Picornaviruses Enteroviruses

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PicornavirusesEnteroviruses
Molecular Classification of enteroviruses (by
genome sequence)
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Genetic relatedness of Picornaviruses
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Polio Eradication and Vaccination
Poliovirus disease 2006 Jan-May 06 452 Cases
Poliovirus disease 2007 Jan-May 07 183 Cases
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VDPV Vaccine-derived Polio viruses

• With the Polio MLV (Sabin Oral PV vaccine)
  significant disease can arise by back mutation in
  areas of low rates of vaccination Afganistan,
  Pakistan, India and Nigeria

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Recent data with Hepatovirus (Hep A) Vaccine
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Recent data with Hepatovirus (Hep A) Vaccine
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Genome organization Picorna- compared to Calici-
Picronaviridae
Caliciviridae
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Genome organization Hepeviridae Hep E
Another viral gene Methyl Transferase
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Hepatitis viruses
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Togavirus Genomes
Review ns gene functions
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Togaviruses
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Arthropod-Borne virusesMosquito-borne
Vector Competence Sufficient virus is taken up
in a blood meal Virus Replicates
Virus is transmitted via Salivary Gland
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An Example of an RNA virus Recombinant
WEE has ns genes from New world Alphaviruses,
but structural genes from old world
Alphaviruses
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Gene Expression Glycoprotein Maturation Golgi
Proteases, Miristylation, Oligomerization,
Glycosylation
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Transmission Cycles The virus alternates between
insects and birds or insects and mammals
YF Yellow Fever Dengue Flaviviruses
An EEV Cycle, a Togavirus
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The ARBOviruses of Toga- and Flaviviruses are
geographically delineated