Gene Mutation - PowerPoint PPT Presentation

Loading...

PPT – Gene Mutation PowerPoint presentation | free to download - id: 14b85c-NzAzM



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

Gene Mutation

Description:

How are mutations detected in humans? *Pedigree analysis *Cells cultured in vitro. Analysis of enzyme activity, sequencing of proteins and DNA ... – PowerPoint PPT presentation

Number of Views:1737
Avg rating:3.0/5.0
Slides: 10
Provided by: ksz
Learn more at: http://www.csub.edu
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: Gene Mutation


1
Gene Mutation
Mutation
Chromosome mutations/aberrations
Classification of Mutations
1. Spontaneous vs. Induced Spontaneous mutation
Induced mutation
2. Gametic vs. Somatic Somatic mutation
Gametic mutation
3. Other categories
2
Gene Mutation
How are mutations detected in humans?
Pedigree analysis
Cells cultured in vitro Analysis of enzyme
activity, sequencing of proteins and DNA
The molecular basis of mutation (Point mutations)
1. Base substitution transition transversion
2. Frame shift
3. Tautomeric shift
4. Base analogs
5. Chemical mutagens
3
Gene Mutation
3.Ionizing radiation
The molecular basis of mutation (Structural
damage)
1. Missing bases
N-glycosidic bond very weak and easily broken
4
Gene Mutation
Mutations in humans
ABO Blood Types
A
A
5
Gene Mutation
DNA Repair
1. Photoreactivation
PRE photoreactivation enzyme
6
Gene Mutation
3. Excision repair
DNA Repair
2. 3 to 5 exonuclease activity of DNA
polymerases
7
Gene Mutation
3. Excision repair
8
Gene Mutation
4. Post-replication repair (recombination repair)
recombined
9
Gene Mutation
5. Inducible repair or SOS (prokaryotes)
Its better to be a mutant than be dead!
About PowerShow.com