PATTERN OF ADVERSE DRUG REACTIONS DUE TO CANCER CHEMOTHERAPY IN A TERTIARY CARE TEACHING HOSPITAL IN - PowerPoint PPT Presentation

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PATTERN OF ADVERSE DRUG REACTIONS DUE TO CANCER CHEMOTHERAPY IN A TERTIARY CARE TEACHING HOSPITAL IN

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1. Department of Radiotherapy and Oncology, Manipal Teaching Hospital, Pokhara, Nepal. ... Data regarding safety profile of cancer chemotherapy is lacking in Nepal ... – PowerPoint PPT presentation

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Title: PATTERN OF ADVERSE DRUG REACTIONS DUE TO CANCER CHEMOTHERAPY IN A TERTIARY CARE TEACHING HOSPITAL IN


1
PATTERN OF ADVERSE DRUG REACTIONS DUE TO CANCER
CHEMOTHERAPY IN A TERTIARY CARE TEACHING HOSPITAL
IN NEPAL
  • Authors S Mallik, 1 Subish P, 2, 3 Ojha P, 3
    Mishra P 2, 3
  • Presenting author
  • 1. Department of Radiotherapy and Oncology,
    Manipal Teaching Hospital, Pokhara, Nepal.
  • 2. Department of Pharmacology, Manipal Teaching
    Hospital / Manipal College of Medical Sciences,
    Pokhara , Nepal.
  • 3. Department of Hospital and Clinical Pharmacy,
    Manipal Teaching Hospital, Pokhara, Nepal.

2
Introduction
  • Definition of Adverse Drug Reaction (ADR) by WHO
    any response to a drug which is noxious,
    unintended and occurs at doses used in man for
    prophylaxis, diagnosis or therapy
  • Cancer chemotherapeutic drugs- several ADRs

3
Introduction cont..
  • ADRs increased health care cost, diminished
    quality of life, increased hospitalization and
    even death
  • Data regarding safety profile of cancer
    chemotherapy is lacking in Nepal
  • So this study was carried out

4
Objectives
  • To study the demographic details of the patients
    who had developed ADRs during chemotherapy
  • To study the pattern of ADRs occurring in the
    patients treated with chemotherapy in Manipal
    Teaching Hospital (MTH), Pokhara, Nepal
  • To identify the drugs used in managing ADRs and
    the duration of their use

5
Methodology
  • Study site Department of Radiotherapy and
    Oncology, MTH , Pokhara, Nepal
  • Study duration 6 months (1st January to 30th
    June 2006)
  • Study type Retrospective study
  • Inclusion criteria Patients who underwent
    chemotherapy and developed ADR was included

6
Methodology cont..
  • Operational modality
  • Patients were identified
  • Went through all patient file
  • All the necessary information was collected and
    were analysed

7
Results
  • Among 60 patients , 25 patients ( 41.67)
    developed ADR during the study period
  • Men60
  • Women 40

8
Age distribution (n25)
9
Diagnosis of the patients developing ADRs (n25)
10
Treatment type of the patients developing the
ADRs (n25)
11
Suspected drug category causing ADRs (n25)
12
Suspected drugs causing the ADRs (n25)
13
Duration of drug use of the suspected drugs
causing the ADRs (n25)
14
Duration of stay of the patients developing the
ADRs (n25)
15
Type of adverse drug reactions
16
Type of adverse drug reactions cont
17
Drugs used to manage the ADRs (n23)
18
Drugs used to manage the ADRs (n23) cont
19
Discussions
  • Males- maximum number of ADRs (could not identify
    the reason)
  • Elderly-majority of ADRs
  • Alkylating agents- more responsible ( Cisplatin
    44 , electrolyte imbalance)
  • Common ADR- hematological system
  • Increased dose of antiemetic and Levamisole were
    used to manage the ADRs

20
Conclusion
  • Male, 61-70 years at higher incidence
  • Mostly hematological system affected
  • Cisplatin most common to cause ADRs
  • Levamisole used in many cases to manage ADRs

21
Recommendation
  • Similar studies covering more patients from
    different regions are needed to extrapolate our
    results

22
Thank you
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