Title: ??????:????????? Pharmacy Practice Skills: Drug-Related Problems Solving
1???????????????Pharmacy Practice Skills
Drug-Related Problems Solving
2????
- ?? systematic clinical drug monitoring ???????
- ?? SOAPing format ??????????????
- ?? patient case presentation ??????
- ??? SOAPing format ???????????
- ?????,?????????????
- -???????,????
3Systematic Clinical Drug Monitoring????
- The responsibility of a pharmacist to provide
services in a consistent and complete manner - The complexity of a patients health problems
- The comprehensible communication among health
care professionals
4The Purposes of Systematic Clinical Drug
Monitoring
- Determine that all of a patients drug therapy is
the most appropriate, most effective, safest, and
most convenient available. - Identify any drug therapy problems (DTPs DRPs)
and the goal of therapy. - Identify any drug therapy problems (DTPs) the
patient is at risk of developing in the future?
that is to say, any drug therapy problems the
pharmacist must help the patient to prevent in
the future
5Pharmaceutical Care Process
6Problem-Oriented Approach
- In 1964, Lawrence E Weed published the
problem-oriented approach to medical records,
patient care, and medical education. - A systematic, disciplined approach to each
patient is used - No important therapeutic considerations are
missed
7Problem-Oriented Approach
- Two main components
- Complete problem list
- Physical
- Psychological
- Social/financial
- SOAP notes
- Logical thinking process
- ???????, ????????
- One visit one SOAP
8POMRProblem Oriented Medical Record
- Dr. Lawrence Weed ???????????
- POMR Problem List (? x ?) ?? SOAP
- Problem 1 SOAP 1
- Problem 2 SOAP 2
-
- Modified SOAP
- S
- O
- A (Problem 1, 2, )
- P (Problem 1, 2, )
9????
- ????
- ???????
- Patient Case Presentation
- From database to plan
- 1. From data base to assessment (SOAP notes)
- 2. Assessment
- 3. From assessment to plan (Implentation)
- SOAPing format
- ????
- Daily SOAP note
- Oral case presentation
10??????
11????????-????
- ????
- ?????-????
- ??????(????, ??, ??, workbook,
pharmacotherapy?????) - Disease Management Case Demo (ASHPs PharmPrep
2001) - Terry L. Schwinghammer pharmacotherapy Casebook
6th Ed. - ????
- ???? (10????)
- ?????,????
- 1. ???? 2??
- 2. ???? 1??
- 3. ?????? SOAPing format???
- (2??/?, ? 5-6?)
12???????
13???????
14????
- ???? (Discharge summary)
- ??? (?? / ?? -TPN ? C/T)
- TPR sheet
- Admission note (????? / ??????????)
- Progress note (SOAP format)
- ????
- ????? (X-ray, Cath, RT)
- ???? (Lab data)
- ??????? (GCS, APACHE II scale)
- ??????? / ???????
- ????
- ????
- ?????/ ????
- ?????? ????? / ???????
15Medication Administration Record(MAR)
- Routine or maitenance
- Antibiotics, anticonvulsants
- P.R.N.
- Usually are listed at the end of the MAR
- Fever (if gt38.5?)
- Pain medication
- Antiemetics
- Sedative-hypnotic agents
- Stat (Statim, immediately)
- Administered once and not repeated unless
recorded - Given as soon as possible
- Prescribed in life-threatening or emergency
situations - One time order
- Given as soon as convenient and sometimes can be
scheduled ahead of time - C/T
16???? Progress Note
- ??
- ?????????????????????
- ??-????, ??(??), ????, ??????
- ???
- ????????,?????,?????,?????????????
- ?????,??????,??????????
- ?????,??????????,???????????????????????
- ?????,????????,??????????,??????????
- ?????,??????????,?????????
- ??-SOAP format
17????
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18???? (??)
- ???????? (??? ??)
- ??????
- ?, ?, ?, ?, ??, ??
- ????, ????, ??, ????
- ???????????? (??? ??)
- ?????? (primary care training)
- ?? (??????, ????????????)
- ?? (CV, GI, Nephro, Chest, Endo, Neuro, Rheuma,
- ID, Hema, Oncology)
- The Washington Manual of Medical Therapeutics
31ed. - Clinical skills for pharmacists, A
patient-focused approach. 2nd Ed. Karen J.
