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Diagnosis of Aspergillosis by Antigen Detection

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Title: Diagnosis of Aspergillosis by Antigen Detection


1
Diagnosis of Aspergillosis by Antigen Detection
  • L. Joseph Wheat Chadi Hage
  • MiraVista Diagnostics
  • Indiana University Medical Center

2
Airborne Conidida Infectious
3
Angio-Invasive ?Dissemination
4
CT Findings
5
Halo Sign
6
Evolution of CT Findings
7
Air Crescent
8
Aspergillosis in Non-immunocompromised Host
  • Fungus Ball
  • Chronic Invasive

9
Difficulty in Diagnosis
10
Platelia Aspergillus EIA
  • Platelia EIA
  • Example

11
EDTA-Heat Pre-treatment
12
Dissociation Immune Complexes
EDTA
100 C
13
Need for EDTA-Heat Pretreatment
14
Bronchopulmonary Lavage
15
Analysis of Proven or ProbablePossible Excluded
16
Hematology
17
Bone Marrow Transplant
18
Hematology
19
Lung Transplant Surveillance
20
Solid Organ Transplant
21
GM Index inSolid Organ Transplant
22
Intensive Care Unit
23
Non-Immunocompromised
24
Summary Platelia BAL for Diagnosis of IPA
25
Experience in Clinical Testing
26
Causes for False Results
27
False-positive Aspergillus Antigenemia in
Histoplasmosis
28
False-Positive Platelia in Histoplasmosis
29
Sensitivity for Detection of Purified
Galactomannan
30
Consequence of False-Positive in Histoplasmosis
31
Diagnostic Approach in IPA
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