Stem cells ???? ?????????????? ??????????????????
???????????????? ????????????????
??????????????????????????????????????????
2
Stem cells ???????????????????????? cells
????????? ???????????
  • 1. ???? unspecialized cells ??????????? cells
    ??????????????????????? cells ???????????????

3
  • 2. ???????????????????????? ??????????????????????
    ??????? ?????????????

4
  • 3. ???????????????????????????????????????????????
    ?????????????? ??????????????????????????

5
??????????? Stem Cells
  • ??????????????????????????????????????? ,
    ?????????? ???? ????????????????????????????????
    ?????????? stem cells ????????????????????????????
    ?

6
???????????? Stem Cells
7
  • Stem Cells???????? 2 ???????????????????? ???
  • ??????????????????? (Embryonic stem cell)
  • ??????????????????? (adult stem cell)

8
??????????????????? (Embryonic stem cell)
9

???????? stem cells ??????????????? ??????? 2
?????????? ??? 1.?????????????????????
Blastocyst ??? 2. ??????????????
10
  • 1.????????????????????? Blastocyst
  • ????????????????? (Inner cell
    mass)???????????????????? ????????????? 5-7 ???
  • 2. ??????????????
  • ????????????? 2 ??? ???
  • 1. Reproduction Cloning ???????????????????????
    ?????
  • 2. Therapeutic Cloning ????????????????????????

11
???????????????? (Adult stem cell ???? Somatic
stem cell ???? Mature stem cell)
12
Adult stem cell
  • ??????????????????????????????????????????????
    ???? ?? ???????? ????? ???????? ???

13
??????????? Embryonic stem cell ???Adult stem
cell
14
Human embryonic stem cells ?????????????????
specialized cells ?????????? ???
15
????????? Embryonic stem cell ????????????????
  • ?????????????????????????????????????????
  • inner cell mass ?????????? culture dish
  • (??????????????) ??????????????????
    ????????????????????????????
  • culture dish ???????????????
  • culture dish ????????????? ??????? 6 ????? inner
    cell mass ????????????? embryonic stem cell
    ????????????? ???????? embryonic stem cell line
    ??????????????????????????? ????
  • ?????????????? ????

16
  • 1. ?????????????????????????? ?????
    ????????????????????????????????????????????
    differentiation
  • 2. ?????????????????? ??? Oct-4 ?????????????
    transcription factor ???????????????????? gene
    (???????????? DNA) ???????????????????????????
    differentiation ???????? ??????????
  • 3. ?????????????????? ????????????????????????????
    ??????

17
  • 4. ??????????????????????????????
    ????????????????????
  • ???????
  • 5. ?????????????? pluripotent (??????
    differentiate ?????????????????????)
    ???????????????? differentiate ???????????
    ??????????????????????????????????????????
    ??????????????
  • ??????????????????????????? (teratoma)

18
Adult stem cell
  • Adult stem cell ???? somatic stem cell
    ?????????????????????????? ??????????????????????
    ???? ???? ???????? ????????? ?????????? ???????
    ?????? ??????????????????? differentiate ??????
    specialized cell ????????????? ???????????????
    ??? ??????????????????????????????????????????
    ??????????????????????????? adult stem cell
    ????????????????????? ????????????????????????????
    ???????????????????????????????????

19
  • ??????????? adult stem cell ??????????????????????
    ?1. ???????????????? molecular marker
    ?????????????????????????? specialized
    cell??????
  • 2. ??????????????????? ???????????????????????????
    ???????????????????????? ????????????????????????
    ????????????????????????????????
  • 3. ??????????????????? ???? growth factor ???????
    gene ?????????????? ??????????????????
    differentiate ?????????????????

20
?????????????
  • 1. Thomson J.A., et al. Science. 1998 282(5391)
    1145.
  • 2. Gearhart J.D., et al. Proc. Natl. Acad. Sci.
    1998 95 13726-13731.
  • 3. Stem cell research climate. The scientist.
    June 27, 2003.
  • 4. http//stemcells.nih.gov
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