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Anterior Pituitary

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Know the clinically available drugs related to the hypothalamic and anterior ... Be able to recognize the role of peptide modifications at the termini of TRH. ... – PowerPoint PPT presentation

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Title: Anterior Pituitary


1
Anterior Pituitary
  • Lindsey.elmore_at_ucsf.edu

2
Be able to match each hypothalamic hormone with
the anterior pituitary hormone it regulates and
tell whether the action of the regulator is
stimulatory or inhibitory.
3
Know the clinically available drugs related to
the hypothalamic and anterior pituitary and their
possible uses.
  • Somatostatin anti-growth hormone
  • Octreotide used to treat acromegalia
  • Protirelin Thyrotropin releasing hormone (useful
    for diagnostic purposes)
  • Leuprolide and other congeners treats prostate
    CA and endometriosis
  • Somatropin Recombinant GH
  • Sermorelin GHRH
  • Mecasermin IGF-1
  • Bromocriptine, pergolide, and cabergoline PRL
    release inhibitors
  • Cosyntropin ACTH

4
When you study focus on somatostatin, TRH, and
GnRH
5
Octreotide
  • There are 5 receptor subtypes for somatostatin
    and there are drugs in development for each of
    the receptors.
  • Used to treat acromegalia by inhibiting GH release

6
Be able to recognize the role of peptide
modifications at the termini of TRH.
  • Lactam and amide on the end of molecule protects
    it from degradation.

7
For GnRH, know the function and modifications
used to provide more potent agonists.
8
Prolactin Release Inhibitors
  • Used to treat hyperprolactinemia which may lead
    to hypogonadism. Treats conditions where
    lactation needs to be inhibited.

9
Describe the POMC family.
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