Muscle and nerve physiology

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Neuromuscular transmission
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Motor Unit

• Motor Unit
• is the motor neuron
• and all the muscle
• fibers it supplies
• all of these fibers will have the same type
  (either fast twitch or slow twitch). When a motor
  unit is activated

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The Neuromuscular junction consists of

• Axon Terminal contains
• around 300,000 vesicles which contain the
  neurotransmitter acetylcholine (Ach).
• Synaptic Cleft
• 20 30 nm ( nanometers ) space
• between the axon terminal the
• muscle cell membrane. It contains
• the enzyme cholinesterase which
• can destroy Ach .

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Synaptic transmission

• Synapse is the junction between two neurones
  where electrical activity of one neurone is
  transmitted to the other

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Acetylcholine (1)

• Ach is synthesized locally in the cytoplasm of
  the nerve terminal, from active acetate
  (acetylcoenzyme A) and choline.
• Then it is rapidly absorbed into the synaptic
  vesicles and stored there.
• The synaptic vesicles themselves are made by the
  Golgi Apparatus in the nerve soma ( cell-body).
• Then they are carried by Axoplasmic Transport to
  the nerve terminal , which contains around
  300,000 vesicles .
• Each vesicle is then filled with around 10,000
  Ach molecules .

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Steps involved

• AP at the synaptic knob ----- Ca channels open
  (increase Ca permeability) -----
• release of neurotransmitter (NT) from synaptic
  knob to synaptic cleft -----
• NT combines with specific receptors on the other
  membrane ----- postsynaptic potential ----- AP
  will result

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Neuromuscular transmission
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Neuromuscular transmission

• Transmission of impulse from nerve to muscle
  (neuromuscular junction)
• Steps
• AP at nerve knob ----- increase Ca permeability
  (Ca inter synaptic knob) ----- release of
  Acetylcholine (Ach) ----- Ach combine with
  receptors on motor end plate ----- Na
  permeability increase ----- end plate potential
  develop ----- AP spread on the membrane -----
  muscle contraction

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Myasthenia gravis

•  autoimmuneneuromuscular disease 
• Muscle weakness
• Due to circulating antibodies that
  block acetylcholine receptors at the
  postsynaptic neuromuscular junction
• Leading to fluctuating muscle weakness
  and fatigue.

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• Acetylcholinesterase inhibitors 
• neostigmine

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Curare

• Arrow poisons
•  competitively and reversibly inhibiting
  Acetylcholine receptors found at
  the neuromuscular junction
• Anesthesia

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