Genetics

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Genetics Meiosis

• IB Unit 3 2006

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FIGURE 12-1
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Sickle Cell Anemia

• Cause Missense mutation
• Hydrophillic amino acid is changed to a
  hydrophobic amino acid
• Hemoglobin proteins stick together b/c
  hydrophobic regions interact
• Result Sickle shaped cells

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Phenotype

• Sickle shaped cells block vessels

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Phenotype/Symptoms

• Oxygen carrying RBCs blocked from reaching
  tissues
• Pain
• Pain results from tissues dying due to lack of
  oxygen
• Why does lack of oxygen kill cells?
• Fatigue
• Why does lack of oxygen cause fatigue?

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Inheritance Pattern

• Blood of a heterozygous individual What is the
  inheritance pattern of this disease?

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Malaria

• Parasite carried/spread by mosquitoes
• Causes severe fever and death

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Value of Mutations

• Sickle shaped cells are resistant to malaria!
• Survival of genotypes in Africa

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FIGURE 9-13
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FIGURE 9-16
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FIGURE 9-20
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FIGURE 9-18
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FIGURE 9-19
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FIGURE 10-14