Efector functions of CD4 and CD8 T-cells

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Efector functions of CD4 and CD8 T-cells
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Defense- intracellular pathogens, stimulation of
IgG production
Organ-specific autoimmune diseases
Defense- helmints
Allergy
Defense- extracellular bacteria, fungi
Autoimmunity and chronic inflammation
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Macrofage activation B-cells
IFN-?
IL-12
T-bet
IL-4 IL-5 IL-13
Eosinophil activation B-cells
IL-4
GATA-3
Neutrophil activation...
IL-17 IL-22
IL-23
RORgt
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TH1 response
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• Efector functions of TH1 cells
• Macrophage activation at the site of infection

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• Efector functions of TH1 cells
• Macrophage activation at the site of infection

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• Efector functions of TH1 cells
• Macrophage activation at the site of infection

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• Efector functions of TH1 cells
• Macrophage activation at the site of infection

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• Efector functions of TH1 cells
• Macrophage activation at the site of infection

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• Efector functions of TH1 cells
• Macrophage activation at the site of infection

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• Efector functions of TH1 cells
• B-cell activation

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Defense- intracellular pathogens, stimulation of
IgG production
Organ-specific autoimmune diseases
Defense- helmints
Allergy
Defense- extracellular bacteria, fungi
Autoimmunity and chronic inflammation
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TH2 response
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Defense- intracellular pathogens, stimulation of
IgG production
Organ-specific autoimmune diseases
Defense- helmints
Allergy
Defense- extracellular bacteria, fungi
Autoimmunity and chronic inflammation
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TH17 response
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Defense- intracellular pathogens, stimulation of
IgG production
Organ-specific autoimmune diseases
Defense- helmints
Allergy
Defense- extracellular bacteria, fungi
Autoimmunity and chronic inflammation
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CTL effector function
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Mechanisms of CD8 T-cell cytotoxicity
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Mechanisms of CD8 T-cell cytotoxicity
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Mechanisms of CD8 T-cell cytotoxicity
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Mechanisms of CD8 T-cell cytotoxicity
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Mechanisms of CD8 T-cell cytotoxicity
Target cell
CD8 CTL
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Mechanisms of CD8 T-cell cytotoxicity
perforin
Target cell
CD8 CTL
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Mechanisms of CD8 T-cell cytotoxicity
perforin
granzimi
Target cell
CD8 CTL
apoptosis
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Mechanisms of CD8 T-cell cytotoxicity
Target cell
CD8 CTL
FasL
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Mechanisms of CD8 T-cell cytotoxicity
Ciljna celija
CD8 CTL
apoptosis
FasL
Fas
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Pathogens avoid cellular immunity
Inhibition of fusion of phagosome with lysosome
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Inhibition of presentation of viral antigens
0
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Inhibition of immune response by virokines and
viroreceptors
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production of IL-4, IL-5, IL-13
a.
Subpopulations of efektor CD4 T-cells are
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Inflammatory reaction rich in eosinophils
b.
TH1 effector function is
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helminats
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TH1 cells are important for defense against
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TH1, TH2 i TH17
d.
TH2 effector function is
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alternative macrophage activation
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TH2 cells are important for defense against
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mobilises and activates neutrophils
f.
TH2 subpopulation induces
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IFN-? production and macrophage activation
g.
IL-4 and IL-13 induce also
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intracellular pathogens
h.
IL-17
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perforin, granzymes, Fas-FasL interaction
i.
CTL effector function is
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killing virus-infected and tumor cells
j.
CTL killing mechanisms are
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