Metabolic Effects of Divalproex vs Olanzapine in Bipolar Disorder

1
Metabolic Effects of Divalproex vs Olanzapine in
Bipolar Disorder

• Treatment of Mania (N 120)

OLZ (N 57)
DVP (N 61)
Metabolic Parameter
P-Values
Total cholesterol (mg/dL) -1.69 13.29 0.019 LDL
(mg/dL) -4.43 8.78 0.022HDL (mg/dL) -0.93 -0.79
0.945 Glucose (mg/dL) 4.40 10.50 0.480 Weight
(lb) 5.50 8.80 0.049 Triglycerides
(mg/dL) 13.9 24.3 0.096 Total
protein (g/dL) -0.23 0.09 0.009 AST/ALT (IU/L)

NS
Mean change from baseline to final 84 DVP 2115
mg, OLZ 14.7 mg days, mean maximum daily drug
dosages Zajecka JM, et al. J Clin Psychiatry.
2002631148-1155.