Supersensitive magnetocardiographic system for early recognition, precise diagnostics and monitoring of heart diseases

1
Supersensitive magnetocardiographic system for
early recognition, precise diagnostics and
monitoring of heart diseases

• 12.10.2006
• Kiev
•  
• Dr.Volodymyr Sosnytskyy
• 38(044)5013072
• sosna_at_uninet.kiev.ua
• Kiev Medical Group, Ltd.
• Kiev

2
Proprietary information statement

• The technology material presented in this talk is
  available for licensing or joint product
  development.
• None of the slides contain any confidential or
  proprietary information which would prevent
  patenting the technology.

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Problem Description Market Need

• - Ischemic heart disease is the leading cause
  of death in Western countries.
• The early noninvasive diagnosis of ischemia is
  one of the major clinical problems that could
  benefit from the additional information provided
  by MCG.
• MCG can identify propensity to ventricular
  arrhythmias, in heart diseases , independently of
  other clinical variables.
• Contactless MCG can be ideal for research and
  development of new drugs and for experimental
  evaluation of gene therapy.
• The vicious circle lack of clinical equipment
  -gt clinician skepticism ( lack of experience) -gt
  lack of evidence-based clinical benefit -gt no
  real market -gt lack of investment -gt lack of
  development of clinical equipment.

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Brief technology description

• MCG is the measurement of magnetic fields emitted
  by the human heart from small currents by
  electrically active cells of the heart muscle.
• MCG is a completely noninvasive method that
  permits the registration of cardiac electrical
  activity at multiple site in a plane above the
  chest cage without the need for electrodes.
• MCG is both a method to record cardiac signals
  and to provide 3D functional imaging of cardiac
  electrophysiology.

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Averaged MCG 36-channels
Normal MCG
Map of magnetic field distribution on Tapex
Map of current density distribution on Tapex
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Advantages

• MCG is modern imaging and quantitative analysis
  technique for detection abnormal difference in
  electrophysiological cardiac phenomena
• Magnetocardiography (MCG) is a noninvasive and
  risk-free technique for contactless surface
  mapping of the magnetic fields generated by the
  electrical activity of the heart.
• This SQUID-based MCG system has a high potential
  for health care, especially because it could be
  used in hospital environments without expensive
  and inflexible magnetic shielded rooms.
• Recent availability of budget-price multichannel
  minisystems for unshielded MCG.
• MCG has been accepted as a clinical tool.

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Experimental results

• MCG Animal Studies
• PHANTOM AND SOURCE MODELING

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Clinical Trials (CAD with normal ECG vs.
Controls)
Sensitivity Specificity of MCG in CAD with
normal ECG
PET
- 90 - - 80 - - 70 - - 60 - - 50 - - 40 - - 30
- - 20 - - 10 -
PET
MCG 84.6
MCG 90.5
Stress Scintigraphy
Stress-EchoCG
Stress-EchoCG
Stress Scintigraphy
Exercise-ECG
Sensitivity
Specificity
Exercise-ECG
Holter monitoring
Holter monitoring
ECG at rest
ECG at rest
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Stage of development

• System is ready for application
• Clinical Trials detection of myocardial
  ischemia and arrhythmogenic risk assessment

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Targeted Market Segment

• MCG can be used for noninvasive diagnosis of
  cardiac events related to
• - coronary artery disease (CAD),
• - safety of all medical drugs with respect
  to the drugs potential to cause heart
  arrhythmia,
• - early detection of graft rejection
  after cardiac transplantation,
• - pathophysiological role and therapeutic
  potential of stem cells .
• Introduction of MCG diagnostics into routine
  clinical practice can improve patient outcomes,
  decrease mortality and risks, increase comfort
  and significantly reduce cost of health care.
• The cost of commercially available
  few-channel systems for unshielded MCG range
  between 200,000 and 500,000 US

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Competition

• More expensive or invasive methods
• - Stress-echocardiography,
• - Single photon emission computed tomography
  
• (SPECT)
• - Coronary angiography
• The cost of the equipment for MCG differs
  widely as function of approach prefered.
• Small unshielded systems can now be operated
  by nurses or research technicians

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Competitive Matrix
Important product or technology characteristics Kiev Medical Group, Ltd. Cardio Mag Imaging Inc. Cryoton Co.Ltd
Cost-effectiveness ------------------------- automated high complitely low semi middle semi
The evaporation rate L/day 1,7 2,5 2 - 3
Solution of the Inverse problem (Software) modern old modern
Costs ( X 1000 ) 200-300 gt 300-500 gt 300
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Opportunities

• We look forward on international collaboration
  for
• clinical trials
• joint product development

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Contact information

• Dr.Volodymyr Sosnytskyy
• 38(044)5013072
• sosna_at_uninet.kiev.ua
• Kiev Medical Group, Ltd.
• Kiev