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Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Design and High-Throughput Synthesis and Screening PowerPoint PPT Presentation
Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Design and High-Throughput Synthesis and Screening - ... nosocomial infections, pneumonia ... Goal and methods Design novel DHFR ... Diversity-based library design Known potent compounds had high molecular ...
... nosocomial infections, pneumonia ... Goal and methods Design novel DHFR ... Diversity-based library design Known potent compounds had high molecular ...
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Dihydrofolate Reductase as a Paradigm of Rational Drug Design PowerPoint PPT Presentation
Dihydrofolate Reductase as a Paradigm of Rational Drug Design - Dihydrofolate Reductase as a Paradigm of Rational Drug Design ... the steric effect and greater the density, the smaller the steric effect (the ...
Dihydrofolate Reductase as a Paradigm of Rational Drug Design ... the steric effect and greater the density, the smaller the steric effect (the ...
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Synthesis, Molecular Modeling, and Dihydrofolate Reductase Inhibition Activity of Some New 43Hquinaz PowerPoint PPT Presentation
Synthesis, Molecular Modeling, and Dihydrofolate Reductase Inhibition Activity of Some New 43Hquinaz - DHFR functions as a catalyst for the reduction of dihydrofolate to tetrahydrofolate. ... Bovine liver DHFR was used for the assay. It is 70% homologous to hDHFR. ...
DHFR functions as a catalyst for the reduction of dihydrofolate to tetrahydrofolate. ... Bovine liver DHFR was used for the assay. It is 70% homologous to hDHFR. ...
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?????????Alimta????? PowerPoint PPT Presentation
?????????Alimta????? - ... Dihydrofolate reductase ...
... Dihydrofolate reductase ...
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Dr. Lilach Sheiner’s accent? PowerPoint PPT Presentation
Dr. Lilach Sheiner’s accent? - Dr. Lilach Sheiner s accent? * * * * * * * * * * * * * * * * * * Antifolates as malaria drugs Dihydrofolate Tetrahydrofolate Nucleotide synthesis GTP Dihydrofolate ...
Dr. Lilach Sheiner s accent? * * * * * * * * * * * * * * * * * * Antifolates as malaria drugs Dihydrofolate Tetrahydrofolate Nucleotide synthesis GTP Dihydrofolate ...
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Enseignements Dirig PowerPoint PPT Presentation
Enseignements Dirig - ... Cas clinique n 2 M thotrexate ( Novatrex) : Inhibiteur de la dihydrofolate r ductase, effet immunomodulateur puissant Utilis faible dose ...
... Cas clinique n 2 M thotrexate ( Novatrex) : Inhibiteur de la dihydrofolate r ductase, effet immunomodulateur puissant Utilis faible dose ...
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Protein Purification: From industrial enzymes to cancer therapy PowerPoint PPT Presentation
Protein Purification: From industrial enzymes to cancer therapy - ... protein expression and purification for biomanufacturing Dihydrofolate reductase Affinity purification Perform affinity chromatography Perform size exclusion ...
... protein expression and purification for biomanufacturing Dihydrofolate reductase Affinity purification Perform affinity chromatography Perform size exclusion ...
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Biosynthesis of Nucleotides and Nucleic Acids PowerPoint PPT Presentation
Biosynthesis of Nucleotides and Nucleic Acids - cells have a requirement for the synthesis of new DNA. ... Thymidylate synthase and dihydrofolate reductase, enzymes critical for ...
cells have a requirement for the synthesis of new DNA. ... Thymidylate synthase and dihydrofolate reductase, enzymes critical for ...
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Folate Folacin, folic acid, PGA (pteroylglutamic acid PowerPoint PPT Presentation
Folate Folacin, folic acid, PGA (pteroylglutamic acid - Folate Folacin, folic acid, PGA (pteroylglutamic acid) Functions Coenzyme in DNA synthesis and cell division Coenzyme THF (tetrahydrofolate); DHF(dihydrofolate ...
Folate Folacin, folic acid, PGA (pteroylglutamic acid) Functions Coenzyme in DNA synthesis and cell division Coenzyme THF (tetrahydrofolate); DHF(dihydrofolate ...
