Title: TREATMENT OF ELDERLY BENZODIAZEPINE - USERS WITH CONTROLLED - RELEASE MELATONIN : IMPROVEMENT OF SLEEP QUALITY
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2SLEEP DISORDERS DRUG THERAPYIN THE
ELDERLY
- INVOLVEMENT OF
- M E L A T O N I N
3 EXOGENOUS MELATONIN Therapeutic Effects
- EXERTS SYNCHRONIZING EFFECTS ON CIRCADIAN
RHYTHMS - IT PHASE ADVANCES SLEEP OF
- PATIENTS SUFFERING FROM
- DELAYED SLEEP- PHASE
SYNDROME - CAN FACILITATE THE POST - FLIGHT
ADAPTATION -
OF JET - LAG - RESYNCHRONIZES THE SLEEP - WAKE CYCLE
-
OF BLIND PEOPLE
4 EXOGENOUS MELATONIN Characteristics
- IS NOT ASSOCIATED WITH
- SERIOUS SIDE EFFECTS
- IS SHORT LIVED IN HUMANS -
- SERUM HALF LIFE IS ONLY 40-50 MINUTES
5 C O N C L U S I O N S
- CONTROLLED - RELEASE MELATONIN
SIGNIFICANTLY IMPROVES SLEEP QUALITY IN
ELDERLY INSOMNIACS - IN WHOM MELATONIN OUTPUT WAS IMPAIRED
- MELATONIN REPLACEMENT THERAPY SHORTENS
SLEEP LATENCY, IMPROVES SLEEP
EFFICIENCY AND DECREASES W.A.S.O.
6 D. GARFINKEL, M. LAUDON, D. NOF, N. ZISAPEL
LANCET 1995 346 541 - 44
- IMPROVEMENT OF SLEEP QUALITY
- IN ELDERLY PEOPLE BY
- CONTROLLED- RELEASE MELATONIN
7 CONCLUSIONS
- CONTROLLED - RELEASE MELATONIN
- CAN FACILITATE BENZODIAZEPINE
DISCONTINUATION OR ENABLES A SIGNIFICANT
DOSE REDUCTION - OF BENZODIAZEPINES,
- WHILE MAINTAINING THE SAME OR BETTER
SLEEP QUALITY
8 FACILITATION OF BENZODIAZEPINE
DISCONTINUATION BY MELATONIN A NEW
CLINICAL APPROACH
D. GARFINKEL, N. ZISAPEL, J. WAINSTEIN, M.
LAUDON, Arch Int Med 159 2456-60, 1999
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