From sceptic to practitioner: Rediscovery of Physiology First The Alkaline Way to restore enhance or protect health

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From sceptic to practitioner Rediscovery of
Physiology First The Alkaline Way to restore
enhance or protect health
Russell Jaffe, MD, Ph.D., CCN, NACB,FASCP, FACN,
FACAAI, FAMLI, FOCIS, FRSM Fellow, Health Studies
Collegium Director, ELISA/ACT Biotechnologies,
LLC. Director, PERQUE, LLC.
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Personal journey from Submolecular reductionism
to Physiology 1st Principles Alkaline Way
Practices1st stop Occult Blood tests for colon
cancer detection
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Occult Blood as Colon Cancer Screening
test Jaffe RM, Kasten B, Young DS, MacLowry JD.
False-negative stool occult blood tests caused
by ingestion of ascorbic acid (vitamin C). Ann
Intern Med. 1975 Dec83(6)824-826.D.K. w/
unexplained anemia, ascorbic acid ingestion 472
negative stool occult blood tests. Off ascorbic
acid, her stools became strongly reactive ("4")
by 3 tests for occult blood association observed
repeatedly. A new test developed to measure stool
occult blood in the presence of ascorbic acid
remained reactive throughout observation Current
tests for occult blood depend on the
pseudoperoxidase activity of heme are inhibited
by low levels of ascorbic acid. Reducing
substances chemically similar to ascorbic acid
also inhibits occult blood tests oxidized
ascorbic acid and sulfhydryl reducing agents do
not inhibit them at physiologic levels. C D
Griffith, D J Turner, and J H Saunders.
False-negative results of Hemoccult test in
colorectal cancer. Br Med J (Clin Res Ed). 1981
August 15 283(6289) 472
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False negative occult blood tests do not no blood
loss maybe test is wrong. More precise tests are
more sensitive (fewer false positives), specific
(fewer false negatives) predictive(more true
positives).New more sensitive test reduced cost
/ colon cancer detected from 240,000 to 14,000
(1975 )Jaffe R, Zierdt W. An Occult Blood Test
Procedure not Subject to Inhibition by Reducing
Substances. J. Lab. Clin. Med. 1975 93 879-886.
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Personal journey to Physiology 1st The
Alkaline Way2nd stop Collagen cross links
d-penicillamine
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Elastin stretches relaxes like rubber band
Collagen fibrils in extracellular space orient
cells provide bio-architecture matrix
piezoelectric coiled coil
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Science, 2 August 1968 Vol. 161 3840, pp. 475
476 Desmosine Biosynthesis Nature of
Inhibition by D-Penicillamine S. R. Pinnell 1,
G. R. Martin 1, and E. J. Miller 1 National
Institute of Dental Research, Bethesda, Maryland
20014 Administration of D-penicillamine
lathyrogens such as ß-amino-propionitrile
markedly alters connective tissue by preventing
normal cross-linkage of elastin collagen.
ß-aminopropionitrile blocks cross-linkage of
elastin collagen by preventing initial step in
cross-linkage Lysine in peptide linkage converts
to amino adipic-semialdehyde. We show that
penicillamine acts after initial step, causing
accumulation of elastin rich in amino
adipic-semialdehyde. My thesis worked out
d-penicillamines mechanism of action in blocking
elastin collagen cross-links Jaffe R.
Mechanism of Cross-Linkage Inhibition by
Penicillamine, in Texas Reports on Biology and
Medicine, Spring, l971 MSD Awardee.
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Franzblau C, Faris B, Salcedo L, Jaffe R,
Crombie G. Chemistry and Biosynthesis of
Cross-links in Elastin. In Chemistry and
Molecular Biology of the Extracellular Matrix
(Balazas, Ed.) Academic Press, 1970, p 617-641.
Helpful in establishingpulsed d-pen protocolfor
safer toxic metal detection removal from body
15 yearslater
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Franzblau C, Faris B, Salcedo L, Jaffe R,
Crombie G. Chemistry and Biosynthesis of
Cross-links in Elastin. In Chemistry and
Molecular Biology of the Extracellular Matrix
(Balazas, Ed.) Academic Press, 1970, p 617-641.
Helpful in establishingpulsed d-pen protocolfor
safer toxic metal detection removal from body
15 yearslater
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Personal journey to Physiology 1st The
Alkaline Way, 3rd stop Platelet activation by
collagen
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J Clinical Investigation, 1974 53 875-883
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v Worked out How collagen aggregates
platelets 4º action How to block platelet
aggregation    w/ monomeric collagen quaternary
property Quantified number of binding sites
   on platelet for collagen Developed
dose-response platelet aggregation Collaborated
with Fry Mahley of NHLBI   on animal models of
human heart diseasev distress v oxidized
cholesterol or EFAv immune reactions v
vulnerable plaquecholesterol triglycerides
innocent bystanders
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Personal journey to Physiology 1st principles
Alkaline Way, 4th-7th stops Mindfulness,
TCM,Ayurveda, homeopathyremove obstacles to
health
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Bhante Dharmawara 20 years mindfulness,
vipassana buddhology sangha color
healingTCM 7 years with Xing Wu translate
Nan Xing OMSWMPRamamurti Mishra, MD, PhD12
years in Patanjalis sutrasTextbook Yoga
PsychologySelf Awareness, Self Knoweldge Abdul
Aziz Said 20 yearsmindfulness, Sufi
circleJon Young, Tom Brown Regenerative
design, nature wilderness awareness
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Physiology 1st Alkaline Way PFAW