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ReadingChapter 14 PowerPoint PPT Presentation
ReadingChapter 14 - HMG-CoA reductase inhibitor. Lowers LDL cholesterol. Celecoxib (Celebrex) COX-2 inhibitor ... Inhibits dihydrofolate reductase. Anticancer agent (leukemia) ...
HMG-CoA reductase inhibitor. Lowers LDL cholesterol. Celecoxib (Celebrex) COX-2 inhibitor ... Inhibits dihydrofolate reductase. Anticancer agent (leukemia) ...
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One-Carbon Metabolism PowerPoint PPT Presentation
One-Carbon Metabolism - Title: No Slide Title Author: E.D. Harris Last modified by: E.D. Harris Created Date: 3/4/1999 3:02:17 PM Document presentation format: On-screen Show
Title: No Slide Title Author: E.D. Harris Last modified by: E.D. Harris Created Date: 3/4/1999 3:02:17 PM Document presentation format: On-screen Show
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One Carbon Pool By Folate PowerPoint PPT Presentation
One Carbon Pool By Folate - Folic Acid. HMDB00121. ONE CARBON POOL BY FOLATE. In Homo sapiens ... 5,10- methenyl THF. HMDB01354. Phosphoribosylglycinamide. formyltransferase. A8KA32 ...
Folic Acid. HMDB00121. ONE CARBON POOL BY FOLATE. In Homo sapiens ... 5,10- methenyl THF. HMDB01354. Phosphoribosylglycinamide. formyltransferase. A8KA32 ...
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Pyrimidine Metabolism/Disease PowerPoint PPT Presentation
Pyrimidine Metabolism/Disease - Title: No Slide Title Author: Raymond Birge Last modified by: suriender kumar Created Date: 9/28/2010 12:38:24 PM Document presentation format: On-screen Show (4:3)
Title: No Slide Title Author: Raymond Birge Last modified by: suriender kumar Created Date: 9/28/2010 12:38:24 PM Document presentation format: On-screen Show (4:3)
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Pyrimidine nucleotide biosynthesis PowerPoint PPT Presentation
Pyrimidine nucleotide biosynthesis - Uracil is the precursor of all pyrimidine nucleotides. ... R = CH3, methotrexate. Aminopterin and methotrexate inhibit DHFR and are used ...
Uracil is the precursor of all pyrimidine nucleotides. ... R = CH3, methotrexate. Aminopterin and methotrexate inhibit DHFR and are used ...
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methyleneH4folate PowerPoint PPT Presentation
methyleneH4folate - Title: Slide 1 Author: Bryn Mawr College Last modified by: Bryn Mawr College Created Date: 4/14/2011 2:59:59 PM Document presentation format: On-screen Show (4:3)
Title: Slide 1 Author: Bryn Mawr College Last modified by: Bryn Mawr College Created Date: 4/14/2011 2:59:59 PM Document presentation format: On-screen Show (4:3)
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Protein Identification by Peptide Mass Fingerprinting PowerPoint PPT Presentation
Protein Identification by Peptide Mass Fingerprinting - Protein Identification by Peptide Mass Fingerprinting. Aim: ... Three types of scores. Shared peaks count: simply counts the number of matched mass values (peaks) ...
Protein Identification by Peptide Mass Fingerprinting. Aim: ... Three types of scores. Shared peaks count: simply counts the number of matched mass values (peaks) ...
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21' Deoxyribonucleotide biosynthesis and nucleotide catabolism PowerPoint PPT Presentation
21' Deoxyribonucleotide biosynthesis and nucleotide catabolism - Thymidylate synthase oxidizes N5,N10-methylenetetrahydrofolate to ... Fish and most terrestrial mammals oxidize uric acid further before excreting the ...
Thymidylate synthase oxidizes N5,N10-methylenetetrahydrofolate to ... Fish and most terrestrial mammals oxidize uric acid further before excreting the ...
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26' Deoxyribonucleotide biosynthesis and nucleotide catabolism drug design and testing PowerPoint PPT Presentation
26' Deoxyribonucleotide biosynthesis and nucleotide catabolism drug design and testing - 26. Deoxyribonucleotide biosynthesis and nucleotide catabolism; drug design and testing ... Enzymes of nucleotide biosynthesis provide targets for cancer ...
26. Deoxyribonucleotide biosynthesis and nucleotide catabolism; drug design and testing ... Enzymes of nucleotide biosynthesis provide targets for cancer ...
