Oral Infections - PowerPoint PPT Presentation

Loading...

PPT – Oral Infections PowerPoint presentation | free to download - id: 11e32f-OTYwN



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

Oral Infections

Description:

Acute pseudo- membranous. candidosis. Acute erythematous candidosis. Actinomycosis. Herpes simplex ... At birth oral cavity is sterile. Most species acquired ... – PowerPoint PPT presentation

Number of Views:330
Avg rating:3.0/5.0
Slides: 23
Provided by: auth159
Learn more at: http://www.bsmt.org.uk
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: Oral Infections


1
Oral Infections
Acute pseudo- membranous candidosis
Herpes simplex
Acute erythematous candidosis
Actinomycosis
  • Dr Ian Douglas
  • University of Sheffield

2
Acquisition of oral flora
  • At birth oral cavity is sterile
  • Most species acquired during the first 2 years of
    life
  • Flora mainly acquired from mother
  • its all in a kiss!

3
Acquisition of mutans streptococci
4
Plaque -in vivo biofilm
5
Dental caries
6
Stephan Curve
pH in plaque
pulses
Hours
7
Prevalence of some bacteria in caries
8
Mechanical removal of plaque?
Toothbrush bristle
9
Topical passive immunisation
  • Anti S.mutans s-IgA cloned into tobacco
  • 3 week application eliminated oral S.mutans

10
Replacement Therapy -Superbugs
bacteriocin
  • Potent bacteriocin
  • producer
  • Stable LDH-deficient
  • mutant
  • Produces ethanol
  • other acids

S
  • Imported adh gene

bacteriocin
bacteriocin
11
Destructive Periodontitis
12
Disease Progression
13
Association of organisms with disease
A.odontolyticus V.parvula
Pr.intermedia At.actinomycetemcomitans Pr.nigresce
ns F.nucleatum Pt.micros C.rectus
Disease
Health
S.mitis S.oralis S.sanguis
P.gingivalis Ta.forsythus T.denticola
14
Periodontal species detected by 16srRNA
  • Estimate 415 species
  • 40 were novel phylotypes
  • Detected in at least four diseased subjects, but
    not in healthy subjects

Paster B J Bact 2001 183 3770-3783
15
Periapical disease
16
Bacteria associated with endodontic treatment
failure
17
Spread of infection from the tooth
18
Examples of oral abscesses
19
Bacterial genera in periapical abscesses
most frequently recovered
20
Antibiotic sensitivity among oral anaerobes
Kuriyama et al 2001
21
ß-lacatmase in Prevotella isolates
22
Summary
  • Oral infections are polymicrobial
  • Generally caused by endogenous commensal species
  • There is relatively little microbial specificity
    for the different types of lesion (except dental
    caries?)
  • Some oral infections pose treatment problems due
    to antimicrobial resistance
About PowerShow.com