SCIENTIFIC COMMUNICATION IN THE 21st CENTURY

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SCIENTIFIC COMMUNICATION IN THE 21st
CENTURY
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CHARACTERISTICS OF JOURNALS

• PRINTED JOURNALS
• ? SCOPE
• ? Broad scope, high quality
• ? Nature, Science
• ? Specialized, high quality
• ? Journal of immunology
• ? Highly specialized, high quality
• ? Molecular Endocrinology

• IDEAL ELECTRONIC JOURNAL
• ? SCOPE
• ? Broad scope, high quality
• ? Specialized, high quality
• ? Highly specialized, high quality
• ? REQUIREMENTS
• ? Editors in various disciplines
• ? Classification of the subject matter

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CHARACTERISTICS OF JOURNALS

• PRINTED JOURNALS
• ? READERS
• ? Large number
• ? Nature, Science
• ? Limited number
• ? Journal of immunology
• ? Limited number
• ? Molecular Endocrinology

• IDEAL ELECTRONIC JOURNAL
• ? READERS
• ? Large number
• ? REQUIREMENTS
• ? Available as full text on line

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CHARACTERISTICS OF JOURNALS

• PRINTED JOURNAL
• ? PEER REVIEW
• ? Lack of standardization
• ? Limited contribution

• IDEAL ELECTRONIC JOURNAL
• ? PEER REVIEW
• ? Standardization
• ? Broad contribution

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CHARACTERISTICS OF JOURNALS

• PRINTED JOURNALS
• ? TIME REQUIREMENTS FOR PUBLICATION
• ? 3-12 Months

• IDEAL ELECTRONIC JOURNAL
• ? TIME REQUIREMENTS FOR PUBLICATION
• ? 10-30 days
• ? REQUIREMENTS
• ? Reliable reviewers
• ? Use of E-mail
• ? Electronic transfer of manuscript
• ? Full commitment of editors

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CHARACTERISTICS OF JOURNALS

• PRINTED JOURNAL
• ? Archived

• IDEAL ELECTRONIC JOURNAL
• ? Non-archived

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CHARACTERISTICS OF JOURNALS

• PRINTED JOURNAL
• ? INABILITY TO EMBED SOUND
• ? INABILITY TO EMBED VIDEO
• ? INABILITY TO INTRODUCE INTERACTIVITY
• ? Inability to allow author-reader interactivity
• ? Inability to allow interactivity with data

• IDEAL ELECTRONIC JOURNAL
• ? ABILITY TO EMBED SOUND
• ? ABILITY TO EMBED VIDEO
• ? ABILITY TO INTRODUCE INTERACTIVITY
• ? Ability to allow author-reader interactivity
• ? Ability to allow interactivity with data (JAVA,
  VRML)

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CHARACTERISTICS OF JOURNALS

• PRINTED JOURNALS
• ? SEARCHING
• ? Inability to search the document for specific
  terms or for key words
• ? Inability to search for references related to
  the key words

• IDEAL ELECTRONIC JOURNAL
• ? SEARCHING
• ? Ability to search the document for specific
  terms or for key words
• ? Ability to search for references related to
  the key words

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CHARACTERISTICS OF JOURNALS

• PRINTED JOURNALS
• ? LINKING
• ? Inability to link to resources and databases
  regarding the subject
• ? Inability to link to previous
  manuscripts of the same author
  
  

• IDEAL ELECTRONIC JOURNAL
• ? LINKING
• ? Ability to link to resources and databases
  regarding the subject
• ? Ability to link to previous
  manuscripts of the same author

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CHARACTERISTICS OF JOURNALS

• PRINTED JOURNALS
• ? LINKING
• ? Lack of inability to link to corrections

• IDEAL ELECTRONIC JOURNAL
• ? LINKING
• ? Ability to link to corrections

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CHARACTERISTICS OF MANUSCRIPTS

• PRINTED JOURNALS
• ? UPDATING
• ? Lack of inability to update the reviews

• IDEAL ELECTRONIC JOURNAL
• ? UPDATING
• ? Ability to update the reviews

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IDEAL ELECTRONIC JOURNAL

• URL http//www.bioscience.org

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AN IDEAL ELECTRONIC JOURNAL

• URL http//www.bioscience.org

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MANUSCRIPTS IN FBS

• CATEGORIES OF THE
• MANUSCRIPTS
• RESEARCH ARTICLES IN BASIC SCIENCE
• REVIEWS IN BASIC SCIENCE
• RESEARCH ARTICLES IN CLINICAL SCIENCE
• REVIEWS IN CLINICAL SCIENCE
• TECHNICAL NOTES AND PROTOCOLS
• MULTIMEDIA-MEDICINE
• DATABASES
• PROCEEDINGS REPORTS

