BIO plus Nanotechnology Newcastle, UK

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BIO plus Nanotechnology _at_ Newcastle, UK

• Professor Jeremy Lakey
• School of Cell and Molecular Biosciences
• Part 1 The Institute for Nanotechnology
• Part 2 A Bio-Nano spin -out company

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MST / Nanotechnology at Newcastle

• Multidisciplinary Institute for Nanotechnology
• 15 research groups from Faculties of Medicine,
  Engineering Science (most RAE 5/5 in 2001,
  12M in current peer reviewed research grants,
  6.7M SRIF, DTI RDA funding in 2001/2)
• One of a small number of large cross-disciplinary
  strategic research initiatives in the university
• Strong biomedical focus
• Medical School is number two in the country in
  RAE/breadth terms
• Large market for nanotechnology
• Lead component of the DTI-funded University
  Innovation Centre for Nanotechnology
• One of three large DTI-funded nanotechnology
  initiatives
• Close working relationship with ONE NorthEast
  Inward Investment Team (ITS, Invest UK etc) and
  Cluster Development Initiatives

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Facilities

• 2500 m2 facility (with 230 m2 cleanroom)
  supporting
• silicon, glass, polymer bio-hybrid device RD,
  fabrication, packaging and evaluation
• prototype development small-series production
• training
• licensing spin-off activity
• external partners and customers
  (academic/industry, regional, national and
  international)

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Convergence at the small scale

• Sub-nanometer precision figuring polishing
• Self-organised nanowire arrays
• Multi-axis gyros
• Micro-reactor technology
• Nanoparticles tissue engineering
• Biosensors, diagnostic devices, arrays
• Biological/physical interface

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Precision Figuring Polishing(Prof. Ken Snowdon)

• Figuring
• nm-precision ion beam erosion (e.g. Zeiss)
• Polishing
• CaF2, final rms 1.2 Å (?5 improvement over
  mechanical polishing)

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2. Self-Organised Nanowire Arrays(Prof. Ken
Snowdon)

• Directed stress-field induced self-ordering
  (lattice mismatch glancing incidence ion beam
  irradiation)
• Exceptional long range order (constant
  separation perfect wire alignment, gt50
  oscillations visible in ACF)
• Applications as notch filters, nanoelectrodes,
  atom-optics, cross-wire array architectures
• Spin-off Jan. 2001

49?49 ?m2
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3. Multi-Axis Gyros(Prof. Jim Burdess Dr Alun
Harris)

• Exploits coriolis coupling between the in-plane
  out-of-plane modes (3-axis)
• Pyrex-Si-Pyrex bonded sandwich, lt111gt Si ring
• Ring radius 4 mm

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4. Micro-Reactor Technology(Prof. Colin Ramshaw)

• Capillary reactors for e.g. point-of-use chemical
  manufacture (utilise rapid heat and mass transfer
  inside narrow sub-mm channels to provide
  intensified regimes for mass transfer limited
  processes).
• Compact spinning disk reactors for the
  point-of-use manufacture of liquid and solid
  (nanoparticulate) products composites.
• Spin-off - Protensive

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5. Nanoparticles Tissue Engineering(Prof.
Galip Akay)

• Use of a cold-flow induced phase inversion
  technique to produce a novel porous organic
  material with a narrow pore-size distribution
• template for tissue growth (bone, cartilage,
  macrophage, etc. cells)
• nanoparticle self-assembly
• scaffold

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6a. Biomolecular Electronics(Drs Ben Horrocks
Andrew Houlton)

• Integration of (bio)molecular compounds with
  semiconductor materials for applications in
  sensing, molecular electronics and
  nanotechnology.
• Significant development has been synthesis of
  artificial DNA directly onto non-oxidised silicon
  allows direct read-out via electron transfer to
  Si.

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6b. Cell Chips(Prof. Calum McNeil)

• Detect transient changes in cell membrane
  potentials
• Monitor real-time response of cell systems to
  external physical or chemical stimuli
• e.g. influence of drugs on cardiac frequency
  (recorded in minutes)
• Drug screening applications

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7. Nanoengineered Biological-Physical-Information
Interface

• Robust fully communicating interface between
  physical, information and biological environments
• Platform with exciting applications in e.g.
  health, environmental, process monitoring,
  communications, leisure and defence sectors.

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Integration of Sensors, IT Comms Super
Technology
Source NTT
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Summary

• Comprehensive facilities and people (most RAE
  5/5 in 2001) with breadth of RD activity
• NST/MST (device and process development in both
  conventional and unconventional materials)
• Hybrid device and process development
• Self-assembly and self-organisation process
  development and integration with top-down
  fabrication technologies
• Integrated ST and commercialisation model
• gt50 industry usage of facilities, plus spin-offs
• Offer base for private-sector exploratory and
  new-product development activity and small batch
  production
• Strong biomedical focus

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Part 2. A Bio-Nano spin out company. Interfacing
biology and physical science throughnanoscale
engineering
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The Dynamic Interface
Aqueous Environment Diagnostic/therapeutic Bio
molecules, Cells in culture, Living tissue
The BIO- interface
Physical Devices semi-conductors,
optoelectronics, biosensors, biomimetics,
implanted materials
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Self-assembly soluble proteins
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Nature
Nanotech
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Self-assembly .outer membrane proteins
and phospholipids
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Integrating biological systems and physical
devices through engineered protein interfaces

• The ideal biological interface should exhibit
• Self-assembly
• Functional biochemical sites presented at a
  nano-scale
• A truly biomimetic surface
• Capable of industrial manufacture (robustness,
  compatibility, reproducibility)
• Show stability at the physical interface

Orla is harnessing nature for the solution
through use of membrane protein scaffolds
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Core Technology Engineered protein interface
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Markets and Application areas
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Some Omp are pore -forming proteins
-

105-108 ions per second per pore !
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Orla Protein Technologies LtdNanotechnology
Centre,Herschel Building,Newcastle Upon
Tyne,NE1 7RUTel (0) 191 243 0683Fax (0)
191 222 3528enquiries_at_orlaproteins.com
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• Newcastle
• Graeme Bainbridge
• Qi Hong
• Dave Chalton
• Neil Keegan
• Virak Visudtipole

• Glasgow
• Alan Cooper
• Lausanne
• Horst Vogel
• Thierry Stora
• Samuel Terretaz,
• Claus Duschl

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THE END

• THE BASIC SCIENCE WAS SUPPORTED BY
• BBSRC, EPFL
• AND THE UNIVERSITY OF NEWCASTLE