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Regulation of gene expression PowerPoint PPT Presentation
Regulation of gene expression - Mechanisms by which expression of genes is regulated in prokaryotes and eukaryotes
Mechanisms by which expression of genes is regulated in prokaryotes and eukaryotes
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Exercises in protein structure PowerPoint PPT Presentation
Exercises in protein structure - How many atoms from each subunit are involved (distance 7 ) ... (1L17), what do you predict will happen if L121 is mutated to an arginine? What about R96-- L? ...
How many atoms from each subunit are involved (distance 7 ) ... (1L17), what do you predict will happen if L121 is mutated to an arginine? What about R96-- L? ...
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Gene amplification for high level production in CHO dhfr- cells. PowerPoint PPT Presentation
Gene amplification for high level production in CHO dhfr- cells. - Title: Slide 1 Author: Lawrence Chasin Last modified by: Lawrence Chasin Created Date: 11/17/2009 5:51:05 PM Document presentation format: On-screen Show
Title: Slide 1 Author: Lawrence Chasin Last modified by: Lawrence Chasin Created Date: 11/17/2009 5:51:05 PM Document presentation format: On-screen Show
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Cancer Detection and Diagnosis PowerPoint PPT Presentation
Cancer Detection and Diagnosis - Cancer Detection and Diagnosis Early Cancer May Not Have Any symptoms Pap Test Mammograms Blood tests Mammograms Mammograms Mammograms Mammograms
Cancer Detection and Diagnosis Early Cancer May Not Have Any symptoms Pap Test Mammograms Blood tests Mammograms Mammograms Mammograms Mammograms
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Rgulation de la production dun nuclotide triphosphate PowerPoint PPT Presentation
Rgulation de la production dun nuclotide triphosphate - Quitter. Contenu. Here are the four different. ribonucleoside diphosphates. which are converted, by ... Quitter. Contenu. Index. Tutoriale. Recommencer. Deux ...
Quitter. Contenu. Here are the four different. ribonucleoside diphosphates. which are converted, by ... Quitter. Contenu. Index. Tutoriale. Recommencer. Deux ...
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The%20Practical%20Side%20of%20Nucleotide%20Metabolism PowerPoint PPT Presentation
The%20Practical%20Side%20of%20Nucleotide%20Metabolism - Finish up Tuesday's Leftovers. Brief Explanation of how dUMP is converted to dTMP. Some clinically relevant treatments based on these pathways that are used to combat: ...
Finish up Tuesday's Leftovers. Brief Explanation of how dUMP is converted to dTMP. Some clinically relevant treatments based on these pathways that are used to combat: ...
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Laboratoire de Pharmacologie Facult PowerPoint PPT Presentation
Laboratoire de Pharmacologie Facult - Title: Les cyclines Author: PHARM-HANEN Last modified by: hanene Created Date: 1/1/1988 7:04:29 AM Document presentation format: Affichage l' cran
Title: Les cyclines Author: PHARM-HANEN Last modified by: hanene Created Date: 1/1/1988 7:04:29 AM Document presentation format: Affichage l' cran
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SULFONAMIDES PowerPoint PPT Presentation
SULFONAMIDES - ADVERSE EFFECTS Hypersensitivity reactions -common allergic rashes ... (sulfadoxine) THERAPEUTIC USES Parasitic diseases (combined with other antimicrobials ...
ADVERSE EFFECTS Hypersensitivity reactions -common allergic rashes ... (sulfadoxine) THERAPEUTIC USES Parasitic diseases (combined with other antimicrobials ...
