Effects of adding biphasic, prandial, or basal insulin to maximum oral T2DM therapy

1
Effects of adding biphasic, prandial, or basal
insulin to maximum oral T2DM therapy
Treating to Target in Type 2 Diabetes (4-T)
25 20 15 10 5 0
20 10 0 -10 -20 -30 -40
Mean relative change()
No.events/ patientper yr
A1C
Fasting plasma glucose
Post-prandial glucose
Body weight
Hypoglycemia grade 2 or 3
8.5
173 mg/dL
227 mg/dL
85.8 kg
Baseline value
Biphasic insulin
Prandial insulin
Basal insulin
Holman RR et al. N Engl J Med. 2007357.