OI Radiologic Findings - PowerPoint PPT Presentation

Loading...

PPT – OI Radiologic Findings PowerPoint presentation | free to download - id: 114b33-YzUwY



Loading


The Adobe Flash plugin is needed to view this content

Get the plugin now

View by Category
About This Presentation
Title:

OI Radiologic Findings

Description:

Osteogenesis imperfecta (OI) also known as Brittle Bone Disease, heritable ... Early Bisphosonate Treatment in Infants with Severe Osteogenesis Imperfecta. ... – PowerPoint PPT presentation

Number of Views:315
Avg rating:3.0/5.0
Slides: 20
Provided by: wilso96
Category:

less

Write a Comment
User Comments (0)
Transcript and Presenter's Notes

Title: OI Radiologic Findings


1
OI Radiologic Findings
  • Wil File
  • Radiology Rotation
  • M4 Student Presentations
  • 8/22/06

2
  • Osteogenesis imperfecta (OI) also known as
    Brittle Bone Disease, heritable disorder of
    connective tissue with 4 subtypes.
  • Hallmark feature is bone fragility, with a
    tendency to fracture from minimal trauma.

3
Incidence
  • Incidence of forms of OI recognizable at birth is
    1/20,000.
  • Incidence of mild forms not recognizable until
    later in life is 1/21,000
  • OI Marfans Syndrome are the most common
    heritable connective tissue disorders
  • No racial or ethnic predilection

4
Subtypes of OI
5
History/Physical Points in OI
  • History/Physical
  • frequent fractures, minimal trauma
  • deafness
  • blue sclerae
  • easy bruisability
  • joint laxity
  • discolored or softened teeth (dentinogenesis
    imperfecta)
  • short stature
  • abnormal skull shape
  • heat intolerance or excessive sweating
  • family history of above features

6
X-ray Findings
  • Fractures of all types occur in OI
  • No consistent pattern of fracturing, many
    individuals have long fracture-free periods
  • Can be seen in antenatal US diagnosed with CVS

7
Wormian Bones
8
Basilar Invagination
9
(No Transcript)
10
(No Transcript)
11
(No Transcript)
12
(No Transcript)
13
Spinal Findings
14
OI vs. Child Abuse
15
Common Abuse Fracture
16
Diagnostic Workup
  • History/PE findings consistent with OI
  • May need skin biopsy (collagen study), blood
    sample (DNA analysis) or bone histology to make
    definitive diagnosis
  • DEXA of lumbar vertebral bodies for relatively
    quantitative assessment of pt.s osteoporosis

17
Treatment
  • Conventional intensive physical rehabilitation,
    with orthopedic intervention as needed.
  • Pharm bisphosphonates

18
Neuffer Teaching Point
  • Yes his heart is a little large and no it is not
    supposed to touch the left chest wall and yes
    this is consistent with LV hypertrophy BUT it
    does NOT take away the fact that this guy is
    sh---ing all over his peritoneum.
  • -Dr. Neuffer

19
Worked Cited
  • Wendy, Lane. Diagnosis and Management of
    Physical Abuse in Children. Clinical Family
    Practice 2005 Jun 5(2) 493.
  • Antonazzi, Franco, Zamboni, Gorgio. Early
    Bisphosonate Treatment in Infants with Severe
    Osteogenesis Imperfecta. Journal of Pediatrics
    01-Aug-2006 149(2)174-179.
  • Behran, Kliegman, Arvin. Osteogenesis
    Imperfecta. Nelson Textbook of Pediatrics 17th
    Ed. 2336-2338.
  • Beary, John F.,Chines, Arkadi. Clinical Features
    and Diagnosis of Osteogenesis Imperfecta.
    UpToDate Accessed August 20, 2006
About PowerShow.com