The Department of Defense Center for Deployment Health Research CDR Margaret Ryan, MC, USN Director

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The Department of Defense Center for Deployment
Health Research CDR Margaret Ryan, MC,
USNDirectorOverview for the Armed Forces
Epidemiological BoardSan Diego, 19 February 2002
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DoD Center Research Program

• Deployment Epidemiology
• Emerging Infectious Disease Research
• 68 research staff

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The Legacy of the Gulf War
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Original Gulf War Studies
Symptoms
Hospitalizations
Reproductive Health
Under leadership of CAPT Greg Gray, MC, USN (ret)
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Gulf War Veteran Epidemiological Studies
Accomplishments

• GW Hospitalization study (N Eng J Med, 1996)
• GW and birth defects (N Eng J Med, 1997)
• Goldenhar syndrome (Teratology, 1997)
• GW Registry study (Am J Epidemiol, 1998)
• Testicular cancer (Epidemiol, 1998)
• M. fermentans study (Am J Trop Med, 1999)
• Seabee study (Am J Trop Med, 1999)
• Khamisiyah exposure study (Am J Epidemiol, 1999)
• Mental health hospitalizations (Clin Epidemiol,
  1999)
• Nonfederal hospitalization study (Am J Epidemiol,
  2000)
• Factor analysis (Am J Epidemiol, 2000)
• PB and Gulf War veterans (Mil Med, 2000)
• SLE, ALS, and fibromyalgia (Am J Epidemiol, 2000)
• GW vets and birth defects, Hawaii (Teratology,
  2000)
• Oil well smoke (Am J Epidemiol, 2002)
• Seabee symptoms (Am J Epidemiol, 2002)

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DoD Deployment Health Research Center Projects
FY02

• DoD and VA Health GW Registry studies
• Health experience of Saudi Arabian National Guard
  after the GW
• Deployments to Southwest Asia, Bosnia, and Gulf
  War, Bosnia
• Anthrax vaccine and health outcomes
• Ciprofloxacin use after bioterrorism threats in
  2001
• Enlistment risk factors for dysfunctional
  families and careers
• Tobacco use in new recruits
• Epidemiology of STDs and abnormal cervical
  screening in recruits
• Epidemiology of asthma in active duty military
• Epidemiology of H. pylori infections in military
  families
• Survey study of immunization knowledge,
  attitudes, and beliefs
• Survey study of complementary alternative
  medicine use

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Clinical Trials Center

• VA / DoD Cooperative Study 475 - Antibiotic
  Treatment of Gulf War Veteran Illnesses - double
  blind, placebo-controlled study.
• VA / DoD Cooperative Study 470 - Exercise,
  Cognitive Therapy Trial - controlled evaluation
  of multiple modalities to reduce symptoms.
• A controlled trial of the effects of combination
  therapy with DEET, PB, and Permethrin on symptoms
  and neurocognitive function.
• An assessment of potential relationship between
  obesity and past adenovirus infections.

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DoD Deployment Health Research Center Projects
FY02 and Beyond

• Recruit Assessment Program
• DoD Birth and Infant Health Registry
• The Millennium Cohort Study

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Navy Hub for DoD Global Emerging Infection
Surveillance (GEIS)

• DoD-unique capabilities for diagnosis of
  militarily important respiratory pathogens
• Influenza A B
• Adenovirus
• Mycoplasma pneumoniae
• Chlamydia pneumoniae
• Streptococcus pyogenes
• Streptococcus pneumoniae
• Bordetella pertussis

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NHRC Respiratory Disease Surveillance Sites
Madigan Army MC
Great Lakes
Cape May
Bethesda
Ft Leonard Wood
WRAIR
Ft Knox
Portsmouth
Ft Sill
Ft Bragg
NMC San Diego
Ft Jackson
MCRD San Diego
MCRD Parris Island
BUDS
Ft Benning
Wilford Hall
Viral pathogens
S. pyogenes
S. pneumoniae
Pneumo vaccine
Ensenada, Mexico HMS Raliegh, United Kingdom
Pertussis
RSV
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Global Emerging Infection Surveillance
Accomplishments of the Gregory C. Gray Laboratory

• Mycoplasma pneumoniae (Mil Med, 1997)
• Bordetella pertussis (Clin Infect Dis, 1997)
• Azithromycin trial (Clin Infect Dis, 1998)
• DoD respiratory threats (Emerg Infect Dis, 1999)
• Ft Jackson outbreak (Emerg Infect Dis, 1999)
• Navy Respiratory Disease Laboratory (Mil Med,
  2000)
• Adenovirus orphaned vaccine (Clin Infect Dis
  2001)
• USS Arkansas flu outbreak (Emerg Infect Dis 2001)
• Pertussis PCR (Mol Cell Probes 2001)
• Adenovirus DNA testing (J Med Micro 2001)
• USNA study (Mil Med 2001)
• BUDS study (Clin Infect Dis 2001)
• Pneumococcal vaccine study (Mil Med 2001)
• Pneumococcal surveillance (JID 2001)
• Handwashing and resp illness (Am J Prev Med,
  2001)
• Adenovirus serotyping (J Clin Micro 2001)
• Adenovirus deaths (MMWR 2001)
• Adenovirus 73 outbreak (Clin Infect Dis 2002)

• CAP Certification (since 1999)
• WHO Collaborating Center - pending

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DoD Center for Deployment Health Research at the
Naval Health Research Center
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DoD Center for Deployment Health Research
http//www.nhrc.navy.mil/rsch/code25/program5.htm