• SAMPLE MANUSCRIPTS
• D-Z. Wang, X. Hu, J. L-C. Lin, G.T. Kitten, M.
  Solursh, and J. J-C. Lin Differential displaying
  of mRNAs from the atrioventricular region of
  developing chicken hearts at stages 15 and 21
  Vol 1 pp a1-15 January 1, 1996
• J. L. Tilly The molecular basis of ovarian cell
  death during germ cell attrition, follicular
  atresia, and luteolysis Vol 1 pp d1-11 January
  1, 1996
• D. K. C. Cooper Xenotransplantation - State of
  the art Vol 1 pp d248-265 September 1, 1996
• S. Debernardi, M. Luzzana and Gianluca De
  Bellis Solid phase purification and SSCP
  analysis of amplified genomic DNA by capillary
  electrophoresis Vol 1 pp c1-3 January 1, 1996

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MANUSCRIPTS IN FBS

• A SAMPLE MANUSCRIPT
• 
  
• DIFFERENTIAL DISPLAY OF mRNAs FROM THE
  ATRIOVENTRICULAR REGION OF DEVELOPING CHICKEN
  HEARTS AT STAGES 15 AND 21
• Da-Zhi Wang, Xiaoyun Hu, Jenny L-C. Lin, Gregory
  T. Kitten, Michael Solursh, and Jim J-C. Lin.
• Department of Biological Sciences, University of
  Iowa, Iowa City, Iowa 52242-1324
• 2. Abstract
• 3. Introduction
• 4. Materials and Methods
• 5. Results
• 6. Discussion
• 7. Acknowledgements
• 8. References

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MANUSCRIPTS IN FBS

• A SAMPLE MANUSCRIPT
• ABSTRACT
• Calcium is essential for normal epidermal...
• INTRODUCTION
• Calcium is essential for normal epidermal
  differentiation (1).
• MATERIALS AND METHODS
• 1. Northern Blots
• 2. Nuclear run-on assays
• 3. Plasmids and DNA Sequencing.
• 4. Cell Culture and transfection
• 5. Reporter assays
• Northern blotting
• Total RNA was prepared according to the method of
  Chomczynski and Sacchi (13). Twenty µg total RNA
  per lane was electrophoresed through
  1agarose-formaldehyde gels. The RNA was then
  stained with Acridine Orange (Sigma , St Louis,
  MO)

• RESULTS
• Calcium treatment (1.2 mM) did not
  substantially...
• DISCUSSION
• Extracellular calcium increases involucrin
  mRNA levels in NHK in a...
• REFERENCES
• 94237893. Su MJ, Bikle DD, Mancianti ML, Pillai
  S. 1,25-Dihydroxyvitamin D3 potentiates the
  keratinocyte response to calcium. J Biol Chem
• 1994269(20)14723-9. (View Report format,
  MEDLARS format, ASN.1 format, 30 MEDLINE
  neighbors, 1 protein link , or 1 nucleotide link)

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EDITORS AND MANAGING EDITOR OF FBS

• EDITORS BASIC SCIENCE
• ? BIOCHEMISTRY
• DIANA BORASCHI, PhD
• RAFAEL FRANCO, PhD
• HISAO MASAI, PhD
• ? BIOINFORMATICS
• LEONARD LEIBOVICI, MD
• ? CANCER/ONCOLOGY
• ALAIN BLANCHARD, PhD
• ROBERT MORRIS FRIEDMAN, PhD

• EDITORS CLINICAL SCIENCE
• ? CENTRAL NERVOUS SYSTEM/EYE
• HANS J BIERSACK, MD, PhD
• ALLEN D ELSTER, MD
• VASSILIS E KOLIATSOS, MD
• ? CARDIOVASCULAR SYSTEM
• LAUREN R BOGLIOLI, MD
• ? CANCER/ONCOLOGY
• YASUHITO ABE, MD
• UGUR BERBEROGLU, MD
• HANS J BIERSACK, MD, PhD

