Structural Changes With BPD Progression: Episodes Are Associated With Brain Tissue Loss

1
Structural Changes With BPD ProgressionEpisodes
Are Associated With Brain Tissue Loss
Prefrontal Cortex ? Left inferior
prefrontal gray volumes with ? illness
duration ? Gray matter volume with ?
age Striatum No difference in putamen between
first- and multi-episode patients Cerebellum ?
Cerebellar vermis volume in multi- vs
first-episode patients Amygdala ? Amygdala volume
with ? age in young patients Ventricles ?
Ventricular volume in multi- vs first-episode
patients ? Ventricular volume with ? number of
manic episodes ? Ventricular volume with ? number
of affective episodes
Reviewed in Strakowski S, et al. Molecular
Psychiatry. 200510(1)105-116.