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Stem Cells Sweden

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Title: Stem Cells Sweden


1
Stem Cells Sweden
A key area for stem cell research and investment
2
A major new healthcare sector
  • Stem cell research with
  • potential to transform disease treatment, reduce
    costs to society, and enhance quality of life for
    millions of patients.
  • scope for significant business opportunities,
    with new directions for industry innovation and
    product development.
  • A unique combination of scientific know-how and
    commercialization capabilities is enabling Sweden
    to become a world force in the field.

3
Business opportunities in Sweden
  • Leading stem cell researchers and research
    institutes.
  • Global position in culturing embryonic stem cell
    lines.
  • Favorable political and ethical climate.
  • Relatively easy to capitalize on innovations
    teachers exemption and technology transfer
    units
  • Sophisticated and specialized domestic venture
    capital industry.

Sweden has emerged as a key area for stem cell
research and investment. Elliott Davis, General
Partner, Next Wave Funds
4
Current market potential
  • Licensing of stem cell lines.
  • Proliferation and characterization of specialized
    lines.
  • Commercialization of media that direct cell
    differentiation.
  • Diagnostic methods and techniques
  • Therapy development.

A number of Swedish companies have been founded
to capture business opportunities in stem cell
research.
5
Good reasons to choose Sweden for stem
cell-based RD
  • Source of breakthrough research achievements
  • Holds a large share of human embryonic stem cell
    lines eligible for U.S. public funding.
  • The legislative environment supports all areas of
    stem cell research.
  • Has more than 30 stem cell research groups and
    300 people at nine Swedish institutions involved.
  • Stem cell clusters are emerging at three
    prominent life sciences sites.
  • Capability to cover whole value chain for
    commercialization of stem cell research.

6
Stem cells a definition
  • Undifferentiated cells that give rise to all of
    the bodys cells and organs. Three sources of
    stem cells embryonic, adult and fetal. Research
    performed on humans and in animal models.
  • Capacity for self-renewal through repeated cell
    division, every stem cell can form two identical
    copies of itself
  •  … and multipotency stem cells can form progeny
    that can differentiate, i.e. develop into one of
    the different types of cells that comprise the
    living organism
  • In principle, each one of the human bodys 200
    different cell types can be cultured from a
    single immature stem cell.
  • Research performed on different tissue types
    Hematopoietic (blood) Neural (brain)
    Mesenchymal (connective tissue, muscles, blood
    vessels)

7
From stem cell to full-fledged body cell
8
Potential to cure a variety of diseases
  • Blood cells Cancer, immunodeficiencies, inherited
    blood, diseases, leukaemia
  • Bone cells Osteoporosis
  • Cartilage cells Osteoarthritis
  • Heart muscle cells Heart attacks, congestive
    heart failure
  • Insulin-producing cells Diabetes
  • Liver cells Hepatitis, cirrhosis
  • Nerve cells Stroke, Parkinsons disease,
    Alzheimers disease, spinal cord injury, multiple
    sclerosis
  • Retinal cells Macular degeneration
  • Skeletal muscle cells Muscular dystrophy
  • Skin cells Skin cells burns, wound healing
  • Two therapeutic approaches have been
    distinguished
  • Cellular therapy (i.e. cell transplantation)
  • Pharmaceutical approach (signaling substances)

9
High quality of research (1)
Source Boston Consulting Group, Swedish Brain
Power, 2001
10
High quality of research (2)
The graph shows individual countries share of
publications in scientific journals per capita.
Publications in 24 scientific journals were
studied and classified according to each
journals impact factor.
Source Boston Consulting Group, Swedish Brain
Power, 2001
11
Large commercial potential
  • High-potential diagnoses in stem cell research
  • Global economic burden for society (BUSD)

