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Integrated Blood Glucose Monitor and Insulin Dosage Device

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A disease in which the body either does not produce or effectively process the hormone insulin ... Audio Output 30-90 decibel capability. Memory Storage 16 MB ... – PowerPoint PPT presentation

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Title: Integrated Blood Glucose Monitor and Insulin Dosage Device


1
Integrated Blood Glucose Monitor and Insulin
Dosage Device
  • Group 22
  • Members Elizabeth Ochoa
  • Nicole Wilson
  • Jennifer Yu
  • Mentor Dr. Garry Tobin
  • Associate Professor
  • Washington University School of Medicine
  • BME 401 Engineering Design
  • September 24, 2007

2
Introduction Diabetes Mellitus
  • A disease in which the body either does not
    produce or effectively process the hormone
    insulin
  • Crucial in the metabolism of sugars, starches,
    and other foods
  • Required for the uptake of glucose into cells
  • Incurable but treatable chronic condition
  • "Equal Opportunity" disease

3
Introduction Prevalence of Diabetes in the
United States
14.6 million 6.2 million 20.8 million
Diagnosed Undiagnosed Total
7 of the American population
Source Centers for Disease Control and
Prevention, Fact Sheet 2
4
Introduction Prevalence of Diabetes in the
United States
Source Centers for Disease Control and
Prevention, Fact Sheet 2
5
Complications of Diabetes
  • Heart Disease and Stroke
  • Diabetic Retinopathy
  • High Blood Pressure
  • Diabetic Neuropathy
  • Kidney Disease
  • Complications of Pregnancy
  • Diabetic Ketoacidosis

Source Centers for Disease Control and
Prevention, Fact Sheet 2
6
Project Need
  • Preventing many complications associated with
    diabetes
  • Overcoming barriers to self-monitoring of blood
    glucose
  • Insurance coverage3
  • Lack of patient education4
  • Socioeconomic background5
  • Usability/Convenience
  • Motivation
  • Pain/Frustration5

7
Project Goals
  • To increase the efficacy of patient
    self-monitoring
  • To improve patient/doctor communication

8
Project Scope
  • Develop a blood glucose monitoring system with
    the capacity to store crucial long-term data
  • Eliminate the problem of mentally calculating and
    manually adjusting insulin dosage
  • Target populations elderly, non-native English
    speakers, recently diagnosed patients

9
Existing Solutions
  • Blood Glucose Monitors
  • Insulin Pumps

10
Blood Glucose Monitors
  • Accu-Chek Compact Plus
  • OneTouch UltraSmart

11
Overview of Blood Glucose Monitoring
  • Necessary Components
  • Lancets
  • Blood Glucose Test Strips
  • Blood Glucose Monitor
  • Logbook
  • Carbohydrate Intake/Insulin Dosage Comparison
    Chart
  • Insulin Dosage Device

12
Accu-Chek Compact Plus
  • Advantages
  • Preloaded Test Strip Drum
  • Detachable Lancet Device
  • Alternate Site Testing
  • 300 value memory with time and date
  • Disadvantages
  • Difficult to distinguish between buttons
  • Confusing Settings

Source www.accu-chek.com 6
13
OneTouch UltraSmart
  • Advantages
  • Requires only 1.0 µL of blood
  • Rapid test results
  • Able to track exercise, medication, health and
    food trends
  • Disadvantages
  • Overwhelming number of functions
  • Difficult to load test strips
  • Small text

Source www.onetouch.ca 7
14
Insulin PumpsMedtronic MiniMed Paradigm
  • Advantages
  • Eliminates multiple daily insulin injections
  • Uses rapid-acting insulin to maintain a basal
    level and to supply a bolus
  • More discreet
  • Disadvantages
  • Finger-stick glucose level measurements still
    necessary
  • Inexact reservoir gauge
  • High cost

Source www.minimed.com 9
15
Problems with Current Technology
  • Intimidating
  • Cost-efficiency vs. convenience
  • No all-inclusive model for blood glucose monitors
  • Portability

16
Design Specifications
  • Functions
  • Measure blood glucose levels
  • User-input foods to be consumed
  • Output insulin dosage
  • Long-term storage of input/output data
  • Downloadable data
  • Cost lt50

17
Design Specifications
  • Components
  • Lancet with adjustable penetration depth
    28-gauge10,11
  • Blood Glucose Test Strips12
  • LED Screen High contrast, 2.5 cm or larger
    displayed numbers
  • Audio Output 30-90 decibel capability
  • Memory Storage 16 MB
  • Battery Backup Lithium Button Cell and AAA
  • Button Controls Soft plastic, 4 mm raised above
    surface, 6 mm separation
  • Insulin Dosage Device 3 mL insulin storage

18
Preliminary Analyses
  • Measurement of Blood Glucose13,14
  • Memory Space
  • Calculation of HbA1c

A absorbance e absorption coefficient b
path length c concentration V voltage I
current R resistance
Beers Law
19
Project Schedule
20
Team Organization
  • Beth Final Presentation Hardware
    Integration Software Compatibility User
    Manual
  • Jennifer Preliminary Presentation Nutrition
    Research Patient Questionnaire IP Research
  • Nicky Progress Presentation Data
    Exporting CAD Drawings Website

21
References
  • National Diabetes Information Clearinghouse.
    National Institute of Diabetes and Digestive and
    Kidney Diseases, National Institutes of Health.
    http//www.diabetes.niddk.nih.gov/
  • Centers for Disease Control and Prevention.
    National diabetes fact sheet general information
    and national estimates on diabetes in the United
    States, 2005. Atlanta, GA U.S. Department of
    Health and Human Services, Centers for Disease
    Control and Prevention, 2005.
  • Bowker, S. L, et. al., Lack of insurance
    coverage for testing supplies is associated with
    poorer glycemic control in patients with type 2
    diabetes. CMAJ. 2004 July 6 171(1) 3943.
  • Fertig, B.J., et. al. Therapy for Diabetes.
    National Institute of Diabetes and Digestive and
    Kidney Diseases, National Institutes of Health.
    http//diabetes.niddk.nih.gov/dm/pubs/america/pdf/
    chapter25.pdf
  • Zgibor JC, Simmons D. Barriers to blood glucose
    monitoring in a multiethnic community. Diabetes
    Care. 2002 Oct25(10)1772-7.
  • Accu-Chek Compact Plus. www.accu-chek.com
  • OneTouch UltraSmart . www.onetouch.ca
  • DexCom STS. www.dexcom.com
  • Medtronic. www.minimed.com
  • Schraga Steven. Lancet having adjustable
    penetration depth. U.S. Patent 6156051.
    November 1999.
  • Taylor William C. Lancing device causing
    reduced pain. U.S. Patent 6045567. February
    1999.
  • McAleer Jerome F., et. al. Disposable test
    strips with integrated reagent/blood separation
    layer. U.S. Patent 6241862. June 2001.
  • Davies Oliver W.H., et. al. Measurement of
    substances in liquids. U.S. Patent 6733655.
    March 2000.
  • U.S. Food and Drug Administration. Center for
    Devices and Radiological Health. Review
    Criteria Assessment of Portable Blood Glucose
    Monitoring In Vitro Diagnostic Devices Using
    Glucose Oxidase, Dehydrogenase or Hexokinase
    Methodology. http//www.fda.gov/cdrh/ode/gluc.htm
    l
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