• Health SynthesisUse Physiology
  Pharmacognosybefore PharmacologyRemove
  obstacles to recovery use best benefit / risk
  for what remainsJaffe R, Towsend Letter, January
  2009, p80-89 Diabetes Food Allergy Chapters
  in Food and Nutrients in Disease Management
• Ingrid Kohlstadt (Ed ), CRC Press/Taylor
  Francis Group, 2009, 717 pp, 149.95www.elisaact.
  com/pdfs/EAB_LabComp_Reliability.pdf

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Physiology 1st Alkaline Way PFAW

• Studies to restore health / show sustained
  remissions in diabetes (plt0.01), fibromyalgia
  (plt0.05), Adrenal stress (plt0.001), 50,000 cases
  in database AI result interpretation
• Jaffe R, Towsend Letter, January 2009, p80-89
  Diabetes Food Allergy Chapters in Food and
  Nutrients in Disease Management
• Ingrid Kohlstadt (Ed ), CRC Press/Taylor
  Francis Group, 2009, 717 pp, 149.95www.elisaact.
  com/pdfs/EAB_LabComp_Reliability.pdf

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PsychoNeuroImmunoHormone GV

• Endocrine Neuro- Immune Hormone chemical repai
  r

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Homeostasis Alkaline Way PFAW

• Healthy neuro-immuno-hormone function ample
  capacity to neutralize foreign antigens keeps
  tolerant immune responses
• No Delayed allergy / hypersensitivitiesTolerance,
  better digestion, hydration
• Jaffe R, Mani J, DeVane J, Mani H. Tolerance loss
  in diabetics Association with
• foreign antigen exposure. Diabetic Medicine A
  Journal of the British Diabetic
• Association 2006 Aug23(8) 924-925.

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Use in clinical practice PFAW

• what we eat, drink,
• think do
• determines who we are
• Jaffe, R. Functional Lab Tests to Evaluate Immune
  Competencies in Chronic
• Illness and Chronic Infection Part 1. Townsend
  Letter for Doctors and Patients
• 2006 Jan 87-89 and Part 2 (Feb/Mar) 107-109.

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Eat Ingest, assimilate, eliminate
Foods we can beneficially digest, take up,
utilize excrete without food allergies,
sensitivities or intolerances nutrient dense,
uncontaminated, vine ripened in modified
meso-sino-indo-thai-mediterranean healthy
dietThe Joy of Eating The Alkaline Way, 18th
edition, Health Studies Collegium, Ashburn, VA
20147. Available from EAB (1.800.553.5472) or
PERQUE (1.800.525.7372)
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Eat Calories balanced by activity
Foods we beneficially digest to reverse or
prevent food allergies (RAST, IgE),
sensitivities LRA by ELISA/ACT or intolerances
(lactase deficiency) Organic or biodynamic CSA
or farm market or edible landscape The Joy of
Eating The Alkaline Way, 18th edition, Health
Studies Collegium, Ashburn, VA 20147. Available
from EAB (1.800.553.5472) or PERQUE
(1.800.525.7372)
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Eat Sufficient nutrients to fuel
Antioxidants prevent oxidative stress
inflammatory, repair deficit ills v Ascorbate
calibration (C Flush) v Metabolic acidosis (1st
AM Ur pH) v d-pen (Essential Toxic Minerals) v
Food effects on body chemistry The Joy of Eating
The Alkaline Way, 18th edition, Health Studies
Collegium, Ashburn, VA 20147. Available from EAB
(1.800.553.5472) or PERQUE (1.800.525.7372)
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Eat Alkaline Way Worldwide Health

