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Sources of Funding for Academic Surgeon

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research in Cancer Prevention & Control. NIH Pathway to Independence Award K99/R00 ... Intent: Provide prostate cancer research training opportunities to individuals ... – PowerPoint PPT presentation

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Title: Sources of Funding for Academic Surgeon


1
  • Sources of Funding for Academic Surgeon
  • Career Development

James L. Mohler, M.D. Chair and Professor Gary
Smith, Ph.D. Distinguished Professor Department
of Urologic Oncology Prostate Cancer Research
Program Roswell Park Cancer Institute, Buffalo, NY
Leo Giambarresi, Ph.D. Program Manager Prostate
Cancer Research Program, CDMRP
2
POTENTIAL SOURCES OF FUNDING
  • National Institutes of Health (NIH)
  • Department of Defense (CDMRP)
  • Other PHS divisions CDC, AHRQ, NSF
  • VA
  • Foundations
  • Pharmaceutical companies

3
NIH OFFERS SOMETHING FOR EVERY CAREER LEVEL
4
Types of NIH Grant Awards
  • NIH Grants Office of Extramural Research
  • http//grants1.nih.gov/grants/oer.htm
  • Grant Mechanisms
  • National Research Service Awards (F_ T_)
  • Pre-and post-doctoral fellowships
  • Career Development Awards (K_)
  • Research Grant Programs (R_)
  • Small Business Development
  • SBIR (R41) Small Business Innovation Res
  • STTR (R43) Small Business Tech Transfer

5
National Research Service Awards (NRSA)
  • Established by the NRSA Act of 1974
  • Individual Fellowships (F31, F32, F33)
  • Institutional Training Grants (T32, T35)
  • Only NIH award that goes to an individual
  • 5 years support for grad/med students
  • 3 years support for post-doctoral fellows
  • Must be a U.S. citizen or permanent resident
  • Pay back provisions

6
NRSA Grant Application
  • Scholastic Performance
  • Research Experience / Training Plan
  • Personal Data Form
  • Biographical Sketch
  • Facilities and Commitment
  • Criteria for evaluation
  • candidate
  • training plan
  • success of training program

7
Individual NRSA Grants
  • F31 Ruth L. Kirschstein National Research
    Service Award Predoctoral Fellowship
  • support for research training leading to a Ph.D.
    (or the equivalent research degree) or a combined
    M.D./Ph.D. (or other combined professional
    research doctoral degrees) in the biomedical or
    behavioral sciences
  • F32 Ruth L. Kirschstein National Research
    Service Award Postdoctoral Fellowship
  • support for postdoctoral research training to
    individuals to broaden their scientific
    background and extend their potential for
    research in specified health related areas

8
Institutional NRSA Grants
  • T32 NRSA Institutional Training Grants
  • support training opportunities at the predoctoral
    or postdoctoral level at qualified institutions
  • Program Director is responsible for selecting the
    trainees and administering the program
  • T36 - Minority Access to Research Careers (MARC)
  • support to increase the number of well-trained
    minority scientists in biomedical disciplines and
    strengthen the research and teaching capabilities
    of minority institutions

9
NIH Career Development Programs
  • Purposes include to provide
  • mentored development of research careers
  • transitions of career emphasis
  • protected time for research by clinicians
  • support for outstanding scientists with a
    sustained level of high productivity
  • 13 different mechanisms
  • Match with the stage of career
  • Mentored, Mid-career, Senior
  • Can be interactive with other NIH Awards
  • Different availabilities/eligibilities at each
    institute

10
Mentored Research Grants
  • K01 Mentored Research Scientist Development
    Award
  • provide research scientists with a sponsored
    research experience that will help the applicant
    gain expertise in a new research area or
    demonstrably enhance the applicants scientific
    career
  • Replaced July 2, 2006 by the NIH Pathway to
    Independence
  • K22 Career Transition Award
  • support newly trained investigators (basic or
    clinical) to develop their independent research
    skills through a two phase program.
  • initial period involves an intramural appointment
    at the NIH
  • final period of support is conducted at an
    extramural institution.
  • research in Cancer Prevention Control

11
NIH Pathway to Independence Award K99/R00
  • Postdoctoral scientists receive both mentored
    independent research support from the same award
  • 1-2 year mentored phase (K99)
  • independent phase, occurs in years 3-5 (R00)
  • Goal to facilitate awardee
  • secure an assistant professorship (or equivalent)
  • establish an independent research program
  • apply for an investigator-initiated grant

12
Consider the review criteria
  • The candidate your background and potential to
    develop into an independent researcher
  • Research plan its scientific merit,
    significance, feasibility relationship to your
    career plans
  • Training/career development plan its components
    how well it fits the research plan
  • The sponsor his/her track record as both a
    researcher and mentor
  • Institutional environment commitment to the
    training/career development of the candidate

13
Identifying a Sponsor/Mentor
  • With a track record of successful training and
    research
  • With a commitment to you your career goals
  • He/she need not be your research advisor
  • More than one is OK!
  • Should have

