The Ecology and Evolutionary History of an Emergent Disease: Hantavirus Pulmonary Syndrome

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The Ecology and Evolutionary History of an
Emergent Disease Hantavirus Pulmonary Syndrome

• Terry L. Yates
• Sevilleta Symposium
• 2003

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Relationship with Prototype Viruses
SEO SR-11 SEO R-22 SEO B-1 HTN Lee HTN 76-118 PUU
Paris PUU CG1820 PUU Sotkamo NEW
MEXICO ARIZONA COLORADO CALIFORNIA OREGON N.
DAKOTA MONTANA P.H.V. LOUISIANA
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Rattus norvegicus Microtus pennsylvanicus Peromysc
us maniculatus (grass) Peromyscus maniculatus
(forest) Peromyscus leucopus (NE) Peromyscus
leucopus (NW) Peromyscus leucopus
(SW) Reithrodontomys megalotis Reithrodontomys
mexicanus Sigmodon hispidus texensis Sigmodon
hispidus Sigmodon alstoni Oryzomys palustris
Oligoryzomys flavescens Oligoryzomys
chacoensis Oligoryzomys longicaudatus
(N) Oligoryzomys longicaudatus (S) Oligoryzomys
microtis Calomys laucha Akodon azarae Bolomys
obscurus
TREE OF LIFE
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Copemys (16 Mya)
20 Mya
Abelmoschomys (9 Mya)
?
?
Oryzomys?, Sigmodon?
7-9 Mya ?
?
Auliscomys (4.5 Mya)
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TREE OF LIFE
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Seoul Prospect Hill Sin Nombre Monongahela New
York Blue River (IN) Blue River (OK) El Moro
Canyon Rio Segundo Muleshoe Black Creek
Canal Caño Delgadito Bayou Lechiguanas Bermejo Or
an Andes Rio Mamore Laguna Negra
Pergamino Maciel
Rattus norvegicus Microtus pennsylvanicus Peromysc
us maniculatus (grass) Peromyscus maniculatus
(forest) Peromyscus leucopus (NE) Peromyscus
leucopus (NW) Peromyscus leucopus
(SW) Reithrodontomys megalotis Reithrodontomys
mexicanus Sigmodon hispidus texensis Sigmodon
hispidus Sigmodon alstoni Oryzomys palustris
Oligoryzomys flavescens Oligoryzomys
chacoensis Oligoryzomys longicaudatus
(N) Oligoryzomys longicaudatus (S) Oligoryzomys
microtis Calomys laucha Akodon azarae Bolomys
obscurus
Seoul Prospect Hill Sin Nombre Monongahela New
York Blue River (IN) Blue River (OK) El Moro
Canyon Rio Segundo Muleshoe Black Creek
Canal Caño Delgadito Bayou Lechiguanas Bermejo Or
an Andes Rio Mamore Laguna Negra Pergamino Maciel
Smith and Patton,1999
Plyusnim and Morzunov, 2001
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Trophic Cascade Hypothesis(TCH)

• Changes associated with El Niño alter weather
  patterns in U.S. Southwest
• Increased winter-spring precipitation leads to
  increases in vegetation and insect populations
• Increases in food and shelter increases
  size/density of rodent populations
• Increases in density alters the quantity/quality
  of SNV infection in Peromyscus populations
• Return of normal weather patterns leads to
  increased contact with humans

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Canyon del Muerto
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Carrying capacity (derived from landscape)
Typical desert landscape
Mice populations (result of model, given the
carrying capacity)
from Abramson Kenkre (2002)
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Ascertain Phylogenetic Relationships
Extract DNA
Determine DNA sequence
Blood or Tissue
Dragoo and Honeycutt, 1997