• Practical guide Identify personalized diet
• Restore tolerance self-regulation
• Reset immune responses
• Body forgives and remembers
• Homeostasis restored
• Once reactive NOT always so
• Program best when followed

Ecological Intelligence by Dan Goleman, Broadway
Books, 2009
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Eat Alkaline Way Worldwide Health

• Practical guide Identify personalized diet
• Restore tolerance self-regulation
• Reset immune responses
• Body forgives and remembers
• Homeostasis restored
• Once reactive NOT always so
• Program best when followed

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Eat source of nutrients wholeness
People dig their graves with their forks. 2,000
year old man, Mel Brooks Of starvation I saw few
die, of over eating a 100,000. Ben Franklin The
Joy of Eating The Alkaline Way, 18th edition,
Health Studies Collegum, Ashburn, VA 20147.
Available from EAB (1.800.553.5472) or PERQUE
(1.800.525.7372)
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Drink source of water minerals

• Drink hard water gt 1 g (1,000 mg)
• dissolved solids (minerals) / liter
• Avoid soft plastic bottles
• Test your water or play roulette
• watertest, 33 Third Street, Suite 102,
  Bordentown, NJ 08505
• Please e-mail your questions to
  customer_service_at_e-watertest.com
• or you can call 609.291.9072 or  800.715.0454

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Drink Test of hydration status
Pinch skin on back of palm, release watch how
quickly skin goes flat. gt1 sec (quick) for
tented skin to go flat at any age, drink 8-12 oz
water repeat in 30 observe.     RussMD.Blog
.com/hydration or www.PERQUE.com or
www.ELISAACT.com
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Think Mental exercises mindfulness

• Use bodys control system NIH GV
• Therapeutic biofeedback (Pat Norris)
• Vipassana or Active Meditation
• (Bhante Dharmawara, Bob Leichtman)
• Mindfulness practices (Howard Zinn, Dan Goleman)
• Evoke human healing responsesKey to all other
  therapys success
• Companionable with all integrative therapies

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Do Exercises, rest recreation

• Move youthfully (Bonnie Pruden)
• Sensation as teacher (Milton Trager)
• Continuous breath
• (Rudy Balentine, Swami Ajaya)
• Breath as refuge light mood modulation (Patanjal
  i, Ramamurti Mishra)
• Core strength, rotation, weight bearingDo the
  movements you enjoy keep moving
• Companionable with all integrative therapies

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Do Exercises, rest recreation

• Move youthfully (Bonnie Pruden)
• Sensation as teacher (Milton Trager)
• Continuous breath
• (Rudy Balentine, Swami Ajaya)
• Breath as refuge light mood modulation (Patanjal
  i, Ramamurti Mishra)
• Core strength, rotation, weight bearingDo the
  movements you enjoy keep moving
• Companionable with all integrative therapies

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Do Exercises, rest recreation

• Move youthfully (Bonnie Pruden)
• Sensation as teacher (Milton Trager)
• Continuous breath
• (Rudy Balentine, Swami Ajaya)
• Breath as refuge light mood modulation (Patanjal
  i, Ramamurti Mishra)
• Core strength, rotation, weight bearingDo the
  movements you enjoy keep moving
• Companionable with all integrative therapies

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Physiology First Alkaline Way PFAW

• Health Enhancement Factors - Erosion Factors
• Helpful good (Nutrition, activity, attitude)
• Nutrition Wholeness adequacy of repair detox
  factors
• Activity Living in harmony with your nature
  and needs
• Mental Attitude Cultivated internal
  equanimitas

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Physiology First Alkaline Way PFAW

• Health Enhancement Factors - Erosion Factors
• Helpful good (Nutrition, activity, attitude)
• Nutrition Wholeness adequacy of repair detox
  factors
• Activity Living in harmony with your nature
  and needs
• Mental Attitude Cultivated internal
  equanimitas - Unhelpful bad (Deficits, toxins,
  distress)
• Deficits Dietary taxes of high tech living
• Toxins Toxic minerals, solvents, biocides,
  pseudoestrogens
• Distress Mental erosion from learned
  anxiety/conflict
• Jaffe R, Morris E. Medicine in Transition, HSC
  report, 1990.

