Session III: Linking Intermacs to the World: The Power of Collaboration Intermacs and the ISHLT Registry for Mechanically Assisted Circulatory Support (IMACS)

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Session III Linking Intermacs to the World The
Power of CollaborationIntermacs and the ISHLT
Registry for Mechanically Assisted Circulatory
Support (IMACS)
Rongbing Xie, MPH IMACS Statistician
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Outline

• IMACS Overview
• Collaboration with INTERMACS
• IMACS Research
• Collaborative Benefits/Challenges
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IMACS Overview

• The International Society for Heart and Lung
  Transplantation Registry for Mechanically
  Assisted Circulatory Support (IMACS)
• International registry
• Enrolls and follows durable MCSD patients
• Global collaboration
• Research
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IMACS Steering Committee
U.S.A. James K. Kirklin, MD Craig Collum, MPH Rongbing Xie, MPH Ryan Cantor, MSPH Josef Stehlik, MD, MPH Robert L. Kormos, MD Francisco Arabia, MD Daniel J. Goldstein, MD Jennifer Cowger, MD Stephen Schueler, MD, PhD, FRCS Ulrich P. Jorde, MD Amanda W. Rowe Mandeep R. Mehra, MD, MBBS, FACC, FACP Australia Chris J. Merry, MD Canada Anne I. Dipchand, MD Singapore Cumara C. Sivathasan, MBBS, FRCS U.K. Stephen Schueler, MD, PhD, FRCS Germany Theo De By, BA, MBA Ireland Margaret M. Hannan, MD Sweden Lars H. Lund, MD, PhD Japan Takeshi Nakatani, MD, PhD
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IMACS Organizational Chart
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IMACS Enrollment Update
as of 3/2/16 as of 3/2/16
Total Number of Individual Hospitals Enrolled 20
Total Number of Collectives Enrolled 4
Total number of Adult Patients Enrolled (Individual and Collective combined) 9650
Total Number of Countries Represented in the IMACS Registry 31
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INTERMACS Contributions to IMACS

• Patient volume (76 IMACS patients)
• Longer observational periods
• Years of experience with data collection,
  management, reporting, and research
• Recognition, validity, and assurance
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INTERMACS Engagement in IMACS

• Administrative
• Serve on executive committee
• Participate at ISHLT annual meeting
• Assist with hospital recruitment
• Data Collection
• Data agreement, sharing and linking
• Research
• Research committee
• Annual report
• Publications
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IMACS Publications

• The dawn of the ISHLT Mechanically Assisted
  Circulatory Support (IMACS ) Registry
  Fulfilling our missionThe Journal of Heart and
  Lung Transplantation. 2012 Feb 31(2)
  115-116Percutaneous drive-line infections into
  the future with the International Mechanically
  Assisted Circulatory Support (IMACS)
  RegistryThe Journal of Heart and Lung
  Transplantation. 2012 Nov 31 (11) 1149-1150
• First Annual IMACS Report A Global ISHLT
  Registry for Mechanical Circulatory SupportThe
  Journal of Heart and Lung Transplantation.
  Article In Press
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Annual Report
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Highlights from IMACS First Annual Report
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Risk Factors for IMACS Adult Patients Survival

• Early Phase Risk Factors
• Older Age
• Female
• INTERMACS Profile 1
• Non-Continuous Flow Devices
• Surgical complexities (History of CABG,
  Concomitant surgery)
• Dialysis at Implant
• RVAD in the same operation
• Constant Phase Risk Factors
• Prior Stroke
• Severe RVEF impairment
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Collaborative Benefits/Challenges

• Benefits
• Hospitals and collectives quality assurance
• Physicians practice standards
• Patients quality of care
• Challenges
• Time-zones
• Data management timelines
• Recruitment
• Regulatory
• Language
• Definitions and measurements
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Thank You
Website https//www.ishlt.org/registries/mcsdData
base.asp Email imacs_at_uab.edu