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BIOCHEMISTRY OF FOLATE PowerPoint PPT Presentation
BIOCHEMISTRY OF FOLATE - biochemistry of folate and vitamin b12: oct 1, 2014 basic biochemical pathways
biochemistry of folate and vitamin b12: oct 1, 2014 basic biochemical pathways
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b-???? PowerPoint PPT Presentation
b-???? - Title: PowerPoint Author: VAIO Last modified by: pharm Created Date: 10/3/2003 1:43:49 AM Document presentation format:
Title: PowerPoint Author: VAIO Last modified by: pharm Created Date: 10/3/2003 1:43:49 AM Document presentation format:
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Molecular%20Methods%20of%20cell%20culture%20I PowerPoint PPT Presentation
Molecular%20Methods%20of%20cell%20culture%20I - Title: Author: CS907 Last modified by: Jamie Created Date: 11/24/1999 2:01:16 AM Document presentation format: (4:3)
Title: Author: CS907 Last modified by: Jamie Created Date: 11/24/1999 2:01:16 AM Document presentation format: (4:3)
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Enzymes%20as%20diagnostic%20 PowerPoint PPT Presentation
Enzymes%20as%20diagnostic%20 - (Use in alzheimer disease, glaucoma) ... Statins inhibit this enzyme, ... Clinical Enzymology Author: Haiza Last modified by:
(Use in alzheimer disease, glaucoma) ... Statins inhibit this enzyme, ... Clinical Enzymology Author: Haiza Last modified by:
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Acquired Specific Immunity PowerPoint PPT Presentation
Acquired Specific Immunity - Each one recognizes only one site of the ... Why not fuse them? ... Fuse the spleen and myeloma cells and you'll find survivors in HAT tissue culture media. ...
Each one recognizes only one site of the ... Why not fuse them? ... Fuse the spleen and myeloma cells and you'll find survivors in HAT tissue culture media. ...
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Enzyme Inhibition PowerPoint PPT Presentation
Enzyme Inhibition - Enzymology
Enzymology
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The Practical Side of Nucleotide Metabolism PowerPoint PPT Presentation
The Practical Side of Nucleotide Metabolism - Anti-Viral Therapies. HIV- Human Immunodeficiency Virus. HSV- Herpesvirus ... Acyclovir as an Anti-HSV Agent. Acyclovar (acycloguanosine)- purine analog ...
Anti-Viral Therapies. HIV- Human Immunodeficiency Virus. HSV- Herpesvirus ... Acyclovir as an Anti-HSV Agent. Acyclovar (acycloguanosine)- purine analog ...
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Predicting protein folding pathways PowerPoint PPT Presentation
Predicting protein folding pathways - Predicting protein folding pathways Predicting protein folding pathways Mohammed J. Zaki, Vinay Nadimpally, Deb Bardhan and Chris Bystroff Artikel i Bioinformatics ...
Predicting protein folding pathways Predicting protein folding pathways Mohammed J. Zaki, Vinay Nadimpally, Deb Bardhan and Chris Bystroff Artikel i Bioinformatics ...
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Hematological diseases PowerPoint PPT Presentation
Hematological diseases - Pathogenesis of Megaloblastic anemia Deficiency of Vit B12/folic acid Impairment of DNA synthesis, Results in a delay in nuclear maturation and cell division.
Pathogenesis of Megaloblastic anemia Deficiency of Vit B12/folic acid Impairment of DNA synthesis, Results in a delay in nuclear maturation and cell division.
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Michaelis-Menten kinetics PowerPoint PPT Presentation
Michaelis-Menten kinetics - is low (close to zero time) Michaelis-Menten Equation. E S ES E P. Michaelis-Menten Model ... [P] is low (close to zero. time), hence, V0 for. initial ...
is low (close to zero time) Michaelis-Menten Equation. E S ES E P. Michaelis-Menten Model ... [P] is low (close to zero. time), hence, V0 for. initial ...
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Niacin Vitamin B3 PowerPoint PPT Presentation
Niacin Vitamin B3 - 0. 4-Methyl-5-hydroxyethyl-thiazole. Methylene bridge. THIAMIN (VITAMIN B1) ... synthesis ??? catabolism ??? amino acids. ??? enzyme glycogen phosphorylase ?? ...
0. 4-Methyl-5-hydroxyethyl-thiazole. Methylene bridge. THIAMIN (VITAMIN B1) ... synthesis ??? catabolism ??? amino acids. ??? enzyme glycogen phosphorylase ?? ...
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25_Lecture.ppt PowerPoint PPT Presentation
25_Lecture.ppt - 6th Edition Paula Yurkanis Bruice Chapter 25 The Organic Chemistry of the Coenzymes, Compounds Derived from Vitamins *
6th Edition Paula Yurkanis Bruice Chapter 25 The Organic Chemistry of the Coenzymes, Compounds Derived from Vitamins *
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The relationship between chain connectivity and domain stability in the equilibrium and kinetic fold PowerPoint PPT Presentation
The relationship between chain connectivity and domain stability in the equilibrium and kinetic fold - Purpose to determine the role of domains in defining kinetic ... Urea treated mixed-bed resin before addition of buffers to remove free cyanate and ammonia. ...
