ULTROID TECHNOLOGIES, INC'

1
ULTROID TECHNOLOGIES, INC.
2
What are Hemorrhoids?Hemorrhoids are swollen
veins

• Internal Veins inside the rectal canal
• External- Veins under the skin around the anus
• Mixed- Both internal and external

• Etiology
• Constipation
• Diarrhea
• Straining at stool
• Low fiber diet
• High in refined foods
• Pregnancy

• Clinical Symptoms
• Bright red bleeding
• Sense of fullness in anal area
• Prolapse
• Pain or discomfort
• Soiling
• Mucous discharge

3
THE MARKETHemorrhoid FACTS

• The MOST COMMON AILMENT KNOWN TO MEN AND WOMEN!
• 80 of Americans will acquire some level of
  hemorrhoids in their life time.
• 33 of pregnant women develop hemorrhoids.
• About HALF of all Americans will have hemorrhoids
  by the age of 50.
• 80 of Americans over the age of 50 will acquire
  hemorrhoids
• Onset usually occurs after the age of 30.
• Common causes prolonged sitting/standing,
• pregnancy, poor diets, constipation, straining,
  etc.
• Over-the-counter remedies at drug retail stores,
  ranking it as one of its most strategic
  products.
• SOURCE United States Agency for Healthcare
  Research Quality

4
THE MARKET

• Total Cost 1.2 Billion 174
• The US Agency for Health Care Research and
  Quality ranked hemorrhoids as the third fastest
  growing disease in a recent survey
•    
• The recorded cost of patients treated for
  symptomatic hemorrhoids increased by 23 to 1.2
  Billion.
• Approximately 45 million Americans above the age
  of 45 have symptomatic hemorrhoid disease.
• Most Americans suffer in silence, delaying
  medical treatment an average of 9 years.
• The vast majority of Americans are unaware of
  painless, non-surgical, safe and effective
  treatments for hemorrhoid disease.

5
Treatment Modalities

• Hemorrhoidectomy
• Rubber Band Ligation
• Laser
• Direct Current (Ultroid)

6
Hemorrhoidectomy

• Applicable Grades 3, 4
• Percent Success?
• Advantages
• - Useful in severe cases
• Disadvantages
• - Costly 12,000 to 15,000
• - Requires hospital stay 2-5 days
• - Extreme Pain associated
• - Takes 20-50 days to fully recover
• - Procedure related complications
  . include Death,
  bleeding,
• recurrence, incontinence, sepsis
• - Patient frequently out of work for 2-3
  weeks.

7

• JAMIE THOMPSONPublished August 21, 2005
• Erin Flatley told friends she was having mouth
• surgery. The truth was too embarrassing. She
• didn't like to talk about it, not even with her
  father,
• who already had the procedure done twice
• a hemorrhoidectomy. Doctors said it wasn't
• essential, but Erin, 23, had been having pain.
• Everyone had told her It was minor surgery,
• with major pain. They weren't worried.
• What could go wrong?

8
Rubber-Band Ligation

• Applicable Grades 1, 2, 3
• Percent Success
• 90
• Advantages
• Outpatient
• No Anesthesia
• Economic
• Easy to Perform
• High Risk Patient
• Disadvantages
• Local Pain
• Rare Hemorrhage
• Thrombosis (Blood Clot)
• Complications including sepsis, death
• Questionable Value on Grade 3 and 4

9
Laser

• Applicable Grades 1, 2, (3?)
• Percent Success
• 85 - 95 for grades 1 2
• Advantages
• Outpatient
• No Anesthesia
• Economic
• Quick
• Disadvantages
• Some Pain associated
• Bleeding
• Thrombosis
• Questionable efficacy on Higher Grades
• Possible Laser Burn

10
Direct Current

• Applicable Grades
• 1, 2, 3, and 4
• Percent Success
• 85-95 grades 1 thru 3
• Advantages
• Outpatient
• Effective
• Safe (No reported complications)
• Easy to Apply
• No Bowel Preparation
• Applicable to All Grades
• Economic
• No Anesthesia
• Disadvantages
• 8-12 minute procedure vs. 1-5 with Banding
  Laser

