Research Capacity Building Programs of the Fogarty International Center, NIH International Affairs C

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Research Capacity Building Programs of the
Fogarty International Center, NIH
International Affairs CommitteeInfectious
Diseases Society of AmericaSan Juan, Puerto
RicoJune 21, 2002 Joel G. Breman, M.D.,
D.T.P.H.Senior Scientific AdvisorFogarty
International Center
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Fogarty International CenterScience for Global
Health
MissionTo promote and support research and
research training internationally to reduce
disparities in global health
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NIH International Research Expenditures
Fiscal Years 1994 to 2000
Dollars
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NIH Overall Expenditures on Tropical Infectious
Diseases
 
 
 
 
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Fogarty International CenterFunding for
Infectious Diseases Other Programs
Fiscal Year 2000 35 million
Other ProgramsFIRCABiodiversityInformaticsEnv
iron OccMCHCareer DevBioethicsOthers
AIDS 38
44
Emerging Inf Dis 5
Bioterrorism 1
Ecology Inf Dis 4
Malaria 2
TB 3
ABC/ICIDR 3

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Fogarty International CenterScience for Global
Health
Major Training and Research Sites
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Fogarty International CenterScience for Global
Health
Research Training Mechanisms

• Long-term training pre- and post-doctoral
  training in U.S. institutions (duration minimum
  9 months)
• Short-term training focused workshops and
  technology transfer (duration several days to
  several weeks)
• Research performed preferentially in-country

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Fogarty International CenterScience for Global
Health
Program Objectives

• Train leaders in science and public health
• Establish centers of excellence in home countries
• Promote long-term collaborations between U.S.
  and foreign institutions
• Facilitate outstanding scientific research
  focused on problems of developing countries
• Facilitate trainees assuming positions of
  responsibility, authority, and influence

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Fogarty International CenterScience for Global
Health
AITRP Accomplishments, Fiscal Years 1988-1998
FY88-93
FY94-98
Total
Long-term training epidemiology and
post-doctoral trainees countries
In-country activities courses trainees countries
654 59 264 16,624 30
1,02784 451 29,804 inc
1,681 98 715 46,428 65
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Fogarty International CenterScience for Global
Health
AITRP-Supported Achievements (examples)

• China Identified plasma donors at risk for HIV
• Kenya Uncircumcised males at risk for HIV 1 and
  genital ulcers
• Uganda Nevirapine injection to HIV-positive
  pregnant woman and neonates associated with 48
  decrease in perinatal transmission
• Uganda and Haiti Prophylaxis with INH and
  rifampin reduced TB and AIDS in HIV-positive
  persons

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Fogarty International CenterScience for Global
Health
AITRP-Supported Achievements (examples) 2

• Vietnam Subtype E (not Thai B) identified as
  main subtype among injection drug users and
  commercial sex workers
• Georgia Develop National AIDS Prevention Program
  and National Blood Safety Program

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International Clinical, Operational, and Health
Services Research Training Award for
AIDS/Tuberculosis (ICOHRTA - AIDS/TB)

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ICOHRTA - AIDS/TB
Emphasizes integration of therapy and care with
prevention efforts

Builds capacity to support the integration of
clinical, operational, and health services
research
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ICOHRTA - AIDS/TB
Fosters Major NIH International AIDS Research
Efforts

• Prevention Trials Network
• Vaccine Trials Network
• Comprehensive International Program of Research
  on AIDS (CIPRA)
• Popular Opinion Leaders
• International Centers for Excellence in Research
• Partnerships for HIV/AIDS Research in Africa

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ICOHRTA - AIDS/TB
Fosters Major USG and Other International AIDS
Research Efforts

• Elizabeth Glaser Pediatric AIDS Foundation
• Academic Alliance for AIDS Care and Prevention in
  Africa
• Global AIDS, TB, and Malaria Fund
• UNICEF, UNAIDS, and WHO AIDS and TB Programs

• CDC Global AIDS Program
• USAID Rapid Response (LIFE) Initiative
• Bill Melinda Gates Foundation
• amFAR

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Fogarty International CenterCountries in
Emerging Infectious Diseases Program, 2001
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ITREID Collaborations

• U.S. principal investigators 13
• Countries 36
• Americas 12
• Eastern Europe 10
• Asia 8
• Africa 6

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ITREID Accomplishments
2001, partial data new countries are
Bangladesh, Estonia, Rwanda, and Sri Lanka
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ITREID Accomplishments continued

• Scientific Output and Awards, FY 2000
• Science progress
• Presentations, 104
• Publications, 109 (submitted, accepted,
  published)
• Awards
• FIRCA award received by trainee from Czech
  Republic to work on C. parvum (NY State Dept of
  Health)
• Best poster European Society of Virology,
  molecular epidemiology of hepatitis C in
  Czechoslovakia (UC Berkeley)

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ITREID Pathogen Foci
Bacterial Diseases
Bartonella bacilliformis Corynebacterium
diphtheriae Leptospira Mycobacterium
tuberculosis, M. avium Streptococcus
pneumoniae STDs (chlamydia, gonococci)
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ITREID Pathogen Foci
Parasitic Diseases
Entamoeba histolytica Leishmania Plasmodium
falciparum, P. vivax Schistosoma
hematobium Trypanasomes
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ITREID Pathogen Foci
Viral and Rickettsial Diseases
Dengue Diarrhea and El Niño Human papilloma
virus Rickettsia prowazakii and R. felis
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Fogarty International CenterScience for Global
Health
Principles for Capacity Building and
Sustainability

• Long-term commitment National
  Institutional Trainee
• Re-entry grants for trainees
• Diversified program themes
• Mentoring and networking
• Dual appointments for faculty

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Global Health Research Initiative Program (GRIP)
Purpose Combat brain drain re-entry
grants Support the best science and the best
scientists to work on global health challenges
Eligibility Young scientists from resource-poor
nations completing NIH-supported training in
U.S. after returning home (NIH, academic
centers, D43 programs)
Support Level 50,000/year for up to 5 years for
salary and research costs
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Future and Focus of FIC Research Training
Programs

• In-country research, re-entry awards
• Organization of scientific workshops by trainees
• Promotion and tracking of trainees careers
• Special attention to
• Bioethics
• Good clinical practice involving human subjects

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Fogarty International CenterScience for Global
Health
Principles for Capacity Building and
Sustainability

• Long-term commitment National
  Institutional Trainee
• Re-entry grants for trainees
• Diversified program themes
• Mentoring and networking
• Dual appointments for faculty

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Fogarty International CenterScience for Global
Health
Principles for Capacity Building and
Sustainability (2)

• South-to-South collaboration
• Sustained linkages
• Contribution of resources from all partners
• Leverage resources for added support
• Connectivity via modern IT systems
• Centers of excellence in home countries
• Mutual benefits known to all

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FIC Website http//www.nih.gov/fic