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Funding opportunities at NIH, the review process and thoughts related to achieving success

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Funding opportunities at NIH, the review process and thoughts related to achieving success March 11, 2009 NYU Stephen Korn, Ph.D. Director of Training and Career ... – PowerPoint PPT presentation

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Title: Funding opportunities at NIH, the review process and thoughts related to achieving success


1
Funding opportunities at NIH, the review process
and thoughts related to achieving success March
11, 2009 NYU
Stephen Korn, Ph.D. Director of Training and
Career Development NINDS, NIH
2
  • Preliminary Musings
  • Some Factual Stuff
  • Some Statistics
  • More Musings

3
As of November, 2008 Its a great time to be a
new investigator
4
Now Its still a great time to be a new
investigator for most of you
5
  • Opportunities to do science are fantastic
  • Fellowship success rates good (20-45)
  • Career Award success rates quite good (35-40)
  • K99/R00 was created (20)
  • Higher paylines than for established
    investigators
  • Targets to be met
  • From FY07 to FY09, 1500 R01 awards per year
    made to new investigators (128 at NINDS alone
    25-30tile)
  • Directors New Innovator Award created
  • Up to 1.5M over 5 years
  • 61 awards made in 2007, 2008

6
And it goes on
ESI (10 years since degree) vs New
investigator (no major NIH
grants yet)
7
Well talk about jobs later
8
HAVE A LONG-RANGE PLAN
  • Where are you going and how are you
  • going to get there.
  • Keep your eyes on the target and your
  • progress.
  • Be proactive.

9
What should you be thinking about when looking
for a training environment?
  • High quality science
  • Significant science
  • Exciting science
  • Strong mentorship
  • Great lab environment (people)
  • Institutional support for research
  • Support of independence

10
Some Factual Stuff
11
National Institutes of Health
  • 27 Institutes or Centers (ICs)
  • Each IC has its own mission
  • Each IC has its own budget
  • Each IC has its own activities
  • Each IC has its own ways of doing things
  • Each IC has its own personality

When youre planning to submit a grant, check
with program directors from different institutes
to determine their specific policies and interest
in your science.
12
Funding Opportunities for Trainees The Main Menu
13
Funding Opportunities
  • Fellowships
  • F30 NRSA for MD/PhDs
  • F31 NRSA predoc. fellowship (5 year max)
  • F32 NRSA postdoc. fellowship (3 year max)
  • Institutional Training Grants
  • T32 NRSA institutional training grant pre and
    postdoc
  • K12 Mentored clinical scientist development
    award

14
Funding Opportunities
  • Mentored Career Development Awards
  • K01 Mentored scientist IC-specific uses
  • K08, K23 For clinicians doing basic or
  • clinical research
  • K25 - Mentored quantitative research
  • Career Transition Awards
  • K99/R00 - Pathway to Independence Award
  • K22 Career Transition Award IC-specific

15
Funding Opportunities
  • Independent Career Development Awards
  • K02 Research Scientist Development
  • NINDS Clinicians only before R01
  • Others MD or PHD, Career Development
  • after R01
  • K24 Midcareer award in patient-oriented
    research

16
Some Relevant Characteristics of Different
Mechanisms
17
For all NRSA fellowships, and all K awards
except K99/R00, applicants must be a U.S. citizen
or permanent resident.
18
Predoc (F31) 1-5 years, primarily
stipend Postdoc (F32) 1-3 years, primarily
stipend ALL POSTDOCS should be applying K
awards generally 3 5 years, provide
salary, fringe, research costs and
protected time (most require
75 effort devoted to research) Details
for all mechanisms vary by IC
19
The K99/R00 Transition to Independence Award
20
  • What the K99/R00 was intended to do
  • Speed the transition to R01 and thus reduce the
    age of applicants getting 1st one
  • What the K99/R00 does
  • Facilitates the transition to a good academic
    position
  • Who gets the K99/R00
  • The most creative, scientifically sound,
    articulate postdocs

21
K99/R00
  • Must have less than 5 yrs. postdoc. res.
    experience
  • 2 years K99 (mentored)
  • 75 effort required
  • 90,000 total cost, up to 50,000 salary
  • Exceptions related to salary (MD, other)
  • 3 years R00 (independent)
  • must have tenure track or equivalent position
  • must get appropriate startup package
  • 75 effort on research required
  • 249,000 total cost

22
K99/R00
  • K99 phase (mentored)
  • IC-specific salary differences
  • IC-specific research expense differences
  • IC-specific duration differences
  • R00 phase (independent)
  • IC-specific duration differences
  • Administrative review undoubtedly
  • IC differences

In the program announcement, theres a web table
listing all of the IC-specific information. http/
/grants.nih.gov/grants/guide/contacts/pa-07-297_co
ntacts.htm
23
K99 Fundamentals
  • Open to U.S. and Non-U.S. Citizens
  • Both phases must be done in the U.S.
  • For NINDS, must do at least 1 full year
  • in K99 phase varies by IC
  • Can submit amended application, but
  • must be within 5 year rule
  • Must be in mentored position to apply