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Physiology First Alkaline Way PFAW

• Health Enhancement Factors - Erosion Factors
• Helpful (Nutrition, activity, attitude)
  Nutrition Nutrient density, variety, and
  sufficient essentials
• Activity Move, stretch, bear weight joyfully
• Attitude Active meditation, internal dialogue

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Physiology First Alkaline Way PFAW

• Health Enhancement Factors - Erosion Factors
• Helpful (Nutrition, activity, attitude)
  Nutrition Nutrient density, variety, and
  sufficient essentials
• Activity Move, stretch, bear weight joyfully
• Attitude Active meditation, internal dialogue
• - Unhelpful (Deficits, toxins, distress)
• Deficits Nutritional borrowing leaves
  overdrafts
• Toxins Pb, Hg, Ar, Ni, Cd, Al,
  chlorinated..., biocides pesticides
  antibiotics pseudoestrogens
• Distress What is and what is ours to change
• Biodetoxification in clinical practice, HSC
  protocol, 1989-2010.

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Physiology First Alkaline Way PFAW

• Loss of Tolerance from toxin, diet deficits,
  stress
• Overload of acquired foreign reactive Antigens
• infectious non-infectious handled
  identically!
• Gel and Coombs (1967) described immune types
• Type 1 Immediate, acute allergy IgE
  RAST
• Type 2 Humoral delayed allergy IgM, IgG, IgA
• Type 3 Immune complex reactions IgM anti-IgG
  Ag
• Type 4 Cell-mediated responses T cells
• Descotes, J, Choquet-Kastylevsky G. Gell and
  Coombs's      
• classification is it still valid? Toxicology,
  2001 158(1-2) 43-49.

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Physiology 1st Alkaline Way PFAW

• Healthy immune function Protective
  homeostatic factors
• Five lines of 1º innate defense No delayed
  allergy / hypersensitivities tolerance
  Re-balance homeostasis
• Jaffe, R. First Line Comprehensive Care. Part II
  Anthropogenic Xenobiotics in
• Functional Medicine. Managing Persisting
  Bioaccumulating Pollutants Toxic
• Minerals, Biocides, Hormone Mimics, Solvents, and
  Chemical Disruptors. Seminars
• in Integrative Medicine 2005 (Sep) 3(3) 79-92.

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Physiology 1st Alkaline Way PFAW

• Healthy immune function includesProtective
  homeostatic digestive factors1. Mucin
  trappers2. Secretory IgA (sIgA)
  binders3. Probiotic microflora
  metabolizers4. Mucosal permeability barrier
  excluders5. Dendritic first responders
  engulfers

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Physiology 1st Alkaline Way PFAW

• Healthy immune function includesProtective
  homeostatic digestive factors1. Mucin
  trappers2. Secretory IgA (sIgA)
  binders3. Probiotic microflora
  metabolizers4. Mucosal permeability barrier
  excluders5. Dendritic first responders
  engulfers

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Physiology 1st Alkaline Way PFAW

• Healthy immune function includesProtective
  homeostatic digestive factors1. Mucin
  trappers2. Secretory IgA (sIgA)
  binders3. Probiotic microflora
  metabolizers4. Mucosal permeability barrier
  excluders5. Dendritic first responders
  engulfers

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Physiology 1st Alkaline Way PFAW

• Healthy immune function protects andyou can
  impact physiology for the better1. Mucin
  trappers2. Secretory IgA (sIgA)
  binders3. Probiotic microflora
  metabolizers4. Mucosal permeability barrier
  excluders5. Dendritic first responders cells
  engulfers

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Physiology 1st Alkaline Way PFAW