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AN IDEAL ELECTRONIC JOURNAL

• URL http//www.bioscience.org

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AN IDEAL ELECTRONIC JOURNAL

• URL http//www.bioscience.org

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AN IDEAL ELECTRONIC JOURNAL

• URL http//www.bioscience.org

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SPECIAL ISSUES IN FBS

• DISCIPLINES

• PROCESSES
• AND EVENTS

• MOLECULES

? Calreticulin ? Complement Protein ?
CRH ? DnaA ? Fas/Apo1 ? Fcgamma Receptor
? GABA Receptor ? Galactosyltransferase ?
Involucrin ? NADPH Oxidase ? Phox Family ?
Tau Protein ? Vitamin D
? Apoptosis ? Mitochondrial Transport ? Sperm
Function ? Mycoplasma ? Follicular atresia

• ? Cardiology
• ? Cellular Molecular Biology
• ? Dermatology
• ? Female Reproductive Medicine
• ? Gastrointestinal System
• ? Immunology
• ? Male Reproductive Medicine
• ? Microbiology
• ? Msculoskeletal System
• ? Neurology
• ? Nephrology
• ? Pharmacology
• ? Radiology
• ? Technology

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SPECIAL ISSUES IN FBS
SPECIAL ISSUE MALE
REPRODUCTIVE MEDICINE FROM SPERMATOGENESIS TO
SPERM FUNCTION AND MODULATION OF FERTILITY

• TABLE OF CONTENTS
• PREFACE
• R. K. Naz, Editor
• S. Tabibzadeh, Series Editor
• CREM A transcriptional master switch during
  the
• spermatogenesis differentiation program
• F. Nantel and P. Sassone-Corsi
• Vol 1 pp d266-269 September 1, 1996
• Interaction of human spermatozoa with the
  zona pellucida of
• oocyte Development of the acrosome reaction
• P. Morales, and M. Llanos
• Vol 1 pp d146-160 August 1, 1996
• The cAMP-dependent kinase pathway and human
  sperm
• acrosomal exocytosis
• C. De Jonge

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NEWS IN FBS

• NEWS
• ORGANS AND ORGAN SYSTEMS
• BREAST ( BRCA1)
• CARDIOVASCULAR SYSTEM (
  Hemoglobin, Cardiomyopathy)
• DISEASES
• ALZHEIMER'S DISEASE ( Presenilins)
• CANCER (BRCA1, Np16INK4a,
  BCC gene, CD44, MPM, P53)
• PROCESSES AND EVENTS
• AGING (Werners syndrome)
• BIOLOGICAL CLOCKS (Interval timer,
  Circadian clock, Molecular
  pacemekaers)
• OTHERS
• CELL AND MOLECULAR BIOLOGY (BCL-X,Telomerase)

• NEWS SAMPLE

p53 is a nuclear phosphoprotein which acts as a
tumor suppressor. The gene for p53 is located on
the short arm of chromosome 17 at
17p13.105-p12. T p53 protein is undetectable or
is present at a low level in resting cells. On
the other hand, it is found in large amounts in
a wide variety of transformed cells, and in many
actively proliferating, and nontransformed cells.
The function of this protein is poorly
understood. However, it is thought that it may be
implicated in the regulation of the cell
cycle Jay, 1981 p53 transformation-related
protein detection of an associated
phosphotransferase activity. Proc Natl
Acad Sci U S A 78, 2932-6 (1981) 81247402
(View Citation format,Abstract format,MEDLARS
format,ASN.1 format,Save As..., or 30
Related MEDLINE citations) Neiman, 1981
Independent recombination between avian leukosis
virus terminal sequences and host DNA in
virus-induced proliferative disease. Proc
Natl Acad Sci U S A 78, 1896-900 (1981)
81199562 (View Citation format,Abstract
format,MEDLARS format,ASN.1 format,Save
As..., or 30 Related MEDLINE citations)
24
THE KNOWLEDGE CENTER

• URL http//www.bioscience.org

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BOOKS AND LECTURES IN FBS

• A SAMPLE BOOK
• F Endometriosis - The '90s Outlook
• About the Author
• Cover

• TABLE OF CONTENTS
• Introduction
• Q. What is endometriosis?
• Q. How common is endometriosis?
• Q. Is there any age group which is more
  prone to
• endometriosis?
• Q. Is endometriosis based on a genetic or
  familial factor?
• Q. Is it true that women who have their
  tubes tied are
• protected against endometriosis?
• Q. Is it true that intercourse during the
  menstrual cycle
• increases the risk of endometriosis?
• Q. At the time of my laparoscopy, my doctor
  was not able to
• get a biopsy. Is the physical appearance
  of endometriosis
• adequate for diagnosis?
• Q. Why does endometriosis seem to be
  discussed more in
• recent years?
• Q. Is it true that endometriosis is more
  common in some
• races?
• Q. What is endometriosis?