11
History of the Technology

• Haynes began using Electrolytic Action to treat
  tissue in 1866
• Baker then actually treated Hemorrhoids with
  Electricity in 1882
• Webb used Electrolysis to destroy tissue in 1921
• Wilbur Keesey used the Direct Current technology,
  referred to as Galvanism, to obliterate
  Hemorrhoids in 1934
• - Developed a crude machine to treat hemorrhoids
• -The machines were cumbersome and difficult to
  use by Physician
• Sources
• Haynes, CM. Electrotherapeutics. W.T. Kenner
  Co., Chicago, 1896, p. 163.
• Webb, JC. Treatment of Hemorrhoids by
  Electrolysis. Br. Med. J. 1921, 1457.
• Ogden, WE. Hemorrhoid Treatment by Galvanism.
  Research Dept., H. G. Fischer Co., Inc.,
  Chicago, 1932.
• Keesey, WE. Obliteration of Hemorrhoids with
  Inverse Galvanism. Am. J. Phys. Ther., May, 1933.
• Keesey, WE. Obliteration of Hemorrhoids with
  Negative Galvanism. Arch. Phys. Ther., 1934
  12533-40.
• Norman, DA. Management of Hemorrhoidal Disease
  An Effective, Safe, and Painless Outpatient
  Approach
• Utilizing D.C. Current. Gastrointestinal
  Endoscopy April, 1987.
• Norman, DA, et.al. Direct Current Electrotherapy
  of Internal Hemorrhoids. Am. J. Gastro. 1989 5
  482-87.

12
Chronology of Events for Ultroid
Why now? Where has the technology been for the
last 10 years?

• 1986 - Ron Newton, Inventor Dr. Dan Norman,
  MD, Gastroenterologist,
• redesigned, improved technology applied for
  patent rights.
• 1987 MicroVasive, Inc. purchased rights,
  filed FDA 510K and began
• marketing the device. Approximately 1,500 units
  sold in first year.
• 1988 MicroVasive transferred Licensing rights
  to Boston Scientific.
• 1994 Cabot Medical obtained technology from
  Boston Scientific.
• 1996 Circon (now ACMI) acquired Cabot and
  displaced Ultroid in attempt to market their
  more expensive Bicap device. Bicap eventually
  was removed from the market due to patient
  complications.
• 2002 Dr. Norman and Mr. Newton eventually
  re-acquired the rights to the technology, updated
  the Ultroid Machine filing a new 510K and
  patents.

13
Ultroid Device

• FDA - 510K filed and approved
• Technology with nearly 20 years of history,
  validation
• Clinical Trials showing high efficacy
• Proven in thousands of cases around the world

14
Mechanism of Action
15
Comparative Study
Good Results Complete Resolution of the
Symptoms Fair Results Marked Improvement in
Symptoms (Amer. Journal of Gastroenterology,
Vol. 84, No. 5, 1989)
16
Comparative Study Conclusion
(American Journal Gastroenterology, Vol. 84, No.
5, 1989 Sheldon S. Zinber, MD, David H. Stern,
MD, Donald S. Furman, MD, Joel M. Wittles, MD)
17
What Doctors are saying about Ultroid

• My patients are very pleased. In fact, they are
  referring family and friends Dr. B. Theobold,
  Missouri
• I had a BAD case of hemorrhoids myself and saw a
  colleague of mine. The experience was so good, I
  am now performing it. Dr. D. Young, South
  Carolina
• I may be one of the first Ultroid users in the
  world. I have been using this device since 1991
  (over 15 years) with unparalleled results. I
  might have treated over 4 thousand patients I
  have not had a single complication and patient
  satisfaction is over 95 or even higher. I can
  not understand, nor believe why this method is
  not the first line of treatment? Dr Joseph
  Georghy, Austrailia

18
What Patients are saying

• My rectal bleeding and itching are totally gone.
  Im very happy. L.B. Brooklyn, NY
• I feel like a new man. D.N. Orlando, FL
• Your treatment has allowed me to avoid a
  surgical operation. E.T. Clermont, FL
• During and after the treatment, I had no pain.
  - Tony, Orlando, FL
• I was a patient of Dr H. in the Salt Lake City
  Utah area.  The treatment was successful and
  exactly as advertised.  Suffice to say I am very
  satisfied. Col. J. T. (Retired)

19
STATISTICS INDICATE YOUR PATIENTS ARE SUFFERING!
HELP THEM WHILE GENERATING SIGNIFICANT
PROCEDURE-BASED INCOME!

• To sign up and reserve your location with Ultroid
  please call
• Gary Schubach, Ed.D, A.C.S.
• 1-415 459-2801
• Email DoctorG_at_DoctorG.com