(1) Aggregate of CNS diagnoses included in
graph. (2) Based on osteoarthrosis costs. (3)
Assumes that liver failure costs are maximum of
1/3 of all gastroenterology costs.
Note Year 2000 market figures Source Boston
Consulting Group, Swedish Brain Power, 2001
12
Sweden possesses the required cross-functional
capabilities
(1) Includes e.g., hematologists, cardiologists,
transplant surgeons, orthopedics. Source Adapted
from Boston Consulting Group, Swedish Brain
Power, 2001
13
Breakthroughs by Swedish researchers
  • First clinical trials of fetal neural cell
    grafting in patients with Parkinsons disease
    (Anders Björklund and Olle Lindvall, 1987)
  • Discovered the nesting gene, the most commonly
    used marker for neural stem cells (Urban Lendahl,
    1990)
  • First to demonstrate that the human brain
    contains cells with stem cell-like properties
    (Peter Eriksson, 1998)
  • First to identify adult neural stem cells capable
    of forming new neural stem cells (Jonas Frisén et
    al, 1999)
  • First to identify adult stem cells potential to
    generate a variety of cells for other organs
    (Jonas Frisén et al, 2000)

14
Commercialization resources in Sweden
  • Basic research
  • Funding
  • Key competences
  • Key technologies
  • International and domestic networks with leading
    research groups
  • Positive bioethical and regulatory environment
  • Clinical development
  • Good animal disease models for proof-of-concept
  • High integration of basic and clinical research
  • Multidisciplinary groups of relevant specialists
    with co-location/closeness
  • Well-designed studies
  • Excellent conditions for clinical research
  • Commercialization
  • Venture capital and management skills
  • Technology transfer and spin-offs infrastructure
  • Cluster of companies biotech, med-tech,
    diagnostics, big pharma
  • Closeness including shared core facilities

Source Boston Consulting Group, Swedish Brain
Power, 2001
15
Major sites for stem cell research
  • Karolinska Institutet, Stockholm www.ki.se
  • Leading position in basic research on adult stem
    cells, especially in neurology area.
  • Very strong in developmental neurobiology and
    cellular biology.
  • Good IVF clinic and leading position in embryonic
    stem cell lines development.
  • Strong stem cell transplantation unit.
  • Strong developmental biology groups in CNS,
    pancreas and hematology.
  • Sahlgrenska Academy, Göteborg www.sahlgrenska.gu.
    se
  • Leading position in establishing embryonic cell
    lines.
  • Strong IVF program.
  • Leading position in research on adult
    neurogenesis and stem cell neurobiology.
  • Strong developmental biology groups in pancreas,
    blood vessel formation, and cellular biology.
  • Leading position in developing FDA approved,
    (GMP) certified cell-based transplantation
    therapy (cartilage repair).
  • Lund University, Lund www.lu.se
  • Leading position in clinical applications of cell
    therapy in neurology area.
  • Good stem cell biology in hematopoetic area and
    gene therapy vectors.

16
Examples of stem cell research projects (1)
  • Chalmers University of Technology, Göteborg
  • Julie Gold Methods to steer differentiation of
    stem cells at specific spatial locations using
    cell surface interactions.
  • Tomas Gustavsson Development of advanced image
    analysis systems to study cell division and
    differentiation.
  • Sahlgrenska Academy, Göteborg
  • Peter Eriksson Broad studies on the molecular
    mechanisms involved in neural stem cell
    proliferation and differentiation and their use
    in therapeutic strategies.
  • Lars Hamberger/Charles Hanson Improving culture
    methods for blastocyst development to secure
    optimized stem cell material for further
    identification and analysis.
  • Anders Lindahl Development, growth and
    regeneration of hyaline cartilage.
  • Henrik Semb Definition of optimal cultivation
    conditions for human embryonic stem cells and
    continuous generation of such lines.
  • University of Lund
  • Anders Björklund Neural stem cells and
    immortalization of neural stem cell lines.
    Development of cells for transplantation.
  • Sten Eirik Jacobsen Hematopoietic stem cells and
    molecular mechanisms governing stem cell
    differentiation.
  • Stefan Karlsson Research program studying the
    genetic control of hematopoietic stem cell
    proliferation.
  • Olle Lindvall Research program for
    transplantation of neural stem cells, for
    instance to regain function after Parkinsons
    disease and stroke.

