Workshop I

1
Workshop I

• Drug transporters.
• Can they be modelled?
• Chairman Colin Edge
• Organiser David Manallack

Drug Transporters Workshop 14th European QSAR
Symposium Sept 10th
2
Drug Transporters - Outline

• Chairmans introduction - Colin Edge
• Introduction - Han van de Waterbeemd
• Chairmans comments
• Poster presenters invited speakers
• Chairmans summary

Drug Transporters Workshop 14th European QSAR
Symposium Sept 10th
3
Drug Transporters - Format

• Interactive session.
• Ask questions as we go. time limitations
• Flipcharts to aid discussion
• Try and provide ideas for future research

Drug Transporters Workshop 14th European QSAR
Symposium Sept 10th
4
Drug Transporters - important?

• Neurotransmitter uptake blockers
• GSK drugs

!
Seroxat (paroxetine)
Wellbutrin (bupropion)
Drug Transporters Workshop 14th European QSAR
Symposium Sept 10th
5
Drug Transporters - important?

• MDR (PGP) substrates/inhibitors

Verapamil
Doxorubicin
Itraconazole
Dexamethasone
Loperamide
Drug Transporters Workshop 14th European QSAR
Symposium Sept 10th
6
Drug Transporters - important?

• Some other transporters that interact with known
  drugs
• BRT, DHA, DrugE, EST, FBT, GlyC, HAE, MATE, MC,
  MCP, MET, NAT, NCS, OAT, OCT, OMF, PAT, PDR, PPP,
  POT, QAT, RFC, SET, SSS, VNT,...

Drug Transporters Workshop 14th European QSAR
Symposium Sept 10th