14
Institutional Commitment
  • To your time
  • To your professional development
  • To your research efforts
  • Protected time
  • Protected time
  • Protected time
  • Protected time

15
Mentored Clinical Grants
  • K08 Mentored Clinical Scientist Development
    Award
  • Support the development of outstanding clinical
    research scientists
  • Provide specialized study for clinically trained
    professionals who are committed to a career in
    research and have the potential to develop into
    independent research scientists
  • K12 Mentored Clinical Scientist Development
    Program Award
  • Support newly trained clinicians appointed by an
    institution for development of independent
    research skills and experience in a fundamental
    science within the framework of an
    interdisciplinary research and development
    program.
  • K23 Mentored Patient-Oriented Research Career
    Development Award
  • support for the career development of
    investigators who focus their research endeavors
    on patient-oriented research
  • provides support for a period of supervised study
    and research for clinically trained professionals

16
Other Award Mechanisms
  • R15 Academic Research Enhancement Award (AREA)
  • support small-scale research projects conducted
    by faculty in domestic institutions that
    primarily award baccalaureate degrees
  • S06 Minority Biomedical Research Support (MBRS)
  • provide funds to strengthen the biomedical
    research and research training capability of
    ethnic minority institutions, thus creating a
    more favorable environment for increasing the
    involvement of minority faculty and students in
    biomedical research
  • K07 Academic Career Award
  • support
  • junior candidates who are interested in
    developing academic and research expertise in a
    specific area
  • senior individuals with acknowledged scientific
    expertise and leadership skills who are
    interested in improving the curricula and
    enhancing research capability within an academic
    institution

17
Career Development Transition from Post-Doc to
Faculty
  • K99/R00 Pathway to Independence
  • K08 M.D. proposing basic research in a
    laboratory environment
  • K12 M.D. proposing basic research in an
    interdisciplinary environment
  • K23 M.D. proposing clinical research
  • K24 Mid-career mentor for physician scientists

18
More Funding Information
  • You can sign on to list serves
  • NIH Funding http//nih.gov/grants/oer.htm
  • DOD Funding http//cdmrp.army.mil/

19
Award Mechanisms From Traineeships to
Established Independent Investigator Awards
Training
Early Career Established
Pre- Doctoral
New Investigator
Postdoctoral PhD
Idea Development
Postdoctoral MD
CAREER DEVELOPMENT
Physician Research

Synergistic Idea Development
Clinical Trial
Laboratory-Clinical Transition Stage I
20
Example Prostate Cancer Training Award
  • Intent Provide prostate cancer research training
    opportunities to individuals in the early stages
    of their careers
  • Key Features
  • Supports Ph.D. or M.D. predoctoral and
    postdoctoral trainees
  • Emphasis on Trainee, Mentor and Training Program
  • Peer Review Criteria Written for both Ph.D. and
    M.D. applicants
  • Funding Summary

21
Physician Research Training Award
  • Intent Recruit and prepare physicians for
    careers in research through a mentored training
    experience
  • Key award features
  • Requires 3-5 y commitment
  • Mentor must have an established research program
    in cancer research
  • Minimum 50 effort
  • 130K direct costs per year for 3-5 years
  • Eligibility
  • Physicians in the last year of graduate medical
    education or fellowship, or within 3 years of
    appointment as an Assistant Professor or
    equivalent

22
New Investigator Awards
  • Intent To support innovative ideas and new
    technologies from investigators in the early
    stages of their careers
  • Key Award Features
  • Innovation critical
  • Preliminary data not required
  • Must enlist collaborator(s) with relevant
    experience
  • Eligibility
  • Independent investigator with access to research
    facilities
  • Must be within 6 years of fellowship or
    postdoctoral position
  • Must not have received non-mentored extramural
    research funding 100K (direct) in aggregate
  • Funding 225K direct costs for 3 years

23
Idea Development Awards
  • Intent To encourage innovative approaches to
    prostate cancer research from established
    investigators in prostate cancer and those from
    other fields who want to move into prostate
    cancer
  • Key Award Features
  • Innovation critical
  • Preliminary data relevant to prostate cancer
    required
  • Eligibility
  • Independent investigator with access to research
    facilities
  • Must be Assistant Professor (or equivalent)
  • Funding 375K direct over 3 years

24
Clinical Trial Awards
  • Intent Support rapid initiation and efficient
    execution of novel Phase I, II or I/II clinical
    trials
  • Key award features
  • Focus should be on new interventions
  • Preclinical efficacy must be established already
  • A study coordinator is required
  • IND or IDE application must be submitted before
    the proposal receipt date
  • Eligibility
  • Independent investigator with access to research
    facilities
  • Must be at or above the level of Assistant
    Professor (or equivalent)
  • Funding 750K direct costs over 3 years

25
DoD-Supported Career Development Sequence
  • Physician Research Award or Postdoc Award
  • New Investigator Award
  • Idea Development Award or Clinical Trial Award
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