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Stem cell technologies Current state Future promise

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More research is needed to find the ways to actually use stem cells for ... is likely that research involving non-approved stem cell lines will be ... – PowerPoint PPT presentation

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Title: Stem cell technologies Current state Future promise


1
Stem cell technologies Current state Future
promise
  • Where UCI fits in to the Post Prop. 71 world of
    biotechnology development in California

2
Proposition 71 Purpose and Intent
  • Create California Institute for Regenerative
    Medicine.
  • Oversight by Independent Citizens Oversight
    Committee (ICOC).
  • Support the development of technologies involving
    pluripotent stem cell and progenitor cell.
  • Prohibit human reproductive cloning

3
Proposition 71 Funds
  • Funding details
  • Authorizes an average of 295 million per year in
    bonds over a 10-year period, 3 billion total
  • In any year, no more than 350 million in bonds
    to be issued
  • If less than 350 million is issued in any year,
    the remaining permitted amount may be carried
    over to one or more subsequent years

4
Proposition 71 Research facilities
  • Research facilities that can be used for research
    on non-approved lines are a priority.
  • Accordingly, up to 10 of the funds will be
    used to build scientific and medical research
    facilities of nonprofit entities.
  • These are to be constructed in the first five
    years, with priority given to facilities that can
    be brought on line within the first 2 years.
  • Funding through Prop. 71 for development of
    facilities requires a 20 match.

5
Proposition 71 Oversight
  • The ICOC must meet in an open meeting format.
  • Closed sessions may be conducted when discussing
  • Matters involving information relating to
    patients or medical subjects. Matters involving
    confidential intellectual property or work
    product
  • Matters involving prepublication, confidential
    scientific research or data
  • Matters concerning the appointment, employment,
    performance, compensation, or dismissal of
    institute officers and employees

6
Proposition 71 Scientific and Medical Working
Groups
  • Scientific and Medical Research Funding Working
    Group.
  • Scientific and Medical Accountability Standards
    Working Group.
  • Scientific and Medical Research Facilities
    Working Group.

7
A primer on Human Embryonic Stem Cells
Blastocyst - from In Vitro Fertilization Clinic
Blueprint cells
Inner Cell Mass (Stem Cells)
A Blastocyst is a hollow ball of cells with a
small clump of stem cells inside
8
Human Embryonic Stem Cells
Pipette
Blueprint cells
Stem Cells
To remove the stem cells, the Blastocyst is
opened and the stem cells removed with a pipette
9
Human Embryonic Stem Cells
Pipette
Blueprint cells
Stem Cells
Stem Cells
To remove the stem cells, the Blastocyst is
broken open and the stem cells removed with a
pipette(an ultra thin glass tube)
The stem cells are placed in a dish and are fed
and cared for (each blastocyst 1 stem cell
line)
Pipette
Petri Dish
10
Growth factors
Chemical cues
Petri Dish
Stem Cells
Pancreatic Islet
Muscle cell
Neuron
Different chemicals / molecules are added to the
stem cells to make them become specific types of
cells.
11
(No Transcript)
12
Somatic Cell Nuclear Transfer or Therapeutic
Cloning
Donor Egg
Skin Cell
Nucleus (DNA)
Nucleus (DNA)
Needle
Needle
Stem Cells
Chemicals and Growth Factors
Pancreatic Islet
Neuron
Muscle cell
Dividing cells
13
The vision for UCIs Stem Cell Center Stem
cell therapies for neurological disorders
  • Brain and spinal cord injury.
  • Stroke.
  • Neurodegenerative diseases
  • Parkinsons Disease
  • Huntingtons Disease
  • Alzheimers Disease
  • Multiple Sclerosis
  • Lou Gerhigs Disease (ALS)

14
Neurological disorders involve the loss of
particular cell types in the nervous system
  • Brain and spinal cord injury and stroke (loss of
    nerve cells and myelin-forming oligodendrocytes).
  • Neurodegenerative diseases
  • Parkinsons Disease (loss of dopamine-containing
    nerve cells in the brainstem).
  • Huntingtons Disease (loss of nerve cells in the
    striatum).
  • Alzheimers Disease (loss of nerve cells in the
    cerebral cortex).
  • Multiple Sclerosis (loss of myelin-forming
    oligodendrocytes).
  • Lou Gerhigs Disease-ALS (loss of motor neurons
    from the spinal cord).
  • The vision To use embryonic stem cells to
    restore the cells that are lost as a result of
    injury or neurodegenerative diseases.

15
Goal 1 to make stem cells into nerve cells
Stem Cells
Blastocyst -
Pipette
Blueprint cells
Petri Dish
Stem Cells
Blueprint cells
Stem Cells
The stem cells are treated with factors to cause
them to differentiate into particular cell types
Stem cells differentiated into neurons
16
Goal 2 To discover how to make stem cells
integrate into neural circuits.
Oligodendrocyte
Nerve cell (neuron)
More research is needed to find the ways to
actually use stem cells for therapeutic
applications.
17
At the RIRC, a therapy is being developed to use
stem cells to replace myelin-forming cells
Myelin-forming cells (oligodendrocytes) die as a
result of spinal cord injury, resulting in the
loss of myelin (insulation) from nerve
fibers. An important potential therapeutic
strategy Replace myelin-forming cells using
stem cells that differentiate into
oligodendrocytes.
18
RIRC scientists have succeeded in developing ways
to produce oligodendrocytes from human ES cells
and have shown that they can restore myelin after
spinal cord injury in experimental animals.
Stem cells are first differentiated to the neural
lineage.
Then to Oligodendrocyte Precursors
19
But do these cells have the potential to form
tumors over longer periods of time?
20
Embryonic Stem Cells
  • They can generate large quantities of tissue
    rapidly

Human Embryonic Stem Cells
2. They can become any cell in the body
Embryonic stem cells
Brain
Heart
Fat
Bone marrow
Cartilage
21
Developing facilities for stem cell research
  • It is likely that research involving non-approved
    stem cell lines will be prohibited in facilities
    that were built with NIH support, or that contain
    NIH-supported core equipment.
  • In recognition of this, up to 10 of Prop. 71
    funds will be used to build scientific and
    medical research facilities.
  • Funding through Prop. 71 for development of
    facilities requires a 20 match.

22
Proposition 71 Funds
  • Indirect costs limited to 25 of a research
    award
  • Excluding amounts included in a facilities
    award
  • Indirect cost limitation may be increased by
    amount the grantee provides in matching funds
  • Must be in excess of 20 of the grant amount
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