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GENE KNOCKOUT DATABASE IN FBS

• DATABASE OF GENE KNOCKOUTS
• ? IMPACT OF GENE KNOCKOUTS ON PHENOTYPE
• ? GENE KNOCKOUTS CLASSIFIED ACCORDING
• TO THE VIABILITY OF THE MICE
• ? GENE KNOCKOUTS WHICH ARE COMPATIBLE
• WITH VIABILITY
• ? GENE KNOCKOUTS WHICH RESULT IN
• PRENATAL MORTALITY
• ? GENE KNOCKOUTS WHICH RESULT IN
• POSTNATAL MORTALITY

• ? GENE KNOCKOUTS LISTED ALPHABETICALLY
• ACCORDING TO THE NAME OF THE GENE
• ? 5-Lipoxygenase
• ? Acrosin
• ? Alpha 1 (IX) collagen
• ? Alpha calcium-calmodulin kinase II (alpha
  CaMKII)
• ? Amyloid precursor protein (APP)
• ? Angiotensinogen
• ? ApoC-III
• ? Apo B
• ? Apo E
• ? Bax
• ? Brain-derived neurotrophic factor (BDNF)
• ? Beta 1 integrin
• ? Beta 2-microglobulin
• ? B7
• ? Bcl-2
• ? Bcl-x

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GENE KNOCKOUT DATABASE IN FBS

• 5-LIPOXYGENASE
• ? Normal development
• ? Healthy
• ? Normal reaction to endotoxin shock
• ? Normal inflammatory response to phorbol ester
• ? Normal acute inflammatory response induced by
  arachidonic
• acid (Goulet et al., 1994)
• ? Selective opposition to certain inflammatory
  insults
• ? Resistance to the lethal anaphylaxis and
  shock induced by
• platelet-activating factor
• ? Reduced inflammatory response to arachidonic
  acid (Chen et
• al., 1994)
• ? Inability to synthesize detectable levels of
  leukotrienes
• Chen et al., 1994
• Goulet et al., 1994

• Chen XS, Sheller JR, Johnson EN, Funk CD Role
  of leukotrienes revealed by targeted disruption
  of the 5-lipoxygenase gene. Nature 1994 Nov
  10372(6502)179-82
• ABSTRACT
• Leukotrienes constitute a class of potent
  biological mediators of inflammation and
  anaphylaxis (for reviews see refs 1 and 2). Their
  biosynthesisderives from 5-lipoxygenase-catalysed
  oxygenation of arachidonic acid in granulocytes,
  macrophages and mast cells. To examine the
  physiological importance of leukotrienes, we have
  disrupted the 5-lipoxygenase gene by homologous
  recombination in embryonic stem cells.
  5-Lipoxygenase-deficient (5LX-/-) mice develop
  normally and are healthy. They show a selective
  opposition to certain inflammatory insults.
  Although there is no difference in their reaction
  to endotoxin shock, the 5LX-/- animals resist the
  lethal effects of shock induced by
  platelet-activating factor. Reaction to ear
  inflammation induced by phorbol ester is normal,
  whereas inflammation induced by arachidonic acid
  is markedly reduced. Contrasts were also found in
  two models of leukocyte chemotaxis in vivo. The
  phenotype of 5LX-/- mice under injurious insult
  identifies the role for leukotrienes in the
  pathophysiology of select inflammatory states.

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TUMOR ATLAS DATABASE IN FBS

• Clicking on the organs on the right side will
  access
• the list of images. Clicking on the organs on the
  left
• side will access the information and resources.

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TUMOR ATLAS DATABASE
DUCT CELL CARCINOMA OF THE BREAST
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HEART ATLAS DATABASE
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AMINO ACID ATLAS DATABASE
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ELEMENT DATABASE
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BIOLOGIC CALCULATOR
May 2006
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BIOMALL

• URL http//www.bioscience.org

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BIOMALL
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FBS MORE THAN A JOURNAL A VIRTUAL LIBRARY

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RESEARCH TOOLS

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RESEARCH TOOLS
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SUBSCRIPTION TO FBS

• ? ELECTRONIC PLATFORM
• ? IP ACCESS
• ? PASSWORD ACCESS
• ? CD-ROM

? PRINTED JOURNAL ? SPECIAL
ISSUES ? CD-ROMs ? PRINT
67
VISIT FBS

• ? VISIT FBS AND ENJOY A WORLD OF SCIENCE
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