24
For the K99, reviewers are looking for the Duck
25
Research Grants for Independent Scientists
26
The Main R-series Grants
  • Large Research Grant (R01)
  • 4-5 years, 250,000 or more/yr
  • Exploratory Research Grant (R21)
  • High Risk/High Reward
  • 2 years, 275,000 total
  • Small Grant (R03)
  • 2 year max, 50,000/yr max
  • Generally not a good approach
  • Acad. Res. Enhancement Award (R15)
  • primarily undergrad institutions

27
The Main R-series Grants
  • Large Research Grant (R01)
  • 4-5 years, 250,000 or more/yr
  • Exploratory Research Grant (R21)
  • High Risk/High Reward
  • 2 years, 275,000 total
  • Small Grant (R03)
  • 2 year max, 50,000/yr max
  • Generally not a good approach
  • Acad. Res. Enhancement Award (R15)
  • primarily undergrad institutions

28
Other Funding for Independent Scientists
  • R41R44 (STTR/SBIR) Supports collaboration
    between researchers and small business
  • P-type (program projects and centers)
  • U-type (cooperative agreements)

29
Application Preparation and Review
30
What happens when you submit an application?
Center for Scientific Review
Scientific Review Group/ IC Review Branch
FUNDING DECISION
Program, NINDS
Advisory Council-NINDS
Institute Director
31
What is a study section (scientific review
group)?
32
Your application is reviewed at study section by
  • Experts
  • Non-experts
  • People who are reading lots of grants
  • People who want to be excited by science
  • People who will be irritated by a sloppy
    application

Submit a high quality application!
Have people review your application critically
WELL BEFORE submission
33
(No Transcript)
34
Hypothesis-Driven Research vs Discovery Science
35
What is required for a good training grant
application?
  • Significant research question
  • Clear hypotheses
  • Clear tests of hypotheses
  • Feasibility
  • Excellent career development plan
  • Excellent mentoring
  • Appropriate institutional support
  • High quality publications
  • Plans to evaluate progress

36
But some of this will change more later
37
Hypothesis-Driven vs. Discovery Science
38
The specific aims page is your hook Make it as
perfect as possible
39
Write clearly, coherently, logically DO NOT BE
BORING! DO NOT BE SLOPPY! DO NOT MAKE IT
DIFFICULT FOR THE REVIEWERS!
40
You may not be funded on the first
submission You may not even get a score!
41
DO NOT TAKE REJECTION PERSONALLY! PERSIST!
42
When you miss the funding range, respond to
reviewer comments appropriately
43
Things will change dramatically in the near
future
  • Length change 25 ? 12 pages for R01, Ks
  • Length change 10 ? 6 pages for Fs
  • Length changes for other mechanisms
  • Change in scoring system
  • More structured review
  • Change in review criteria
  • A2 eliminated only get 2 shots

http//enhancing-peer-review.nih.gov/calendar.html
Click on link to slides
44
Some Statistics
45
NIH-wide F Success Rates
46
apps
awrds
--------Success rates---------



F31 Statistics
47
F32 success rates
In FY08, NINDS fellowship success rate 22
48
Increase in the number of Fellowship (F31, F32)
applications, 2003 - 2007
49
K99/R00 NINDS
50
K99/R00 results thus far for NINDS
17 of the first 19 awardees (through awards made
1/2008) have jobs (2 are weighing offers) 3 of
those who got awards after 1/2008 have jobs
51
K99/R00 NIH-wide FY2007
52
NIH-wide Career Awards, 2008
K99 795 180
23 17,195,013
53
NIH-wide RPG Success Rates, FY2007
54
Keep in mind, success rates are underestimates
because of how theyre calculated Applicant
success rate is higher!
55
Miscellaneous Musings
56
A research career is a blast But you have to be
good
57
Evaluate yourself honestly (not what you wish,
but what is)
58
  • When you look around you, are you one of the
    best predocs or postdocs you know? If not, do you
    want to be? What do you want?
  • When you read your grant, do you think the
    leader in your field would be impressed?
  • If not, keep writing.
  • You must get rid of your ego and be
  • honest with regard to your writing
  • ? You must get help (from your mentor)

59
You are ultimately the person responsible for
your success You must have some first author
papers in good journals Interviews and lab
situations are two way streets you must get
what you need to succeed If you are in a bad
situation, get out
60
Remember to HAVE FUN HAVE A LIFE (those who
dont choose not to!)
61
And Keep your chin up and keep moving
forward Its bad all over right now just hang
in there Ok, lets talk jobs
62
If you have questions Email or Call Program
Director - questions related to science Training
Director (e.g. me at NINDS) - for questions
related to mechanisms, application preparation,
etc. Who you need to speak with will vary by
institute
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