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Tissues Response to Mechanical Stimuli

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Tissue loss is an increasing problem in today's society. It will effect almost everyone from astronauts in space to sick and injured ... – PowerPoint PPT presentation

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Title: Tissues Response to Mechanical Stimuli


1
Tissues Response to Mechanical Stimuli
  • By
  • Christopher Gambino
  • Mentors
  • Engin Ozcivici ,Shiyun Xu,
  • Russell Garman, Dr. Stefan Judex

2
Introduction
  • Tissue loss is an increasing problem in todays
    society.
  • It will effect almost everyone from astronauts in
    space to sick and injured people that require bed
    rest.
  • Many methods to prevent this loss have been tried
    from exercise to medication.
  • During this research it was noticed that some
    strains of mice lose tissue faster than others.

3
Methods
  • Resistant and susceptible strains of mice were
    crossbred to create an inbred F2 population.
  • These mice were then scanned at the age of 17
    weeks.
  • They then had their hind-limbs immobilized to
    simulate spaceflight or bed rest.
  • After 3 weeks of this they are scanned again for
    a second time.
  • The hind-limbs were then re-mobilized and the
    mice were allowed to use them for an additional 3
    weeks before being scanned 3rd and final time.

4
Results
  • During the 1-3 week period bone volume decreased
    an average of 1.
  • During the 3-6 week period bone volume increased
    an average of 4
  • During weeks 1-3 the muscle volume decreased and
    average of 10
  • During Weeks 4-6 muscle mass volume increased 7

5
Discussion
  • The bone seemed to be more responsive to
    mechanical loading (walking) than unloading
    (immobilized).
  • The reverse of this is true for the muscle.
  • The distribution of loss/gain rather than being
    grouped around one value suggests that there is a
    controlling factor that was spread through the
    genetically heterogeneous population.

6
Future Research
  • Data on different sections of bone is needed and
    is currently being worked on.
  • Further research into the genetics of the
    individual mouse is needed to isolate any
    controlling factor.
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