BIOMEDICA LIFE SCIENCES SA

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BIOMEDICA LIFE SCIENCES SA

• Expanding a commercial SME
• specializing in radiopharmaceuticals and
• high-tech medical imaging instrumentation
• into a dynamic group of Biotechnology companies

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BIOMEDICA LIFE SCIENCES SAEstablished in
1994Total number of employees 29 2003 revenue
from sales 4,016 mil EBT 0,9 mil
Main concept for the expansion

• Coupling BIOMEDICAs management and marketing
  resources and expertise
• with
• excellence in biotechnological research
• of Greek Research Institutes and University
  Laboratories

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Strategy Main Points and Objectives

• 1. Establishing the companys RD base through
  the collaboration with research groups in
  National Research Centres and Universities
• 2. Organizing and managing a state-of-the-art
  Radiopharmaceuticals Production Unit (GMP) based
  on the infrastructure and know-how of NCSR
  Demokritos
• 3. Designing, conducting and funding of
  multicenter clinical trials in Greece and abroad
• 4. Expanding into Molecular Diagnostics
  Genetic Testing

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Establishing the RD BaseCollaborating with the
Greek Research Community I. Direct funding of
novel research ideas in Radiopharmacy and
Radiodiagnostics

• 1. Radiolabeled Biomolecules in Diagnosis and
  Therapy
• Tc99m labelled bombesin, minigastrin and
  neurotensin analogues
• Principal Investigators A. Varvarigou, NCSR
  Demokritos T. Maina, B. Nock, NCSR
  Demokritos
• Greek patents granted European patents
  pending
• Tc99m labelled YIGSR for radiodiagnosis
  immunotherapy
• Principal InvestigatorG. Koliakos, University
  of Thessalonica
• Greek patent granted European patent granted
  
• 2. Peptide Design and Synthesis
• Principal Investigator P. Cordopatis,
  University of Patras
• Greek patents granted European patents
  pending

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II. Participating as co-sponsor and/or end-user
in selected research programs funded by GSRT and
EU

• EKBAN 2003-2006 ?e???t? ???µ?s?µata
  ??t?µ???? (??????) ?a? ?e???????e? ??a G???d?a??
  Te?ape?a ?a? S??e?? ?????? ?p?p?d?? ??f?as?
  Te?ape?t???? ???te???? se e?t?µ??? S?st?µata
  ?a?a?????, ???F? ??µ????t??, ??st?t??t?
  Pasteur, Biomedica, 582.000 (budget of project,
  Biomedica participation 245.000 )
• ??O? 2003-2006 ???pt??? ?a? a???????s?
  ?ad??ep?s?µasµ???? ß??µ????? ??a d?????s? ?/?a?
  ?e?ape?a ?e?p?as??? d?af???? µ??f?? Biomedica,
  264.000 (granted by 50)
• ????? ??????????S S????G?S??S

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Biomedica Research Personnel

• May 2004
• BIOMEDICA Funded Research Programs
• 7 full time positions 4 PhDs
• Co-Sponsored Research Programs
• 5 full time positions 4 PhDs

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2. Organizing and Managing a
Radiopharmaceutical Production Unit

• A strategic alliance between BIOMEDICA and the
  Institute of Radioisotopes Radiodiagnostic
  Products has been approved by the Board of
  Directors of NCSR Demokritos in May 2004

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• Joint Venture
• Organization and Management of the Institutes
  unique Infrastructure
• Implementation of Good Manufacturing Practice
  (GMP) Protocols

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• Production of selected highly demanded
  radiopharmaceuticals in Greece and abroad
• Pilot production of novel products for clinical
  trials
• Providing specialized GMP lyophilization services
  to third parties
• Providing education and training

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NCSR Demokritos Infrastructure

• Class 100 lyophilization clean room
• Radiochemical Radiobiological Quality Control
  Labs
• Hot-Cells
• A joint BIOMEDICA NCSR Demokritos team will
  carry out development, production and QC of
  radiopharmaceuticals

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4. Expanding into Molecular Diagnostics
Genetic Testing

• BioGenomica S.A.
• Centre for Genetic Testing and Analyses
• A spin-off Company of NCSR Demokritos
• established in February 2004
• The companys business plan has been successfully
  incorporated in the PRAXE Phase B Program of GSRT
  with a total budget of 2 mil .

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BioGenomica SA Centre for Genetic
Testing and Analyses a spin-off company of NCSR
Demokritos

• Genetic testing for predisposition to hereditary
  diseases
• Cancer -Neurological and Psychiatric Disorders -
  Rare Diseases
• DNA sequencing tailoring specific laboratory
  needs
• Food industry Public health

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• Providing services to hospitals, clinics and
  diagnostic centres in Greece and abroad
• Participation in international genetic testing
  networks
• Providing services to the food and agricultural
  industry

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• June 2004
• total number of employees 6 (3 PhDs)
• State-of-the-art instrumentation
• Automated DNA Sequencing, dHPLC, Real-time PCR
  and DNA microarray-based technologies
• European Molecular Quality Network evaluation and
  accreditation

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BioGenomica Research

• Establishment of International Scientific
  Advisory Board
• Design of clinical research protocols jointly
  with medical centers and collaborative groups and
  networks
• Participation in large-scale genetic epidemiology
  studies
• Incubation of basic science, biochemical and
  biophysical research projects jointly with
  Universities and Research Institutes

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