Tietze, Mosby
19- Patient Case Presentation
The accepted tool for documenting and
communicating patient information (suggested by
Tietze, K.J.)
20Components of the Patient Case Presentation
- General information
- Chief complaint (CC)
- History of present illness (HPI)
- Past medical history (PMH)
- Medication history (MedHx)
- Family history (FH)
- Social history (SH)
- Review of systems (ROS)
- Physical examination (PE)
- Pertinent positive and negative laboratory and
diagnostic test results (Labs) - Pt problem list and initial plans
- Pt progress
- Discharge data
- Final diagnosis
- Discharge medications
- Plans for follow-up
21Suggested Sequence for Presentation of Information
- ?
- Review of systems (ROS)
- ?
- Physical examination (PE)
- ?
- Laboratory and diagnostic test results (Lab)
- ?
- Problem list and initial plans
- (SOAP format)
- ?
- Pt progress to date
- (SOAP format)
- General information (Gen)
- ?
- Chief complaint (CC)
- ?
- History of present illness (HPI)
- ?
- Past medical history (PMH)
- ?
- Social history (SH)
- ?
- Family history (FH)
- ?
- Medication history (MedHx)
- ?
22From database to plan
Steps of Systematic Clinical Drug
Monitoring (suggested by Shao C, Chiang,
Pharm.D., R.Ph.)
23Problem Conversion
- Medical problems (Dx)
- Medication problems
- (Drug therapy problems )
24From Database to Plan
- 1.From data base to assessment
- SOAP notes
- 2.Assessment
- 3.From assessment to plan (Implentation)
- Therapeutics planning-pharmacist
- Diagnostic
- Therapeutic (Prescription)
- Educational (pt)
- Monitoring
251.From data base to assessment (SOAP notes)
At admission (new pt)
26SOAPing
Database
CC HPI PMH FH SH Med Hx Compliance Allergies ROS PE Lab tests X-ray Scans Procedure SOAP notes
Problem list
numbered acuity/priority Resolved / inactive
SOAP notes
Implementation of plan
diagnostic therapeutic educational (pt)
Follow-up of progress
272. Assessment
At admission (new pt)
28Interpret the Findings in Terms of the Probable
Process
- Pathological process
- Congenital / Inflammatory
- Immunological / Neoplastic
- Metabolic / Nutritional
- Degenerative / Vascular
- Traumatic / Toxic
- Pathophysiological
- Psychopathophysiological
- Drug-related
29Make One or More Hypotheses about the Nature of
the Patients Problem
- Select the most specific and central findings
around which to construct your hypothesis. - Match your findings against all the conditions
you know that can produce them. - Eliminate the diagnostic possibilities that fail
to explain the findings. - Weigh the competing possibilities and select the
most likely diagnosis from among the conditions
that might be responsible for the patients
findings - Give special attention to potentially
life-threatening and treatable conditions
303.From assessment to plan (Implentation)
Therapeutics planning
At admission (new pt)
31Components of Therapeutics Planning
Regimens- initial alternative
32The Planning Process
- Problem identification
- Identification of subjective and objective
parameters - Grouping of related parameters
- Assessment of the parameters and determination of
specific pt problems - Problem prioritization Identify active and acute
problems - Selection of specific therapeutic regimens
- Creation of a list of therapeutic options
- Elimination of drugs from the list based on
pt-specific and external factors - Selection of dosage, route, and duration of
therapy - Identification of alternative therapeutic
regimens - Creation of a monitoring plan
- Monitoring and modification of the regimens as
necessary
33Common Subjective Parameters
Anxiety Bloating Blood-tinged sputum Blurred vision Breast tenderness Chills Cold intolerance Confusion Constipation Cramps Decreased appetite Depression Diarrhea Difficulty concentrating Dry skin Dysuria Fatigue Flatulence Headache Heartburn Heat intolerance Impotence Indigestion Insomnia Itching Joint pain Loss of appetite Loss of libido Muscle aches Muscle weakness Nasal congestion Nasal itching Nausea Nervousness Numbness Pain Palpitations Pounding pulse Rash Seizures Shortness of breath Slurred speech Sneezing Sore throat Syncope Thirst Tingling Tinnitus Tremor Vertigo Weakness Wheezing
34Common Objective Parameters
BH and BW Vital signs BT, BP, HR, RR Blood chemistries Na, K , Cl, CO2, Glu, Scr, AST, ALT, Bil, Ca, Mg, CHL, TG, Alk-P, LDH, UA, BUN Blood gases pH, Pco2, Pco2, HCO3- Blood protein Total protein, albumin, complements, immunoglobulins Hematolog Hb, Hct, MCV, MCH, MCHC, RBC, WBC DC Urinalysis Sp. gr, cellular content, protein Cultures and sensitivites Blood, urine, sputum, tissue Serum blood concentrations Specific organ system tests PEFR, FEV1, FVC , FEV1/FVC, EF, T3, T4, TSH, Clcr Miscellaneous U/O, abd girth, no. of loose stools/day, I/O
