Title: PATTERN OF ADVERSE DRUG REACTIONS DUE TO CANCER CHEMOTHERAPY IN A TERTIARY CARE TEACHING HOSPITAL IN
1PATTERN OF ADVERSE DRUG REACTIONS DUE TO CANCER
CHEMOTHERAPY IN A TERTIARY CARE TEACHING HOSPITAL
IN NEPAL
- Authors S Mallik, 1 Subish P, 2, 3 Ojha P, 3
Mishra P 2, 3 - Presenting author
- 1. Department of Radiotherapy and Oncology,
Manipal Teaching Hospital, Pokhara, Nepal. - 2. Department of Pharmacology, Manipal Teaching
Hospital / Manipal College of Medical Sciences,
Pokhara , Nepal. - 3. Department of Hospital and Clinical Pharmacy,
Manipal Teaching Hospital, Pokhara, Nepal.
2Introduction
- Definition of Adverse Drug Reaction (ADR) by WHO
any response to a drug which is noxious,
unintended and occurs at doses used in man for
prophylaxis, diagnosis or therapy - Cancer chemotherapeutic drugs- several ADRs
3Introduction cont..
- ADRs increased health care cost, diminished
quality of life, increased hospitalization and
even death - Data regarding safety profile of cancer
chemotherapy is lacking in Nepal - So this study was carried out
4Objectives
- To study the demographic details of the patients
who had developed ADRs during chemotherapy - To study the pattern of ADRs occurring in the
patients treated with chemotherapy in Manipal
Teaching Hospital (MTH), Pokhara, Nepal - To identify the drugs used in managing ADRs and
the duration of their use
5Methodology
- Study site Department of Radiotherapy and
Oncology, MTH , Pokhara, Nepal - Study duration 6 months (1st January to 30th
June 2006) - Study type Retrospective study
- Inclusion criteria Patients who underwent
chemotherapy and developed ADR was included
6Methodology cont..
- Operational modality
- Patients were identified
- Went through all patient file
- All the necessary information was collected and
were analysed
7Results
- Among 60 patients , 25 patients ( 41.67)
developed ADR during the study period - Men60
- Women 40
8Age distribution (n25)
9Diagnosis of the patients developing ADRs (n25)
10Treatment type of the patients developing the
ADRs (n25)
11Suspected drug category causing ADRs (n25)
12Suspected drugs causing the ADRs (n25)
13Duration of drug use of the suspected drugs
causing the ADRs (n25)
14Duration of stay of the patients developing the
ADRs (n25)
15Type of adverse drug reactions
16Type of adverse drug reactions cont
17Drugs used to manage the ADRs (n23)
18Drugs used to manage the ADRs (n23) cont
19Discussions
- Males- maximum number of ADRs (could not identify
the reason) - Elderly-majority of ADRs
- Alkylating agents- more responsible ( Cisplatin
44 , electrolyte imbalance) - Common ADR- hematological system
- Increased dose of antiemetic and Levamisole were
used to manage the ADRs
20Conclusion
- Male, 61-70 years at higher incidence
- Mostly hematological system affected
- Cisplatin most common to cause ADRs
- Levamisole used in many cases to manage ADRs
21Recommendation
- Similar studies covering more patients from
different regions are needed to extrapolate our
results
22Thank you