Purpose to determine the role of domains in defining kinetic ... Urea treated mixed-bed resin before addition of buffers to remove free cyanate and ammonia. ...
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E. coli as a host PowerPoint PPT Presentation
E. coli as a host - E. coli as a host PROs: Easy, flexible, high tech, fast, cheap; . . . . . . but problems CONs Folding (can misfold) Sorting - can form inclusion bodies
E. coli as a host PROs: Easy, flexible, high tech, fast, cheap; . . . . . . but problems CONs Folding (can misfold) Sorting - can form inclusion bodies
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Chapter 49 Antineoplastic Drugs PowerPoint PPT Presentation
Chapter 49 Antineoplastic Drugs - Chapter 49 Antineoplastic Drugs Department of pharmacology Liu xiaokang( 2010,3 Categories: 1) Antimetabolites: a) Folic Acid Analogs (Methotrexate, MTX).
Chapter 49 Antineoplastic Drugs Department of pharmacology Liu xiaokang( 2010,3 Categories: 1) Antimetabolites: a) Folic Acid Analogs (Methotrexate, MTX).
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Purine  PowerPoint PPT Presentation
Purine - Asparate Ribose 5-phosphate PRPP Phosphoribosyl amine IMP ... Nucleotidases Nucleoside phosphorylases Deaminases Xanthine oxidases 3. the final common ...
Asparate Ribose 5-phosphate PRPP Phosphoribosyl amine IMP ... Nucleotidases Nucleoside phosphorylases Deaminases Xanthine oxidases 3. the final common ...
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Antifolates, DNA gyrase inhibitors, Novel lipopeptides PowerPoint PPT Presentation
Antifolates, DNA gyrase inhibitors, Novel lipopeptides - Title: Sulfonamides,Trimethoprim and Quinolones Last modified by: Sushike Created Date: 5/26/2003 11:39:43 PM Document presentation format ...
Title: Sulfonamides,Trimethoprim and Quinolones Last modified by: Sushike Created Date: 5/26/2003 11:39:43 PM Document presentation format ...
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Malaria pathogenesis PowerPoint PPT Presentation
Malaria pathogenesis - Malaria pathogenesis * * * * * * * * * * * * * * * * * * * * * * Resistance to chloroquine Genetic studies have shown that resistance is linked to the transporter ...
Malaria pathogenesis * * * * * * * * * * * * * * * * * * * * * * Resistance to chloroquine Genetic studies have shown that resistance is linked to the transporter ...
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BIOCHEMISTRY OF FOLATE PowerPoint PPT Presentation
BIOCHEMISTRY OF FOLATE - biochemistry of folate and vitamin b12: ... dna synthesis requires vit b12 cycle #1 cycle #2 folate provides methyl groups by two different cycles methylene-thf: ...
biochemistry of folate and vitamin b12: ... dna synthesis requires vit b12 cycle #1 cycle #2 folate provides methyl groups by two different cycles methylene-thf: ...
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Anti-parasitic%20Agents PowerPoint PPT Presentation
Anti-parasitic%20Agents - Used to treat intestinal helminth infections, especially those caused by nematodes and cestodes ... used in China for over 200 years to treat fever and chills ...
Used to treat intestinal helminth infections, especially those caused by nematodes and cestodes ... used in China for over 200 years to treat fever and chills ...
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Transfection agents: PowerPoint PPT Presentation
Transfection agents: - Last updated: Nov. 21, 2011 1:10 AM DNA transfection Transfection agents: CaPO4 (co-precipitates with DNA) Electroporation (naked DNA, high voltage pulse transient holes)
Last updated: Nov. 21, 2011 1:10 AM DNA transfection Transfection agents: CaPO4 (co-precipitates with DNA) Electroporation (naked DNA, high voltage pulse transient holes)
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Wrap up antimalarial treatment PowerPoint PPT Presentation
Wrap up antimalarial treatment - Wrap up antimalarial treatment
Wrap up antimalarial treatment
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Prof. Mohammad Alhumayyd Department of Pharmacology PowerPoint PPT Presentation
Prof. Mohammad Alhumayyd Department of Pharmacology - ... Staphylococcus Saprophyticus Chlamydia trachomatis ,Mycoplasma & N. gonorrhea (limited to urethra, unlike E.coli may be sexually transmitted) ...