35Factors to Consider when Selecting a Specific
Therapeutic Regimen
- Patient-specific factors
- What regimens have effectively managed the
problem in the past? - What regimens have not effectively managed the
problem in the past? - How might other patient problems influence the
proposed regimen? - How might the proposed regimen influence other
patient problems? - External factors
- Current state of the art therapeutics
- Cost of the proposed therapv
- Formulary limitations
36Guidelines for Altering Initial Drug Therapy
- If the regimen is ineffective, change the drug if
the following are true - The patient received an adequate trial of the
drug - The patient received an adequate dosage of the
drug - The patient is compliant
- If the regimen is associated with
life-threatening side effects, discontinue the
drug - If the patient is not complying with regimen
because of unacceptable side effects, discontinue
the drug - If the patient has non-life-threatening side
effects and is willing to continue the drug, - minimize the side effects by doing the following
- Adjust the dosage of the drug
- Change the timing of the dose
373.From assessment to plan (Implentation)
Monitoring
At admission (new pt)
38Patient-Focused Care Cycle A Never-Ending Cycle
39The Process of Monitoring Therapeutic Regimens
- Set therapeutic goals
- Determine patient- and drug-specific monitoring
parameters - Integrate the monitoring plan
- Obtain data
- Assess the response to therapy
- Alter the therapeutic regimen if necessary
- Repeat Step 1-6
40Organization of Monitoring Parameters (The
Four-Square Method)
Subjective-Therapeutic Subjective-Toxic
expected therapeutic outcome indicating therapeutic failure or harm
Objective-Therapeutic Objective-Toxic
expected therapeutic outcome indicating therapeutic failure or harm
41Steps of systematic clinical drug monitoring at
inpatient setting
Hospital stay (old pt)
42Hospital Stay
- Daily SOAP note
- Each problem has its own SOAP note.
- The subjective and objective data should include
the values of drug monitoring parameters. - All problems should be assessed and planed,
unless the problem has been resolved - Daily drug monitoring
43Real Practice Setting
- With time and practice, the process of assessing
patient therapy and prioritizing the need to make
an intervention becomes second nature and does
not require a concerted effort to mentally check
off each step after it has been performed. - Setting priority about which patients require
more in-depth intervention.
44SOAPing format
45SOAPing Format
- SOAPing
- The process of identifying the subjective and
objective data, assessing the problem, and
developing a specific therapeutic and monitoring
plan - A formal organizationl structure
- Steps
- Creation of a list of related subjective
parameters - Creation of a list of related objective
parameters - Assessment and documentation of the problem
- Documentation of the therapeutic plan for
addressing the problem
46Thinking Process Tips
- Problem identification
- Desired outcome
- Therapeutic alternatives
- Optimal plan
- Outcome evaluation
- Patient education
47Problem List
Current medical problems Goal of therapy Measurable endpoint
48SOAPing FormatUSC School of Pharmacy Kathleen
Besinque Pharm D, MS Ed.)
49Current Drug-Therapy Problems
Subjective and Objective Subjective and Objective
Problem(subjective and objective) Current medication
S CC Pertinent medical Hx(HPI / PMH) ROS SH FH Allergies ADR Drugs OTCs Herbal
O (PE /Labs) Drugs OTCs Herbal
50Current Drug-Therapy Problems
Assessment Assessment
Etiology (or risk factors) Evaluate need for therapy evaluate current therapy (Evidence need for therapy evaluation)
Drug therapy problem 1 CPG1 Class of drugs
Drug therapy problem 2 CPG2 Class of drugs
Drug therapy problem 3 CGP3 Class of drugs
51Current Drug-Therapy Problems
Plan Plan Plan
Recommended drug treatment, drug to be revised, further test Goal and monitoring parameters (toxic and therapeutic) Patient education
Recommend 1 Item of drugs Goal 1 Therapeutic Toxic Education 1
Recommend 2 Item of drugs Goal 2 Therapeutic Toxic Education 2
Recommend 3 Item of drugs Goal 3 Therapeutic Toxic Education 3
52Problem Conversion
- Medical problems (Dx)
- Medication problems
- (Drug therapy problems)
53???????????