17
Examples of stem cell research projects (2)
  • Karolinska Institutet, Stockholm
  • Ernest Arenas Identification and
    characterization of signals required to instruct
    and promote the survival of midbrain dopaminergic
    (DA) neurons.
  • Patrik Ernfors Neural crest stem cells and
    regulation of differentiation and functionality
    of peripheral sensory neurons.
  • Jonas Frisén Broad neurobiological research
    studying the physiological importance of nerve
    cell development and regulating mechanisms.
  • Outi Hovatta/Lars Ährlund-Richter Finding
    optimal cultivation conditions for human
    embryonic stem cells with particular regard for
    potential clinical applications.
  • Katarina Le Blanc Human mesenchymal studies of
    stem cells from bone marrow of adult individuals
    and from fetal livers.
  • Urban Lendahl Gene regulation in CNS stem cells,
    particularly in relation to the Notch signaling
    pathway.
  • Thomas Perlman How signals from nuclear
    receptors affect the development and survival of
    certain neural stem cell types.
  • Olle Ringdén Allogenic bone marrow or
    hematopoietic stem cell transplantation in the
    treatment of human blood disease, particularly
    leukemia.
  • University of Linköping
  • Per Fagerholm Effect of corneal stem cell
    transplantation to treat various forms of corneal
    damage. Strong clinical profile.

18
Examples of stem cell research projects (3)
  • University of Stockholm
  • Barbara Cannon/Jan Nedergaard Study of brown fat
    tissue, with particular regard to the regulatory
    functions of noradrenaline.
  • Anders Jakobsson Homologic recombination in
    embryonal mouse stem cells to produce mice with
    genetic mutations.
  • University of Umeå
  • Leif Carlsson Clarification of molecular
    mechanisms for immortalizing hematopoietic stem
    cells and development of systems for in-vitro
    cultivation of hematopoietic stem cells for
    clinical purposes.
  • Swedish University of Agricultural Sciences,
    Uppsala
  • Eva Hellmén Organogenesis of lymph nodes in
    relation to varying breast tumor phenotypes in
    differing species.
  • University of Uppsala
  • Michael Welsh The role of the endothelium in
    pancreatic beta cell differentiation.

Source Swedish Research Council, A Survey on
Stem Cell Research in Sweden, 2002
19
Favorable Swedish legislative climate Guidelines
for ethical review of human stem cell research
applications
  • Stem cells from adults YES
  • Stem cells from umbilical-cord blood after
    childbirth YES
  • Stem cells from aborted foetuses before week 14
    YES
  • Stem cells from embryos which remain after in
    vitro fertilization YES
  • Creation of embryos from eggs and sperm solely
    for research purposes NO
  • Somatic cell nuclear transfer (therapeutic
    cloning) YES

While many countries are hampered by the ethical
debate to limit embryonic research, Sweden has
supported the development of potential benefits
instead. Elliott B. Davis, Next Wave Funds
20
Making stem cell research a business
  • Cell Therapeutics Scandinavia, Göteborg ?
    therapies for human diseases and other
    applications of stem cell technologies.
  • Neuronova, Stockholm ? technologies to
    proliferate adult neural stem cells in culture
    and to differentiate them into dopaminergic
    neurons, for transplantation use w/ Parkinsons
    disease.
  • NsGene, Copenhagen (Stockholm/Lund) ? products to
    treat neurological diseases, based on cell and
    gene therapy
  • Vitrolife, Göteborg ? products for assisted
    reproduction and transplantation.

Target areas include neurodegenerative disorders,
degenerative joint diseases, cardiovascular
diseases, and diabetes.
21
ISA your business facilitator
  • Dedicated life sciences teams in the U.S, Europe
    and Asia.
  • For further information, please contact Lars
    Vedin M.D. Head of Life Bio Sciences Direct
    phone 46 8 402 78 33 Mobile phone 46 707 28
    73 90 lars.vedin_at_isa.se www.isa.se/lifesciences.
    htm
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