TREATMENT OF ELDERLY BENZODIAZEPINE - USERS WITH CONTROLLED - RELEASE MELATONIN : IMPROVEMENT OF SLEEP QUALITY - PowerPoint PPT Presentation

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TREATMENT OF ELDERLY BENZODIAZEPINE - USERS WITH CONTROLLED - RELEASE MELATONIN : IMPROVEMENT OF SLEEP QUALITY

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title: treatment of elderly benzodiazepine - users with controlled - release melatonin : improvement of sleep quality author: doron – PowerPoint PPT presentation

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Title: TREATMENT OF ELDERLY BENZODIAZEPINE - USERS WITH CONTROLLED - RELEASE MELATONIN : IMPROVEMENT OF SLEEP QUALITY


1
???? ?????? ?? ?????? ?????? ???????
??????? ???? ?????? ???? ???? ?????? ??????
???????????? ????? ????? ?? ????? ???????? -
?????? ??? ??????? ? ?
????? ????? ???? ?? ????? ?????? ?????? ???????
????? ???? ?? ?? ?????-???????
2
SLEEP DISORDERS DRUG THERAPYIN THE
ELDERLY
  • INVOLVEMENT OF
  • M E L A T O N I N

3
EXOGENOUS MELATONIN Therapeutic Effects
  • EXERTS SYNCHRONIZING EFFECTS ON CIRCADIAN
    RHYTHMS - IT PHASE ADVANCES SLEEP OF
  • PATIENTS SUFFERING FROM
  • DELAYED SLEEP- PHASE
    SYNDROME
  • CAN FACILITATE THE POST - FLIGHT
    ADAPTATION

  • OF JET - LAG
  • RESYNCHRONIZES THE SLEEP - WAKE CYCLE

  • OF BLIND PEOPLE

4
EXOGENOUS MELATONIN Characteristics
  • IS NOT ASSOCIATED WITH
  • SERIOUS SIDE EFFECTS
  • IS SHORT LIVED IN HUMANS -
  • SERUM HALF LIFE IS ONLY 40-50 MINUTES

5
C O N C L U S I O N S
  • CONTROLLED - RELEASE MELATONIN
    SIGNIFICANTLY IMPROVES SLEEP QUALITY IN
    ELDERLY INSOMNIACS
  • IN WHOM MELATONIN OUTPUT WAS IMPAIRED
  • MELATONIN REPLACEMENT THERAPY SHORTENS
    SLEEP LATENCY, IMPROVES SLEEP
    EFFICIENCY AND DECREASES W.A.S.O.

6
D. GARFINKEL, M. LAUDON, D. NOF, N. ZISAPEL
LANCET 1995 346 541 - 44
  • IMPROVEMENT OF SLEEP QUALITY
  • IN ELDERLY PEOPLE BY
  • CONTROLLED- RELEASE MELATONIN

7
CONCLUSIONS
  • CONTROLLED - RELEASE MELATONIN
  • CAN FACILITATE BENZODIAZEPINE
    DISCONTINUATION OR ENABLES A SIGNIFICANT
    DOSE REDUCTION
  • OF BENZODIAZEPINES,
  • WHILE MAINTAINING THE SAME OR BETTER
    SLEEP QUALITY

8

FACILITATION OF BENZODIAZEPINE
DISCONTINUATION BY MELATONIN A NEW
CLINICAL APPROACH
D. GARFINKEL, N. ZISAPEL, J. WAINSTEIN, M.
LAUDON, Arch Int Med 159 2456-60, 1999
9
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