54??????????? (1)
- ???? clinical drug monitoring ? case presentation
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- ??????? (????)????????
- Medical problem (Dx) Medication problems
-
(Drug therapy problems) - ?????????????daily SOAP note
- ????????
- ???????????
55??????????? (2)
- ????????????????
- ????????????????
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- ?????????Drug therapy problems
- ??????
- ?????????, ????Drug therapy problems???
- ???????? / ??????????
- ????? concurrent case
- ????????
- ???????????
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56??
- Problem oriented drug monitoring
- ????????
- ??????Drug therapy problems
- ??????????
- ?????????
- ????/???????-???
57Case Example(????)Hypertension
58????(HTN)
- Establish goals for the treatment of HTN.
- Choose appropriate lifestyle modifications and
anti-HTN based on patient-specific characteristis
and concurrent disease states. - Design appropriate monitoring plans for pts
receiving anti-HTN therapy, including laboratory
parameters and time intervals. - Modify pharmacotherapeutic regimens for pts who
experience adverse events or do not have adequate
BP reduction on an initial regimen. - Provide appropriate patient education for
anti-HTN regimens.
59Patient General Information (Gen)??????
Patient name ??? Patient name ???
Chart no xxxxxxxx (Bed no xxxx-x) Chart no xxxxxxxx (Bed no xxxx-x)
Address ?????? Address ??????
Age 79 Height 175 cm
Sex M Marriage status married
Weight 95.4kg Allergies NKDA
Date of admission (DOA) yy mm dd Date of admission (DOA) yy mm dd
60Chief Complaint (CC)??????
- ??? is 79-yo male seen in the ED with respiratory
distress with severe dyspnea and wheezing.
61History of Present Illness (HPI)?????????
- ??? was coming home from the grocery store when
he became short of breath and wheezing carrying
in his groceries. - He could only say a couple words between breaths.
His neighbor noticed him in distress and called
911. - ??? experienced severe shortness of breath 6
months ago and was hospitalized for acute severe
asthma.
62Past Medical History (PMH)????
- Diagnosis with asthma approximately 20 years ago,
rheumatoid arthritis about 5 years ago, and
benign prostatic hyperplasia last year. - Patient using a herbal product to treat his
benign prostatic hyperplasia. - Admitted to hospital 3 times in the past 2 years
for exacerbation of asthma. - Previous office visit 5 weeks ago, documented a
blood pressure reading of 150/95 mmHg.
63Social History (SH)?????
- Tobacco use 1/2 pack/week
- Alcohol use Six pack per week
- Caffeine use 2 Cups of coffee every morning
64Family History (FH)????
- Mother died of an MI at age 68.
- Father died of lung cancer at age 75.
65Medication Record (Prescription and OTC)
(MedHx)???
- Furosemide 40 mg po q AM
- Albuterol inhaler 2 puffs qid prn
- Beclomethasone inhaler 1 puff qid
- Ibuprofen 800 mg po tid
- Herbal product with licorice po qd
- Acetaminophen po prn
66Review of Systems (ROS)??????? (HPI ??)
67Physical Examination (PE)????
- VS
- BP 160/100 mmHg
- HR 120 beats/min
- RR 31 rpm
- T 38.5?
- Ht 175 cm
- BW 95.4 kg
- BMI 31.2 (95.4/1.75x1.75)
- CHEST Expiratory wheezes
68Laboratory and Diagnostic Tests (Labs)?????????
Potassium 3.8 mEq/L Sodium 145 mEq/L Serum creatinine 1 mg/dL
FBG 100 mg/dL Total cholesterol 200 mg/dL HDL 35 mg/dL
RBC 4.7 cells/mm3 Hgb 15 g/dL Hct 44
PH 7.40 PaO2 55 mmHg PaCO2 40 mmHg
69Diagnosis??
