GOUT - PowerPoint PPT Presentation

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GOUT

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GOUT A metabolic disease in which tissue deposition of crystals of monosodium urate occurs from supersaturated extracellular fluids and results in one or more ... – PowerPoint PPT presentation

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Title: GOUT


1
GOUT
  • A metabolic disease in which tissue deposition of
    crystals of monosodium urate occurs from
    supersaturated extracellular fluids and results
    in one or more clinical manifestations.
  • These include
  • 1 GOUTY ARTHRITIS
  • Reccurent attacks of severe acute or chronic
    articular or periarticular inflammation
  • 2 GOUT TOPHI
  • accumulation of articular, osseous, soft tissue
    and cartilaginous crystalline deposits
  • 3 GOUTY NEPHROPATHY
  • renal impairment
  • 4 URIC ACID CALCULI
  • in the urinary tract

2
Gout-uric acid
  • Uric acid is the breakdown product of the purine
    residues of nucleid acid
  • Two-thirds is excreted via the kidney and the
    rest via the gut

3
Gout
  • Primary gout
  • Secondary gout
  • -increase dietary intake of purines
  • -overproduction e.g. Myelo- and
    lymphoproliferative disorders
  • -decrease renal excretion in renal failure or
    tubular excretion

4
ACUTE GOUTY ARTHRITIS
  • An acute attack of gout is a dramatic, very
    painful condition
  • typically ache and inflammation in one big toe
  • The joint is
  • swollen,
  • red
  • hot
  • very painful
  • The joint slowly returns to normal
  • often with desquamation and peeling of the
    overlying skin

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ACUTE GOUTY ARTHRITIS-treatment
  • NSAIDs are useful during acute attacks
  • Colchicine
  • Intra-articular steroids

11
CHRONIC TOPHACEOUS GOUT
  • Tophi-small chalky deposits appearing on the
  • ears
  • hands
  • around MTP joints
  • olecranon bursae
  • If the condition is still not treated
  • Gross knobbly swelling develop and may
  • ulcerate
  • become secondarily infected
  • cause severe restriction of
  • movement

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