• Thrive with 5 alive protocol1. Alkaline
  balance 1st AM Ur pH2. Antioxidants
  Ascorbate calib.3. Relaxation response GSR
  skin temp4. Mucosal permeability Glutamine
  PAK5. Dendritic 1st responders
  Quercetin/OPC info RussMD.Blog or
  1.800.553.5472

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Physiology 1st Alkaline Way PFAW

• Thrive with 5 alive protocol goals1. Alkaline
  balance 1st AM Ur 6.5-7.52. Antioxidants
  Ascorbate 4-100g/d3. Relaxation response Core/P
  TºF 1-1.14. Mucosal integrity Trans Time
  12-18º5. Dendritic 1st responders Phagocytic
  Index info RussMD.Blog or 1.800.553.5472

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Ascorbate needs vary widely
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Physiology 1st Practice Guide

• In Practice
• Identify immune, toxin, neurohormone burden
• Substitute for reactive foods, medications T
  cells, Immune Complexes reactive Antibodies
• Stimulate repair by evoking healing
• Restore tolerance, digestive detox competences
• Achieve sustained remissions
• Personalized, better outcomes by design
• Address / redress causes (not consequences)PERQUE
  Integrative Health, 1.800.525.7372

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Physiology 1st Alkaline Way PFAW

• Health being well Bhante effect
• Immune defense repair as ally or adversary
• Neuro-Immuno-Hormonal control system
• Gain control of control systems!
• Health balance, sufficiency awareness
• Health equation builders - depleters
• Jaffe R, Nash R, Ash R, Schwartz N, Corish R,
  Born T, Lazarus H. Healthcare transparency
  Opportunity or mirage. J Management Development
  2006 25 (10)981-995.

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Bhante effect
The first 40 years, I practiced the abuse of
life, since then, the use of life. which
do you choose?
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Sam Dech Preah Ven Bhante V B Dharmawara
Mahathera Mahatma
Decoded healing systembrought forward by
Buddhabut lost gt1,000 years ago.Green light
meditationGreen dichromatic lightForest and
plant greenSihanook family advisorJarhalal Lal
Nehrus docDhalai Lamas mentor
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Ven Bhante V B Dharmawara Mahathera Mahatma Sam
Dech Preah
Bhante at 109 7 years after full recovery from
stroke 1887 or 1889 - 1999
Ukiah, CA 1996
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Physiology 1st Alkaline Way PFAW

• Immune defense repair system    as ally rather
  than adversary
• Mindbody amplifies perception
• Can recondition responses
• Practice relaxation response or active
  meditationActive Meditation The Western
  Tradition by Robert Leichtman, MD, Ariel Press,
  1976

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Health is matter of balance PFAW

• Live in harmony with our nature
• Know our nature by practice
• Honest communion from nature
• Outcome studies test hypothesis
• Fibromyalgia CFIDS p lt0.01 Diabetes p lt 0.001
  HgbA1c, G/I
• Adrenal p lt 0.005 Cort/DHEA

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www.BetterLabTestsNow.com PFAW

• Free hormone measurement Pl or Sa
• Cortisol / DHEA rhythm
• Adrenaline / Serotonin balance
• FT3, FT4, TSH
• Functional protocols (Self Tests)
• Ascorbate calibration
• 1st AM Urine pH
• Transit time, dehydration test

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Physiology 1st Alkaline Way PFAW
If we are not for ourselves, Who will be for
us? If we are only for ourselves, What are
we? If not now, When? Hillel, 1st
century
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From sceptic to practitioner Rediscovery of
Physiology First The Alkaline Way to restore
enhance or protect health
Russell Jaffe, MD, Ph.D., CCN, NACBFASCP, FACN,
FACAAI, FAMLI, FOCIS, FRCM Fellow, Health Studies
Collegium Director, ELISA/ACT Biotechnologies,
LLC. Director, PERQUE, LLC.
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• Clinical protocols at www.PERQUE.com/protocols
• D-penicillamine provocation 4 essential toxic
  minerals
• 1st AM Urine pH assessment for metabolic
  acidosis
• Digestive Transit Time measurement
• Skin pinch hydration assessment
• LRA by ELISA/ACT in practice
• Ascorbate calibration protocol to counter
  oxidative stress
• Food effects on body chemistry table
• PERQUE Whey Guard for healthy weight management
• Assessing zinc need by taste