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iGEM

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Can simple biological systems be built from standard, ... International Genetically Engineered Machine Competition ... powder, Ampicillin salt, ... – PowerPoint PPT presentation

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Title: iGEM


1
iGEM Synthetic Biology International
Genetically Engineered Machine Competition
SB 3.0 Zurich 6/24/07
  • Randy Rettberg
  • igem2007.com
  • parts.mit.edu

2
An Engineering Question
Can simple biological systems be built from
standard, interchangable parts and operated in
living cells? Or, is biology so complex that each
case is unique?
3
Education Driving Research
4
International Genetically Engineered Machine
Competition 2005
  • 13 Schools
  • Caltech MIT UC Berkeley
  • Cambridge, UK Oklahoma UCSF
  • Davidson Penn State UT Austin
  • ETH, Zurich Princeton
  • Harvard Toronto, Canada
  • Sponsored by Microsoft/MIT iCampus

5
iGEM 2006
  • 40 Schools, 33 Teams
  • 450 participants
  • Europe, Canada, Asia, Latin America, US
  • Some EU funding in place
  • iGEM ambassadors for US, Asia, and Europe
  • Jamboree November 4 5
  • www.iGEM2006.com
  • Supported by Microsoft Research and iCampus

6
iGEM 2006
Ege University, Turkey
7
www.iGEM2006.com
8
Meet the Teams
9
Valencia iGEM Site
10
iGEM 2006 Results
11
Sample iGEM Projects
  • Berkeley Controlled Communications
  • Davidson Flipping DNA
  • Harvard DNA Boxes
  • ETH Zurich Pattern Matching
  • Ljubljana Controlling Sepsis
  • Chiba Japan Light-Directed Chemotaxis
  • Mississippi Hydrogen Gas Detector
  • MIT Banana and Wintergreen Smells
  • Edinburgh Arsenic Detector

12
MIT iGEM 2006
eau de coli mit igem 2006
13
The field test device
  • A test tube could contain all the necessary
  • components Freeze dried bacteria, growth
    medium,
  • indicator powder, Ampicillin salt, etc…
  • These tubes could then be given to local
    villagers to monitor their own water quality
    themselves
  • A good alternative to the widely used Gutzeit
    method

www.Macteria.co.uk
14
Some Engineering Answers
Can simple biological systems be built from
standard, interchangable parts and operated in
living cells? - YES, SOMETIMES Or, is biology so
complex that each case is unique? - NOT ALWAYS
15
www.igem2007.com
16
Financial Resources
  • Small Sample
  • 20K 8
  • 30K 8
  • 40K 1
  • 50K 4
  • gt50K 2

17
iGEM 2007 and Beyond
  • 2008 100 Schools -gt Partition?
  • Geographic Competitions
  • Tracts
  • Health and Medicine
  • Energy and the Environment
  • Parts and Devices
  • Fun and Games
  • Sensors
  • Other

18
The Impact of iGEM
  • Students
  • Making future synthetic biologists
  • Teaching graceful competition
  • Instructors
  • Opportunities for junior faculty
  • New programs - new ideas
  • A task worth the effort
  • Schools
  • Synthetic biology entering curriculum
  • Energize research programs
  • Synthetic Biology
  • Examples, parts, successes, testamonials

19
Registry of Standard Biological Parts
An industry based on standard parts requires
catalogues and suppliers of those parts.
20
Registry Parts Catalog
http//parts.mit.edu
21
Registry Contents 7/2007
1400 Parts Available as DNA
  • Promoters
  • Protein Coding
  • Reporters
  • RNA
  • Terminators
  • Signaling
  • Many project parts

22
Constitutive Promoters - Berkeley
Part Characterization
23
DNA Repository
24
DNA Repository
  • All parts sent to teams
  • Parts are from previous teams

25
Robotic Assembly
26
DNA Synthesis Offer
GENEART synthetic DNA offer for iGEM teams
  • All you want at 0.70 per base
  • 100,000 bases total at 0.25 per base
  • About 2000 bases per team for 500
  • GENEART is a primary sponsor of iGEM 2007

http//www.geneart.com/index.php?id252
27
New Programs
  • BioBrick Part Program
  • iGEM in Europe
  • Registry in Europe
  • New Registry Workshop
  • Standards Workshop
  • iGEM Steering Committee

28
Standards
  • Device Families
  • Protein DNA logic
  • Post-translational control
  • RNA-based control
  • Localization
  • Measurement
  • Input and Outputs
  • (PoPS - Polymerase Per Second)
  • Genetic stability
  • Cross-lab consistency
  • Operating Environment
  • Load on the cell
  • Environmental impact on performance
  • Models

29
Sponsors
  • National Science Foundation
  • SynBERC
  • CSBi
  • GENEART
  • Microsoft Research
  • Biological Engineering - MIT

30
Teachers Workshops
  • MIT May 26th
  • China June 16-17
  • Zurich June 27th
  • Hands-on training
  • Future instructors welcome

31
How can I participate?
  • Organize a team for 2008
  • Volunteer for the BioBrick parts program.
  • Join the Awards committee
  • Be a judge
  • Have your lab join the Registry
  • Contribute parts to the Registry
  • Use BioBrick part standards
  • Help raise money for teams and ambassadors
    in your area.
  • Join iGEM committees (see the wiki)
  • Join iGEM in Europe
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