- Primary
- 1)Asthma
- 2)Hypertension
- Secondary
- 1)Benign prostatic hyperplasia
- 2)Rheumatoid arthritis
- Problem list
70Problem List
Current medical problems Goal of therapy Measurable endpoint
Primary 1)Asthma Symptom control Prevent asthma episodes or attacks PEFR No DOE, SOB, PND
2)Hypertension Prevent CHD, Stroke and Nephropathy BP
Secondary 1)BPH Symptom control DRE (digital rectal exam) UFR (urine flow rate)
2)RA Improve QOL Arrest or retard disease progress Swollen tender joints RF, ESR, ANA, CBC X-Ray
71Current Drug-Therapy Problems
Subjective and Objective Subjective and Objective
Problem(subjective and objective) Current medication
S Pertinent medical HxAsthma x 20 yrs RA x 5 yrs BPH x 1yr ago HTN x 5wks ROS respiratory distress with severe dyspnea wheezing and coughing Tobacco use 0.5 pack/week alcohol use 6 pack / week caffeine use 2 cups of coffee every morning Use a herbal product to treat his BPH Furosemide 40 mg po q AM Albuterol inhaler 2 puffs qid prn Beclomethasone inhaler 1 puff qid Ibuprofen 800 mg po tid Herbal product with licorice po qd Acetaminophen po prn
O 175cm , 95.4kg HR120 BP160/100 RR31 T38.5? Expiratory wheezes PH 7.40 PaO2 55 PaCO2 40 Admitted to hospital 3 times/past 2 yrs for AE of asthma BP 150/95 mmHg previous office visit 5 wks ago Furosemide 40 mg po q AM Albuterol inhaler 2 puffs qid prn Beclomethasone inhaler 1 puff qid Ibuprofen 800 mg po tid Herbal product with licorice po qd Acetaminophen po prn
72Current Drug-Therapy Problems
Assessment Assessment
Etiology (or risk factors) Evaluate need for therapy evaluate current therapy (Evidence need for therapy evaluation)
AE of asthma Primary therapies for AE (most safely undertaken in a hospital or hospital-based ER) Repetitive administration of rapid-acting inhaled ß2-agonist Early introduction of systemic glucocorticosteroids Oxygen supplementation Closely monitor response to treatment with serial measures of lung function
Inadequate response to treatment for HTN D/C herbal product with licorice ( has been shown to have an aldosterone-like action) Both ibuprofen and licorice can cause an inadequate response to HTN therapy If BP remains elevated, the clinician should consider initiating ana-blocker
Inadequate BPH treatment The preferred therapy for this pt may be a-blockers (the favorable effects on prostatism and dyslipidemia-decrease LDL-C and increase HDL-C Postural hypotension is commonly experienced witha-1 blockers because of the direct action The first-dose phenomenon is characterized by transient dizziness,faintness, palpitations, and syncopy occurring within 3 hrs of the first dose.
73Current Drug-Therapy Problems
Plan Plan Plan
Recommended drug treatment, drug to be revised, further test Goal and monitoring parameters (toxic and therapeutic) Patient education
IV methylprednisolone 60-80 mg or Hydrocortisone 300-400 mg or oral prednisolone 0.5-1 mg/kg for 7-10 days Decrease symptom PEFR (GINA 2004) Report any ? in SOB, DOE, PND Techniques in use of medications Smoking cessation
D/C herbal product with licorice BP check daily BP in 1wk lt 140/ 90 (JNC VIII) Teach pt how to self measurement of BP Remind pt that home measurement device should be checked regularly for accuracy Lifestyle modification recommendations (5 modifications)
Usual dose Prazosin 2-30 mg ,bid-tid Terazosin 1-20 mg ,qd-bid Doxazosin 1-16mg ,qd (first dose at hs) Decrease symptom (bladder outlet obstruction, postvoid residual urine volume, reverse urinary retention / RI May be avoided by having the pt take the first dose and/or the first increase in dose at bedtime
74???? ????
?? Un Clos (A Close)-?? Cezanne 1890
75????
- 920 1050 ???????
- 1050 1200 ??????
- ????? 1050 1100 Type 2 DM--initiate OADs in
a newly diagnosed DM patients - ????? 1100 1110 Hypertension--inappropriate
drug of choice and inadequate BP control for HTN - ????? 1110 1120 Hyperlipidemia--initiate
lipid lowing agents for a patient with high CV
risks - ????? 1120 1130 Obesity, metabolic
syndrome--pharmacotherapy of obesity and
metabolic syndrome - ????? 1130 1140 ?????????
- ????? 1140 1150 SOAP??????
- 1150 1200 ?????
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