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Alcohol Metabolism

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Alcohol Metabolism Jill Conan Carrie Darr Leanne Phillips Alcohol Also known as ethanol or ethyl alcohol Considered the same whether beverage is wine, beer or hard ... – PowerPoint PPT presentation

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Title: Alcohol Metabolism


1
Alcohol Metabolism
  • Jill Conan
  • Carrie Darr
  • Leanne Phillips

2
Alcohol
  • Also known as ethanol or ethyl alcohol
  • Considered the same whether beverage is wine,
    beer or hard liquor
  • Classified as a food but contains empty calories

3
Alcohol Digestion
  • Not digested like other foods
  • It can go directly into the bloodstream
  • Alcohol absorption throughout the GI tract
  • It is quickly distributed throughout the body

4
Alcohol Absorption
  • Can be absorbed into the bloodstream at
  • Mouth
  • Esophagus
  • Stomach
  • Small Intestine

5
Absorption in the Stomach
  • About 20 to 25 is absorbed
  • Factors that influence absorption
  • the rate of intake
  • presence of food
  • the rate of gastric emptying

6
Absorption in the Small Intestine
  • 75-80 is absorbed. 
  • This absorption is extremely rapid.

7
Alcohol Metabolism Pathways
  • Alcohol Dehydrogenase (ADH)
  • Stomach
  • Liver
  • Microsomal Ethanol Oxidizing System (MEOS)
  • Liver

8
ADH Pathway
  • In the cytoplasm, ADH converts ethanol to
    acetaldehyde
  • CH3-CH2-OH NAD CH3-CHO NADH
    H
  • Ethanol ADH
    Acetaldehyde

9
ADH Pathway
  • In the mitochondria, acetaldehyde is converted to
    acetate and in turn acetate is converted to
    acetyl CoA which leads the two-carbon molecule
    into the TCA cycle
  • CH3-CHO NAD CH3-COOH
    NADH H
  • Acetaldehyde ADH Acetate

10
Microsomal Ethanol Oxidizing System (MEOS)
  • Alternate pathway used, in addition to ADH, when
    alcohol intake is excessive
  • End products include
  • Ethanol ? acetaldehyde
  • NADPH H ? NADP
  • No ATP formation Energy Wasteful

11
ADH and MEOS Pathway
  • Ethanol Acetaldehyde

  • NAD

  • NADH
  • Acetyl CoA

12
Effects on body
  • LIVER
  • Fatty liver
  • Cirrhosis
  • Hypoglycemia (low blood sugar)

13
Effects on Body (cont)
  • Central Nervous System
  • When intoxication occurs it affects emotional and
    sensory function, judgment, memory and learning
    ability
  • Smell and taste are dulled
  • Ability to withstand pain increases
  • Long term effects include tolerance, dependency
    and irreversible damage
  • Brain is most affected

14
Effects on Body (cont)
  • Blood
  • Blood-Sludging
  • Anemia
  • Weakness of bone structure
  • Decrease resistance to infection and inability to
    fight off infections

15
Effects on Body (cont)
  • Muscles
  • Reduced blood flow. Causing muscle weakness and
    deterioration
  • Irregular heartbeat, sluggish heart, and muscle
    aches

16
Effects on Body (cont)
  • Endocrine
  • Sedates glands
  • Sexual functioning
  • -Low doses decrease inhibitions
  • -High doses decrease sexual functioning for
  • men and women

17
References
  • Advanced Nutrition and Human Metabolism, 3rd
    Edition. J. Groff, and S. Cooper, Wadsworth
    Publishing Co. 1999.
  • http//www.hsc.wvu.edu/som/cmed/alcohol/metabolism
    .htm
  • http//afpafitness.com/articles/AlcoholMet.htm
  • http//www.oregoncounseling.org/ArticlesPapers/Doc
    uments/ETOHBIOFx.htm
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