EpsteinBarr Virus

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Epstein-Barr Virus

• Narina Pusaard
• 44043057
• Department of Genetics

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How was the EBV discovered?

• 1961 Dr. Denis Burkitt

Burkitts lymphoma

• 1964 Epstein, Barr and Achong

Epstein-Barr Virus (EBV)

• a member of the herpesvirus family

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Structure
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Morphology

• double stranded
• circular DNA
• Icosahedral
• Envelope
• gp350 gp220

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Translocation of EBV through the genome. This
erroneous copying can lead to cancer.
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B-cell and antibody
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How is the EBV spread?
Kissing disease

• Saliva

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Infection
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Target host cells
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Burkitt's lymphoma
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Target host cells
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Mononucleosis
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B-cell lymphoma
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Nasopharyngeal carcinoma
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How we can detect this EBV?

• The Check4-IM ONE-STEP IMMUNOCHROMATOGRAPHIC TEST

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The search for a Vaccine

• A Whole Virus Vaccine

• Synthetic Peptide Vaccines

gp340/ISCOMs HLA B8 restricted epitope from
EBNA-3A

• Recombinant Vector Vaccines

Recombinant vaccina viruses Oka vaccine strain
of varicella zoster virus
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Reference

• www.diseasedir.org.uk/infect/vir02.htm
• www.brown.edu/Courses/Bio_160/Projects2000/Herpes/
  EBV/EBV-Vaccines.html
• www.cdc.gov/ncidod/diseases/ebv.htm
• www.east- buc.k12.ia.us/03_04/Disease.htm
• www.quadratech.co.uk/rassays/C4inmono.htm
• http//kidshealth.org/parent/infections/bacterial_
  viral/mononucleosis_p4.html
• http//classes.kumc.edu/sah/cls548/hetro.htm
• http//medinfo.ufl.edu/year2/mmid/bms5300/bugs/vir
  alfam.html
• http//www.uq.edu.au/vdu/EBV.htmLatent

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