... Staphylococcus Saprophyticus Chlamydia trachomatis ,Mycoplasma & N. gonorrhea (limited to urethra, unlike E.coli may be sexually transmitted) ...
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2004-2005 Pharmacology Review of Everything (Principles, Cardiovascular and Respiratory drugs have been updated) PowerPoint PPT Presentation
2004-2005 Pharmacology Review of Everything (Principles, Cardiovascular and Respiratory drugs have been updated) - 2004-2005 Pharmacology Review of Everything (Principles, Cardiovascular and Respiratory drugs have been updated) * *
2004-2005 Pharmacology Review of Everything (Principles, Cardiovascular and Respiratory drugs have been updated) * *
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Nucleic Acid Metabolism PowerPoint PPT Presentation
Nucleic Acid Metabolism - Nucleic Acid Metabolism Nucleotides Essential for all cells Carriers of activated intermediates in carbohydrate, lipids and proteins CoA FAD NAD NADP
Nucleic Acid Metabolism Nucleotides Essential for all cells Carriers of activated intermediates in carbohydrate, lipids and proteins CoA FAD NAD NADP
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ANTIMICROBIAL DRUGS-2 PowerPoint PPT Presentation
ANTIMICROBIAL DRUGS-2 - ANTIMICROBIAL DRUGS-2 Presented by: Sarbeel Al Mosddar Drugs that act on 50S subunit Chloramphenicol Antimicrobial Activity: Toxicity: MACROLIDES erythromycin ...
ANTIMICROBIAL DRUGS-2 Presented by: Sarbeel Al Mosddar Drugs that act on 50S subunit Chloramphenicol Antimicrobial Activity: Toxicity: MACROLIDES erythromycin ...
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Cancer therapy - conventional PowerPoint PPT Presentation
Cancer therapy - conventional - Cancer therapy - conventional Surgery Radiotherapy Chemotherapy Adjuvant therapies Surgery Advantages: quick & effective; largest no of cures; confirmation of ...
Cancer therapy - conventional Surgery Radiotherapy Chemotherapy Adjuvant therapies Surgery Advantages: quick & effective; largest no of cures; confirmation of ...
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METABOLISME DES BASES PURIQUES ET PYRIMIDIQUES --------------------- Hypo/Hyper uric PowerPoint PPT Presentation
METABOLISME DES BASES PURIQUES ET PYRIMIDIQUES --------------------- Hypo/Hyper uric - METABOLISME DES BASES PURIQUES ET PYRIMIDIQUES-----Hypo/Hyper uric mies Prs JC Deybach & H Puy Composants l mentaires des Ac.
METABOLISME DES BASES PURIQUES ET PYRIMIDIQUES-----Hypo/Hyper uric mies Prs JC Deybach & H Puy Composants l mentaires des Ac.
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Nucleotide Metabolism PowerPoint PPT Presentation
Nucleotide Metabolism - 9. AICAR transformylase. 10. IMP synthase. Glu, PPi. Gln. PRPP ... (AICAR) (FAICAR) Trifunctional enzyme. Potent inhibitors of purine nucleotide synthesis ...
9. AICAR transformylase. 10. IMP synthase. Glu, PPi. Gln. PRPP ... (AICAR) (FAICAR) Trifunctional enzyme. Potent inhibitors of purine nucleotide synthesis ...
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Arvutid ravimiarenduses PowerPoint PPT Presentation
Arvutid ravimiarenduses - Arvutid ravimiarenduses Mati Karelson RAVIMIARENDUSE KRONOLOOGIA Ravimiarenduse tee M ratakse haigus Isoleeritakse haigusega seotud valk (2-5 aastat) Leitakse ...
Arvutid ravimiarenduses Mati Karelson RAVIMIARENDUSE KRONOLOOGIA Ravimiarenduse tee M ratakse haigus Isoleeritakse haigusega seotud valk (2-5 aastat) Leitakse ...
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