The National Marrow Donor Program: A resource for unrelated donor transplantation

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The National Marrow Donor Program A resource for
unrelated donor transplantation

• Dennis L. Confer, M.D.Chief Medical Officer,
  NMDP
• June 2, 2004

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Who is the NMDP?

• 501(c)(3) Non-profit corporation
• Headquartered in Minneapolis, Minn
• The worlds largest network facilitating
  unrelated donor transplants
• Since 1987, NMDP has held the federal contract to
  operate the National Bone Marrow Donor Registry

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NMDP Mission Statement

• Extend and improve life through innovative
  cellular transplant therapies

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Transplant Activity since 1987through May 31,
2004

• 18,927 Total Transplants Facilitated
• 14,917 Bone Marrow Transplants
• 3,679 PBSC Transplants
• 331 Cord Blood Transplants

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National Marrow Donor Program Adult Donors
CBUs April 30, 2004
Adult Donors
CBUs
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The NMDP Network
155 Transplant Centers(38 International)
89 Donor Centers(7 International)
9 Recruitment Groups
86 Apheresis Centers
Search Tracking and RegistrySTAR
104 Collection Centers(17 International)
13 Cord Blood Banks
Research Sample Repository
3 HLA TypingRepositories
22 HLA TypingLaboratories
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The NMDP Link Products
Transplant Centers TRANS Link
Donor Centers STAR Link
Search Tracking and RegistrySTAR
HLA TypingRepositories CRIS Link
Cord Blood Banks CORD Link
FORMS NetTM
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NMDP Infrastructure

• Office of Patient Advocacy
• Membership and Quality Systems
• Data submission requirements
• Adverse event reporting
• Public and professional education
• Search and transplant services

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Why Cord Blood?
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Matching Adult Donors for Patients over the
History of the NMDP
Percent of Patients with at least one HLA-A, -B
-DRB1 Potential Match
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Matching Adult Donors for Patients over the
History of the NMDP
Percent of Patients with at least one HLA-A, -B
-DRB1 Potential Match
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Matching Adult Donors for Patients By Number of
Donors
Percent of Patients with at least one HLA-A, -B
-DRB1 Potential Match
Number of HLA-A, -B and -DR Typed Donors
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Umbilical Cord Blood

• Major Advantage
• Less stringent HLA matching requirement
• Additional Advantages
• Ready availability
• Minimal donor risk

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NMDP Cord Blood Bank Network

• LifeCord, Gainesville
• Bonfils Cord Blood Services, Denver
• Ashley Ross Cord Blood Program, San Diego
• St. Louis Cord Blood Bank, St. Louis
• ITxM Cord Blood Services, Glenview
• Childrens Hospital of Orange County,
  Orange
• New Jersey Cord Blood Bank, Camden
• Puget Sound Blood Center/Northwest Tissue Center,
  Seattle
• ARC Western Area Community CBB, Portland
• StemCyte, Inc., Arcadia
• ARC North Central Blood Services, Cord Blood
  Program, St. Paul
• J.P. McCarthy Cord Stem Cell Bank, Detroit
• Carolinas Cord Blood Bank, Durham

13 Cord Blood Banks 30,874 Cord Blood Units are
currently listed 1,000 Transplants331 through
the NMDP
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NMDP Cord Blood Committee

• Membership includes
• Transplant physicians
• Cord blood bank directors
• Scientists
• Ethicists
• Obstetricians
• NMDP staff
• HRSA representatives
• Informal participation by FDA

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NMDP Cord Blood Committee

• Subcommittees address
• Quality standards
• Proficiency and quality systems
• Information technology
• Collections and outreach
• Bank/TC interface
• Economics and contracts
• Education and professional education
• Research and ethics

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TRANS Link displays all matches
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Summary

• NMDP is dedicated to serving the needs of
  patients
• Cord blood offers the potential to match many
  more patients and is expected to play a major
  role in the future of unrelated donor transplant
  therapies
• With federal support, the NMDP has developed,
  operates and continues to expand the worlds
  largest network for unrelated donor transplant
  therapies

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Summary, continued

• NMDP supports federal funding to expand our
  nations cord blood inventory
• Investment of public dollars requires
  accountability, efficiency and effectiveness to
  maximize the benefit to patients
• NMDP supports the IOM Committees efforts and is
  ready to provide information and assistance as
  needed